MX366033B - Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol. - Google Patents
Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol.Info
- Publication number
- MX366033B MX366033B MX2017002042A MX2017002042A MX366033B MX 366033 B MX366033 B MX 366033B MX 2017002042 A MX2017002042 A MX 2017002042A MX 2017002042 A MX2017002042 A MX 2017002042A MX 366033 B MX366033 B MX 366033B
- Authority
- MX
- Mexico
- Prior art keywords
- methoxypropyl
- oxadiazol
- piperidin
- large scale
- isopropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con un proceso adecuado para su adopción en la fabricación a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil)piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1H-indazol de fórmula (I), el cual es un ligando receptor 5-HT4 selectivo dirigido al tratamiento sintomático de la enfermedad de Alzheimer y otros trastornos de la memoria y la cognición como el déficit de atención e hiperactividad, la enfermedad de Parkinson y la esquizofrenia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4009CH2014 | 2014-08-16 | ||
| PCT/IN2014/000677 WO2016027277A1 (en) | 2014-08-16 | 2014-10-23 | Process for large scale production of 1-isopropyl-3-{5- [1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}- 1h-indazole oxalate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017002042A MX2017002042A (es) | 2017-05-04 |
| MX366033B true MX366033B (es) | 2019-06-25 |
Family
ID=52339256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017002042A MX366033B (es) | 2014-08-16 | 2014-10-23 | Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10005711B2 (es) |
| EP (1) | EP3180333B1 (es) |
| JP (1) | JP6397131B2 (es) |
| KR (1) | KR101865868B1 (es) |
| CN (1) | CN106604921B (es) |
| AP (1) | AP2017009755A0 (es) |
| AU (1) | AU2014404001B2 (es) |
| BR (1) | BR112017002923B8 (es) |
| CA (1) | CA2957498C (es) |
| CY (1) | CY1123567T1 (es) |
| DK (1) | DK3180333T3 (es) |
| EA (1) | EA030947B1 (es) |
| ES (1) | ES2819286T3 (es) |
| HR (1) | HRP20201478T1 (es) |
| HU (1) | HUE052083T2 (es) |
| IL (1) | IL250469B (es) |
| LT (1) | LT3180333T (es) |
| MX (1) | MX366033B (es) |
| NZ (1) | NZ728918A (es) |
| PL (1) | PL3180333T3 (es) |
| PT (1) | PT3180333T (es) |
| RS (1) | RS60804B1 (es) |
| SG (1) | SG11201701138UA (es) |
| SI (1) | SI3180333T1 (es) |
| WO (1) | WO2016027277A1 (es) |
| ZA (1) | ZA201700937B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210386727A1 (en) * | 2018-10-18 | 2021-12-16 | Suven Life Sciences Limited | New uses of a 5-ht4 receptor agonist |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10130196A (ja) * | 1996-10-29 | 1998-05-19 | Toray Dow Corning Silicone Co Ltd | 脂肪酸クロライドの製造方法 |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7419989B2 (en) * | 2004-12-22 | 2008-09-02 | Theravance, Inc. | Indazole-carboxamide compounds |
| MX337721B (es) | 2011-09-19 | 2016-03-16 | Suven Life Sciences Ltd | Compuestos de heteroarilo como ligandos del receptor 5-ht4. |
| EP3099675B1 (en) | 2013-12-16 | 2018-02-14 | Suven Life Sciences Limited | Indazole compounds as 5-ht4 receptor agonists |
-
2014
- 2014-10-23 EP EP14825191.1A patent/EP3180333B1/en active Active
- 2014-10-23 SI SI201431655T patent/SI3180333T1/sl unknown
- 2014-10-23 DK DK14825191.1T patent/DK3180333T3/da active
- 2014-10-23 LT LTEP14825191.1T patent/LT3180333T/lt unknown
- 2014-10-23 PL PL14825191T patent/PL3180333T3/pl unknown
- 2014-10-23 ES ES14825191T patent/ES2819286T3/es active Active
- 2014-10-23 PT PT148251911T patent/PT3180333T/pt unknown
- 2014-10-23 WO PCT/IN2014/000677 patent/WO2016027277A1/en active Application Filing
- 2014-10-23 EA EA201790399A patent/EA030947B1/ru unknown
- 2014-10-23 AU AU2014404001A patent/AU2014404001B2/en active Active
- 2014-10-23 RS RS20201102A patent/RS60804B1/sr unknown
- 2014-10-23 US US15/504,224 patent/US10005711B2/en active Active
- 2014-10-23 KR KR1020177005809A patent/KR101865868B1/ko active IP Right Grant
- 2014-10-23 JP JP2017527994A patent/JP6397131B2/ja active Active
- 2014-10-23 BR BR112017002923A patent/BR112017002923B8/pt active IP Right Grant
- 2014-10-23 SG SG11201701138UA patent/SG11201701138UA/en unknown
- 2014-10-23 CN CN201480081243.0A patent/CN106604921B/zh active Active
- 2014-10-23 MX MX2017002042A patent/MX366033B/es active IP Right Grant
- 2014-10-23 AP AP2017009755A patent/AP2017009755A0/en unknown
- 2014-10-23 HU HUE14825191A patent/HUE052083T2/hu unknown
- 2014-10-23 CA CA2957498A patent/CA2957498C/en active Active
- 2014-10-23 NZ NZ728918A patent/NZ728918A/en unknown
-
2017
- 2017-02-06 IL IL250469A patent/IL250469B/en active IP Right Grant
- 2017-02-07 ZA ZA2017/00937A patent/ZA201700937B/en unknown
-
2020
- 2020-09-15 CY CY20201100871T patent/CY1123567T1/el unknown
- 2020-09-16 HR HRP20201478TT patent/HRP20201478T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2016006629A (es) | Proceso de produccion a gran escala de dimesilato de 1-[(2-bromofenil]sulfonil]-5-metoxi-3-[(4-metil-1-piperazinil)met il]-1h-indol monohidratado. | |
| NZ713762A (en) | Heteroaromatic compounds and their use as dopamine d1 ligands | |
| TN2015000018A1 (en) | 5-ht3 receptor antagonists | |
| MA40895B1 (fr) | Synthèse de copanlisib et son sel de dichlorhydrate | |
| ZA201604838B (en) | Process for the production of synthesis gas | |
| EP3421502C0 (en) | PROCESS FOR PRODUCING THERMALLY MODIFIED STARCH | |
| EA201692227A1 (ru) | Производные сложных аминоэфиров | |
| MX367267B (es) | Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina. | |
| MX2017002042A (es) | Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol. | |
| MX346252B (es) | Procedimiento para producir antagonistas de los receptores del peptido relacionado con el gen de calcitonina. | |
| TW201613869A (en) | Process for preparing 3,5-bis(haloalkyl)pyrazoles via acylation of ketimines | |
| IN2014CH00444A (es) | ||
| FR3017878B1 (fr) | Procede de production de lactones a partir d'une souche d'aureobasidium pullulans | |
| TH168905B (th) | กระบวนการสำหรับการผลิตขนาดใหญ่ของ 1-ไอโซโพรพิล-3-{5-[1-(3-เมทอก ซีโพรพิล)พิเพอริดิน-4-อิล]-[1,3,4]ออกซาไดอะโซล-2-อิล}-1h-อินดาโซลออกซาเลต | |
| FR3052791B1 (fr) | Procede de production de cellulose microfibrillee | |
| IN2014MU00171A (es) | ||
| TH168905A (th) | กระบวนการสำหรับการผลิตขนาดใหญ่ของ 1-ไอโซโพรพิล-3-{5-[1-(3-เมทอก ซีโพรพิล)พิเพอริดิน-4-อิล]-[1,3,4]ออกซาไดอะโซล-2-อิล}-1h-อินดาโซลออกซาเลต | |
| TH166885B (th) | กระบวนการสำหรับการผลิตขนาดใหญ่ของ 1-[(2-โบรโมเฟนิล)ซัลโฟนิล]-5-เมทอกซี-3-[(4-เมทิล-1-พิเพอราซินิล)เมทิล]-1h-อินโดลไดเมซิเลตโมโนไฮเดรต | |
| UA111025C2 (uk) | Стереоселективний метод синтезу фосфорильованих алкенів |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |