IN2013CH02295A - - Google Patents
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- Publication number
- IN2013CH02295A IN2013CH02295A IN2295CH2013A IN2013CH02295A IN 2013CH02295 A IN2013CH02295 A IN 2013CH02295A IN 2295CH2013 A IN2295CH2013 A IN 2295CH2013A IN 2013CH02295 A IN2013CH02295 A IN 2013CH02295A
- Authority
- IN
- India
- Prior art keywords
- extruder
- excipient
- zone
- fragments
- fragmenting
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
- B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
- B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
- B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
- B29B7/482—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
- B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
- B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
- B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
- B29B7/482—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs
- B29B7/483—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs the other mixing parts being discs perpendicular to the screw axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
- B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
- B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
- B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
- B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
- B29B7/488—Parts, e.g. casings, sealings; Accessories, e.g. flow controlling or throttling devices
- B29B7/489—Screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/405—Intermeshing co-rotating screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
- B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
- B29C48/82—Cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
- B29C48/875—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling for achieving a non-uniform temperature distribution, e.g. using barrels having both cooling and heating zones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2091/00—Use of waxes as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES14803934T ES2778040T3 (es) | 2013-05-27 | 2014-05-27 | Un extrusor y proceso de fragmentación por fusión en caliente |
IN2295CH2013 IN2013CH02295A (hu) | 2013-05-27 | 2014-05-27 | |
US14/888,916 US9956709B2 (en) | 2013-05-27 | 2014-05-27 | Hot melt fragmentation extruder and process |
CN201810660247.4A CN109080099B (zh) | 2013-05-27 | 2014-05-27 | 热熔破碎挤出机和方法 |
CN201480042104.7A CN105899195B (zh) | 2013-05-27 | 2014-05-27 | 热熔破碎挤出机和方法 |
JP2016505932A JP6077713B2 (ja) | 2013-05-27 | 2014-05-27 | ホットメルト断片化押出機およびプロセス |
HUE14803934A HUE048041T2 (hu) | 2013-05-27 | 2014-05-27 | Forró olvadék-fragmentációs extruder és eljárás |
EP14803934.0A EP3003682B1 (en) | 2013-05-27 | 2014-05-27 | A hot melt fragmentation extruder and process |
EP17203025.6A EP3308938A1 (en) | 2013-05-27 | 2014-05-27 | Hot melt fragmentation extruder and process |
PCT/IN2014/000358 WO2014192026A2 (en) | 2013-05-27 | 2014-05-27 | A hot melt fragmentation extruder and process |
US15/920,133 US10213948B2 (en) | 2013-05-27 | 2018-03-13 | Hot melt fragmentation extruder and process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2295CH2013 IN2013CH02295A (hu) | 2013-05-27 | 2014-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2013CH02295A true IN2013CH02295A (hu) | 2015-10-02 |
Family
ID=51989490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2295CH2013 IN2013CH02295A (hu) | 2013-05-27 | 2014-05-27 |
Country Status (8)
Country | Link |
---|---|
US (2) | US9956709B2 (hu) |
EP (2) | EP3308938A1 (hu) |
JP (1) | JP6077713B2 (hu) |
CN (2) | CN109080099B (hu) |
ES (1) | ES2778040T3 (hu) |
HU (1) | HUE048041T2 (hu) |
IN (1) | IN2013CH02295A (hu) |
WO (1) | WO2014192026A2 (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE048041T2 (hu) | 2013-05-27 | 2020-05-28 | Steerlife India Private Ltd | Forró olvadék-fragmentációs extruder és eljárás |
US20160244573A1 (en) * | 2015-02-20 | 2016-08-25 | Steer Engineering Private Limited | Blend having a styrene resin and polyphenylene ether |
CN105984110B (zh) * | 2015-03-23 | 2019-10-15 | 思蒂亚工程私人有限公司 | 一种用于同向旋转的双螺杆加工设备的元件 |
CN105058743B (zh) * | 2015-07-24 | 2018-06-26 | 广东轻工职业技术学院 | 头数渐变全程自洁的同向自洁双螺杆挤出机及其加工方法 |
HRP20220839T1 (hr) * | 2015-07-31 | 2022-10-14 | Steerlife India Private Limited | Postupak i uređaj za kontinuiranu granulaciju materijala u prahu |
ES2904866T3 (es) * | 2016-04-22 | 2022-04-06 | Steerlife India Private Ltd | Procesador de lóbulos fraccionarios y proceso relacionado para la granulación húmeda de material en polvo |
US11465327B1 (en) | 2016-04-22 | 2022-10-11 | Steerlife India Private Limited | Fractional lobe processor |
CN118022624A (zh) * | 2020-07-14 | 2024-05-14 | 驶帝生命科学印度私人有限公司 | 连续制粒系统和获得经调节的颗粒的方法 |
WO2022225979A1 (en) * | 2021-04-20 | 2022-10-27 | William Winchin Yen | Porous sheet product and methods for making and using the same |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8804313D0 (en) * | 1988-02-24 | 1988-03-23 | Apv Plc | Improvements in/relating to mixers |
FR2717476B1 (fr) * | 1994-03-16 | 1996-04-19 | Rhone Poulenc Chimie | Sphérules de coumarine et/ou dérivés et leur procédé d'obtention. |
DE19721467A1 (de) | 1997-05-22 | 1998-11-26 | Basf Ag | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
US6783270B1 (en) * | 2000-07-31 | 2004-08-31 | Steer Engineering (P) Limited | Fractional and higher lobed co-rotating twin-screw elements |
US7364755B2 (en) * | 2003-07-07 | 2008-04-29 | Synthon Ip Inc. | Modified calcium phosphate excipient |
MY148074A (en) * | 2005-05-10 | 2013-02-28 | Novartis Ag | Pharmaceutical compositions comprising imatinib and a release retardant |
EP1832281A1 (en) * | 2006-03-10 | 2007-09-12 | Abbott GmbH & Co. KG | Process for producing a solid dispersion of an active ingredient |
US20070259070A1 (en) * | 2006-05-03 | 2007-11-08 | Joo Song | Infra-red curing processes for confectionery coatings |
US8951570B2 (en) | 2007-04-26 | 2015-02-10 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
US20110092515A1 (en) * | 2008-07-03 | 2011-04-21 | Zhihui Qiu | Melt granulation process |
US20110063940A1 (en) * | 2009-09-14 | 2011-03-17 | Steer Engineering Private Limited | Method of extruder operation |
WO2011033522A1 (en) * | 2009-09-18 | 2011-03-24 | Steer Information Technologies Pvt. Ltd. | A method and system for configuring and visualizing an extruder |
PL2594138T3 (pl) * | 2011-11-17 | 2016-07-29 | Wrigley W M Jun Co | Wytłaczany chrupki wyrób cukierniczy |
EP2747980B1 (en) | 2012-02-28 | 2016-07-20 | Steer Engineering Private Limited | An extruder mixing element |
HUE048041T2 (hu) | 2013-05-27 | 2020-05-28 | Steerlife India Private Ltd | Forró olvadék-fragmentációs extruder és eljárás |
-
2014
- 2014-05-27 HU HUE14803934A patent/HUE048041T2/hu unknown
- 2014-05-27 EP EP17203025.6A patent/EP3308938A1/en active Pending
- 2014-05-27 EP EP14803934.0A patent/EP3003682B1/en active Active
- 2014-05-27 JP JP2016505932A patent/JP6077713B2/ja active Active
- 2014-05-27 ES ES14803934T patent/ES2778040T3/es active Active
- 2014-05-27 US US14/888,916 patent/US9956709B2/en active Active
- 2014-05-27 IN IN2295CH2013 patent/IN2013CH02295A/en unknown
- 2014-05-27 CN CN201810660247.4A patent/CN109080099B/zh active Active
- 2014-05-27 CN CN201480042104.7A patent/CN105899195B/zh not_active Expired - Fee Related
- 2014-05-27 WO PCT/IN2014/000358 patent/WO2014192026A2/en active Application Filing
-
2018
- 2018-03-13 US US15/920,133 patent/US10213948B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2778040T3 (es) | 2020-08-07 |
HUE048041T2 (hu) | 2020-05-28 |
CN109080099B (zh) | 2021-11-09 |
EP3003682B1 (en) | 2019-11-20 |
EP3003682A4 (en) | 2017-04-26 |
US20180200938A1 (en) | 2018-07-19 |
CN105899195A (zh) | 2016-08-24 |
WO2014192026A2 (en) | 2014-12-04 |
EP3003682A2 (en) | 2016-04-13 |
WO2014192026A3 (en) | 2016-05-12 |
JP6077713B2 (ja) | 2017-02-08 |
EP3308938A1 (en) | 2018-04-18 |
US10213948B2 (en) | 2019-02-26 |
US20160082640A1 (en) | 2016-03-24 |
CN109080099A (zh) | 2018-12-25 |
JP2016521155A (ja) | 2016-07-21 |
US9956709B2 (en) | 2018-05-01 |
CN105899195B (zh) | 2018-10-19 |
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