IN2012DN02466A - - Google Patents
Download PDFInfo
- Publication number
- IN2012DN02466A IN2012DN02466A IN2466DEN2012A IN2012DN02466A IN 2012DN02466 A IN2012DN02466 A IN 2012DN02466A IN 2466DEN2012 A IN2466DEN2012 A IN 2466DEN2012A IN 2012DN02466 A IN2012DN02466 A IN 2012DN02466A
- Authority
- IN
- India
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Non-Alcoholic Beverages (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24274109P | 2009-09-15 | 2009-09-15 | |
| PCT/US2009/059126 WO2011034551A2 (en) | 2009-09-15 | 2009-09-30 | Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02466A true IN2012DN02466A (es) | 2015-08-21 |
Family
ID=43242391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2466DEN2012 IN2012DN02466A (es) | 2009-09-15 | 2012-03-21 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20120178806A1 (es) |
| JP (2) | JP5663025B2 (es) |
| KR (1) | KR101710505B1 (es) |
| CN (1) | CN102612375B (es) |
| AR (1) | AR076184A1 (es) |
| AU (1) | AU2009352678B2 (es) |
| CA (1) | CA2774168C (es) |
| IN (1) | IN2012DN02466A (es) |
| MX (1) | MX2012003220A (es) |
| MY (1) | MY174082A (es) |
| RU (1) | RU2546005C2 (es) |
| WO (1) | WO2011034551A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011034551A2 (en) | 2009-09-15 | 2011-03-24 | Qlt Inc. | Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle |
| KR20180043846A (ko) * | 2010-04-19 | 2018-04-30 | 노벨리언 테라퓨틱스 인코포레이티드 | 내인성 레티노이드 결핍과 연관된 시각 장애의 치료 또는 완화를 위한 치료 요법 및 방법 |
| PL2718261T3 (pl) * | 2011-06-08 | 2016-08-31 | Nitto Denko Corp | Związki do nakierowywania dostarczania leku i podwyższające aktywność sirna |
| CA2865935C (en) * | 2012-03-01 | 2021-12-14 | Qlt Inc. | Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency |
| US12029715B2 (en) | 2015-05-08 | 2024-07-09 | University Of Debrecen | Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof |
| BR112017027415B1 (pt) | 2015-06-30 | 2022-03-08 | Unilever Ip Holdings B.V. | Composição na forma de uma emulsão óleo-em-água tendo um intervalo de ph de 3 a 5, método de preparação da mesma e uso de caramelo e um ou mais compostos fenólicos em uma composição tendo um ph no intervalo de 3 a 5 compreendendo óleo vegetal compreendendo ácidos graxos monoinsaturados ou poli-insaturados |
| CN109689033A (zh) * | 2016-04-28 | 2019-04-26 | 星火治疗有限公司 | 病毒载体编码异构水解醇的相对效力测定 |
| EP3541783B1 (en) | 2016-11-17 | 2023-09-27 | University of Debrecen | Precursor compounds for providing retinoids of the vitamin a5 pathway and uses thereof |
| JP2023529932A (ja) * | 2020-06-09 | 2023-07-12 | エルミネックス バイオサイエンシズ（スーチョウ）リミティド | レチノイド化合物の毎日の低用量投与による視覚障害の治療方法 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3196078A (en) | 1962-01-30 | 1965-07-20 | Ortho Pharma Corp | Process for combating retinits pigmentosa |
| US3517067A (en) | 1964-02-11 | 1970-06-23 | Eastman Kodak Co | Syntheses of quaternary phosphonium salts |
| DE2300107C2 (de) | 1973-01-03 | 1982-03-11 | Basf Ag, 6700 Ludwigshafen | Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen |
| CH590222A5 (es) | 1973-08-21 | 1977-07-29 | Hoffmann La Roche | |
| US4022913A (en) * | 1973-09-13 | 1977-05-10 | Hoffmann-La Roche Inc. | High potency vitamin A compositions |
| DE2456959A1 (de) | 1974-12-03 | 1976-06-16 | Basf Ag | 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen |
| US4532133A (en) * | 1983-05-24 | 1985-07-30 | Basf Wyandotte Corporation | Low temperature stable, emulsifiable vitamin A concentrates |
| CA1282326C (en) | 1984-12-14 | 1991-04-02 | Paul J. Jarosz | Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient |
| JPS61275266A (ja) | 1985-05-28 | 1986-12-05 | Taisho Pharmaceut Co Ltd | レチノイド誘導体 |
| CZ282548B6 (cs) | 1992-01-22 | 1997-08-13 | F. Hoffmann-La Roche Ag | Farmaceutický přípravek |
| US5310764A (en) | 1992-05-08 | 1994-05-10 | Steven Baranowitz | Treatment of age related macular degeneration with beta-carotene |
| JPH06340525A (ja) | 1993-06-02 | 1994-12-13 | Lion Corp | 安定な低眼刺激性ビタミンａ類可溶化点眼剤 |
| WO1995026734A1 (en) | 1994-04-04 | 1995-10-12 | Freeman William R | Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure |
| RU2106843C1 (ru) | 1994-06-29 | 1998-03-20 | Красноярская государственная медицинская академия | Способ лечения близорукости |
| JPH08198746A (ja) | 1995-01-18 | 1996-08-06 | Lion Corp | 可溶化点眼剤 |
| US5837728A (en) | 1995-01-27 | 1998-11-17 | Molecular Design International | 9-cis retinoic acid esters and amides and uses thereof |
| US5489611A (en) | 1995-02-10 | 1996-02-06 | Warner-Lambert Company | Method for lowering plasma levels of lipoprotein (a) |
| US5620970A (en) | 1995-06-05 | 1997-04-15 | Alcon Laboratories, Inc. | Topical ophthalmic carbonic anhydrase inhibitor formulations |
| AU6390096A (en) * | 1995-07-20 | 1997-02-18 | Pharmacia & Upjohn Company | Stable clear solutions of non-steroidal anti-inflammatory drugs for incorporation into gelatin capsules |
| US5716627A (en) | 1996-04-25 | 1998-02-10 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester |
| US5744148A (en) * | 1996-09-20 | 1998-04-28 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Stabilization of an unstable retinoid in oil-in-water emulsions for skin care compositions |
| EP0908179A1 (en) | 1997-08-23 | 1999-04-14 | Werner Bollag | Treatment of cell-mediated immune diseases |
| ZA989513B (en) | 1997-10-21 | 1999-04-21 | Alcon Lab Inc | Compositions containing histamine H2 agonists and methods of use in treating dry eye |
| US6391924B1 (en) | 1997-12-10 | 2002-05-21 | Hampar Karageozian | Taurine derivatives useable in the treatment of ophthalmic disorders |
| US6552009B2 (en) | 1998-07-16 | 2003-04-22 | Gentrix Llc | Compositions and methods of treating abnormal cell proliferation |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6372463B1 (en) | 1999-05-06 | 2002-04-16 | The President & Fellows Of Harvard College | Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof |
| US6300328B1 (en) | 1999-08-06 | 2001-10-09 | Alcon Universal Ltd. | Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage |
| US20020028849A1 (en) | 2000-04-18 | 2002-03-07 | Godkin James D. | Use of retinol in assisted-reproduction protocols |
| US6696069B2 (en) | 2000-06-30 | 2004-02-24 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin care cosmetic compositions containing phosphates and/or sulfates of branched alcohols and/or ethoxylates thereof |
| US20040077604A1 (en) * | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
| US20020142016A1 (en) * | 2000-12-28 | 2002-10-03 | Granger Stewart Paton | Stable skin care product containing a retinoid and a retinoid booster system in a dual compartment package |
| WO2002055540A1 (en) | 2001-01-11 | 2002-07-18 | Chebigen Inc. | New retinol derivatives, the method of preparations and the uses thereof |
| EP1381276A4 (en) | 2001-04-13 | 2005-02-02 | Univ Pennsylvania | METHOD FOR TREATMENT OR DEVELOPMENT SLUDGE DEGRADATION |
| ITMI20012366A1 (it) | 2001-11-09 | 2003-05-09 | Farmatron Ltd | Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali |
| WO2003045379A1 (en) * | 2001-11-30 | 2003-06-05 | Kinetek Pharmaceuticals, Inc. | Hydrazonopyrazole derivatives and their use as therapeutics |
| CA2474154A1 (en) | 2002-01-18 | 2003-07-24 | Tatton Technologies, Llc. | Methods for treating eye disorders |
| US20030215413A1 (en) | 2002-03-22 | 2003-11-20 | L'oreal | Compositions containing stabilized retinoid |
| US20040097587A1 (en) | 2002-03-27 | 2004-05-20 | Arbiser Jack L | Compositions and methods of treatment of ulcerating diseases, burns, and related conditions |
| WO2003082081A2 (en) | 2002-03-29 | 2003-10-09 | Maxim Pharmaceuticals, Inc. | Use of rom production and release inhibitors to treat and prevent intraocular damage |
| JP3854524B2 (ja) | 2002-04-01 | 2006-12-06 | ピアス株式会社 | 油溶性成分安定化組成物及びその組成物を配合した化粧料、並びに油溶性成分の安定化方法 |
| EP1527774A1 (en) * | 2003-11-03 | 2005-05-04 | Basilea Pharmaceutica AG | New formulation for retinoid-containing soft gelatin capsules |
| EP2324823A3 (en) | 2003-03-14 | 2011-11-16 | University of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| EP1510133A1 (en) | 2003-09-01 | 2005-03-02 | Belovo S.A., Egg Science & Technology | Balanced oil composition |
| CA2863230C (en) | 2003-09-04 | 2016-07-19 | Gregory R. Jackson | Method and apparatus for the detection of impaired dark adaptation |
| US7706863B2 (en) | 2004-01-21 | 2010-04-27 | University Of Washington | Methods for assessing a physiological state of a mammalian retina |
| KR20060135819A (ko) | 2004-02-17 | 2006-12-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 황반변성을 포함하는 안과질환의 관리 |
| JP2007529434A (ja) | 2004-03-17 | 2007-10-25 | ラース マイケル ラーセン， | 視覚サイクルの阻害による網膜症の予防 |
| LT2397133T (lt) | 2004-06-18 | 2018-01-10 | University Of Washington | Tinklainei skirti dariniai ir būdai, skirti naudoti regėjimo susirgimų gydymui |
| CA2569691C (en) | 2004-06-23 | 2010-08-17 | Sirion Therapeutics, Inc. | Methods and compositions for treating ophthalmic conditions with retinyl derivatives |
| US20060240098A1 (en) * | 2004-07-14 | 2006-10-26 | Aphios Corporation | Formulations for hyperforin-enriched hypericum fractions |
| WO2006033734A2 (en) | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| WO2006039551A2 (en) | 2004-09-30 | 2006-04-13 | The Regents Of The University Of California | Local administration of retinoids to treat deficiencies in dark adaptation |
| US20060177392A1 (en) | 2005-02-10 | 2006-08-10 | William Walden | Oil-based composition for acne |
| CA2618705C (en) * | 2005-11-07 | 2014-04-22 | Murty Pharmaceuticals, Inc. | Improved delivery of tetrahydrocannabinol |
| US8202541B2 (en) * | 2006-02-07 | 2012-06-19 | U.S. Nutraceuticals, LLC | Dietary supplement composition for blood lipid health |
| WO2008013983A2 (en) * | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Opsin stabilizing compounds and methods of use |
| EP3181132A1 (en) | 2007-01-15 | 2017-06-21 | Chongxi Yu | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
| US8877809B2 (en) | 2007-09-12 | 2014-11-04 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating macular degeneration |
| KR20160092032A (ko) | 2008-02-11 | 2016-08-03 | 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 | 연령-관련 망막 기능장애의 치료 및 예방 방법 |
| WO2011034551A2 (en) * | 2009-09-15 | 2011-03-24 | Qlt Inc. | Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle |
| KR20180043846A (ko) | 2010-04-19 | 2018-04-30 | 노벨리언 테라퓨틱스 인코포레이티드 | 내인성 레티노이드 결핍과 연관된 시각 장애의 치료 또는 완화를 위한 치료 요법 및 방법 |
-
2009
- 2009-09-30 WO PCT/US2009/059126 patent/WO2011034551A2/en not_active Ceased
- 2009-09-30 US US13/496,113 patent/US20120178806A1/en not_active Abandoned
- 2009-09-30 JP JP2012529727A patent/JP5663025B2/ja not_active Expired - Fee Related
- 2009-09-30 MX MX2012003220A patent/MX2012003220A/es active IP Right Grant
- 2009-09-30 KR KR1020127009638A patent/KR101710505B1/ko not_active Expired - Fee Related
- 2009-09-30 AU AU2009352678A patent/AU2009352678B2/en not_active Ceased
- 2009-09-30 RU RU2012114791/15A patent/RU2546005C2/ru active
- 2009-09-30 CN CN200980162279.0A patent/CN102612375B/zh not_active Expired - Fee Related
- 2009-09-30 CA CA2774168A patent/CA2774168C/en active Active
-
2010
- 2010-03-31 AR ARP100101113A patent/AR076184A1/es not_active Application Discontinuation
- 2010-09-30 MY MYPI2012001162A patent/MY174082A/en unknown
-
2012
- 2012-03-21 IN IN2466DEN2012 patent/IN2012DN02466A/en unknown
-
2014
- 2014-07-07 JP JP2014139741A patent/JP2014185185A/ja not_active Withdrawn
-
2016
- 2016-09-23 US US15/274,257 patent/US10130606B2/en active Active
-
2018
- 2018-10-12 US US16/158,738 patent/US10736865B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170007565A1 (en) | 2017-01-12 |
| AU2009352678A1 (en) | 2012-04-05 |
| US20190183835A1 (en) | 2019-06-20 |
| US10130606B2 (en) | 2018-11-20 |
| MX2012003220A (es) | 2012-08-03 |
| AR076184A1 (es) | 2011-05-26 |
| CN102612375A (zh) | 2012-07-25 |
| CA2774168C (en) | 2021-02-23 |
| HK1170158A1 (zh) | 2013-02-22 |
| MY174082A (en) | 2020-03-09 |
| JP2014185185A (ja) | 2014-10-02 |
| KR20120064707A (ko) | 2012-06-19 |
| BR112012005905A2 (pt) | 2020-02-18 |
| US10736865B2 (en) | 2020-08-11 |
| US20120178806A1 (en) | 2012-07-12 |
| CA2774168A1 (en) | 2011-03-24 |
| WO2011034551A3 (en) | 2011-12-15 |
| KR101710505B1 (ko) | 2017-02-27 |
| RU2546005C2 (ru) | 2015-04-10 |
| JP2013504617A (ja) | 2013-02-07 |
| WO2011034551A2 (en) | 2011-03-24 |
| CN102612375B (zh) | 2016-01-27 |
| JP5663025B2 (ja) | 2015-02-04 |
| RU2012114791A (ru) | 2013-10-27 |
| AU2009352678B2 (en) | 2015-05-21 |