IN2012DN01325A - - Google Patents
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- Publication number
- IN2012DN01325A IN2012DN01325A IN1325DEN2012A IN2012DN01325A IN 2012DN01325 A IN2012DN01325 A IN 2012DN01325A IN 1325DEN2012 A IN1325DEN2012 A IN 1325DEN2012A IN 2012DN01325 A IN2012DN01325 A IN 2012DN01325A
- Authority
- IN
- India
- Prior art keywords
- alkyl
- independently
- pi3k
- heteroaryl
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0914594A GB0914594D0 (en) | 2009-08-20 | 2009-08-20 | Compounds |
GBGB1005584.6A GB201005584D0 (en) | 2010-04-01 | 2010-04-01 | Compounds |
PCT/GB2010/051370 WO2011021038A1 (en) | 2009-08-20 | 2010-08-19 | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2012DN01325A true IN2012DN01325A (me) | 2015-06-05 |
Family
ID=42756474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN1325DEN2012 IN2012DN01325A (me) | 2009-08-20 | 2010-08-19 |
Country Status (15)
Country | Link |
---|---|
US (4) | US9200007B2 (me) |
EP (1) | EP2467387B1 (me) |
JP (1) | JP5746172B2 (me) |
CN (1) | CN102498115B (me) |
AU (1) | AU2010286168B2 (me) |
BR (1) | BR112012003955A2 (me) |
CA (1) | CA2771594C (me) |
ES (1) | ES2534326T3 (me) |
IL (1) | IL217903A (me) |
IN (1) | IN2012DN01325A (me) |
MX (1) | MX2012002059A (me) |
NZ (1) | NZ597983A (me) |
PL (1) | PL2467387T3 (me) |
WO (1) | WO2011021038A1 (me) |
ZA (1) | ZA201200910B (me) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2534326T3 (es) * | 2009-08-20 | 2015-04-21 | Karus Therapeutics Limited | Compuestos tricíclicos heterocíclicos como inhibidores de la fosfoinositida 3-cinasa |
AU2015268776B2 (en) * | 2010-12-16 | 2017-04-13 | Genentech, Inc. | Tricyclic PI3k inhibitor compounds and methods of use |
SG190890A1 (en) * | 2010-12-16 | 2013-07-31 | Hoffmann La Roche | Tricyclic pi3k inhibitor compounds and methods of use |
EP2790705B1 (en) | 2011-12-15 | 2017-12-06 | Novartis AG | Use of inhibitors of the activity or function of pi3k |
GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
EP2897959B1 (en) * | 2012-09-20 | 2017-12-20 | UDC Ireland Limited | Azadibenzofurans for electronic applications |
JP6329958B2 (ja) | 2012-11-07 | 2018-05-23 | カルス セラピューティクス リミテッド | 新規ヒストンデアセチラーゼインヒビターおよび治療におけるその使用 |
EA035391B1 (ru) | 2012-11-08 | 2020-06-05 | Ризен Фармасьютикалз Са | Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы |
AR095443A1 (es) * | 2013-03-15 | 2015-10-14 | Fundación Centro Nac De Investig Oncológicas Carlos Iii | Heterociclos condensados con acción sobre atr |
KR20160007577A (ko) | 2013-05-10 | 2016-01-20 | 카루스 떼라퓨틱스 리미티드 | 신규한 히스톤 디아세틸라제 억제제들 |
US9814037B2 (en) * | 2013-06-28 | 2017-11-07 | Intel Corporation | Method for efficient channel estimation and beamforming in FDD system by exploiting uplink-downlink correspondence |
CN104557955B (zh) * | 2013-10-23 | 2017-05-03 | 上海汇伦生命科技有限公司 | 作为PI3K/mTOR抑制剂的三环类化合物,其制备方法和用途 |
GB201402431D0 (en) * | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
GB201514758D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514754D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
AU2016369528B2 (en) * | 2015-12-16 | 2021-04-22 | Genentech, Inc. | Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer |
TN2018000416A1 (en) | 2016-06-22 | 2020-06-15 | Univ Vanderbilt | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
ES2892956T3 (es) | 2016-11-07 | 2022-02-07 | Univ Vanderbilt | Moduladores alostéricos positivos del receptor muscarínico de acetilcolina M4 |
US10961253B2 (en) | 2016-11-07 | 2021-03-30 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
US11008335B2 (en) | 2016-11-07 | 2021-05-18 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
CN111406058A (zh) | 2017-12-05 | 2020-07-10 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
AU2019207608B2 (en) | 2018-01-10 | 2024-03-28 | Recurium Ip Holdings, Llc | Benzamide compounds |
WO2022169882A1 (en) | 2021-02-03 | 2022-08-11 | Verge Analytics, Inc. | Methods and treatment of viral infection caused by sars-cov-2 |
CN117751127A (zh) * | 2021-08-20 | 2024-03-22 | 南京大美生物制药有限公司 | 一种五元含氮杂环并杂芳基类衍生物及其用途 |
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KR101402474B1 (ko) * | 2006-04-26 | 2014-06-19 | 제넨테크, 인크. | 포스포이노시티드 3-키나제 억제제 화합물 및 이를 포함하는 약학적 조성물 |
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EP2139332A4 (en) | 2007-03-28 | 2010-04-21 | Merck Sharp & Dohme | SUBSTITUTED PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS |
JP2010529031A (ja) | 2007-05-29 | 2010-08-26 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Pi3キナーゼ阻害剤としてのナフチリジン誘導体 |
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JP2011529932A (ja) | 2008-08-05 | 2011-12-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ナフチリジン及び医薬としてのその使用 |
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WO2011012883A1 (en) | 2009-07-29 | 2011-02-03 | Karus Therapeutics Limited | Benzo [e] [1, 3 ] oxazin-4-one derivatives as phosphoinositide 3-kinase inhibitors |
ES2534326T3 (es) | 2009-08-20 | 2015-04-21 | Karus Therapeutics Limited | Compuestos tricíclicos heterocíclicos como inhibidores de la fosfoinositida 3-cinasa |
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GB201007347D0 (en) | 2010-04-30 | 2010-06-16 | Karus Therapeutics Ltd | Compounds |
RS60190B1 (sr) | 2011-07-27 | 2020-06-30 | Astrazeneca Ab | 2-(2,4,5-supstituisani-anilino) pirimidinski derivati kao egfr modulatori korisni za lečenje raka |
WO2013017480A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
JP6430390B2 (ja) | 2012-11-20 | 2018-11-28 | ジェネンテック, インコーポレイテッド | T790mを含むegfr変異体の阻害剤としてのアミノピリミジン化合物 |
KR20160007577A (ko) | 2013-05-10 | 2016-01-20 | 카루스 떼라퓨틱스 리미티드 | 신규한 히스톤 디아세틸라제 억제제들 |
AU2014273946B2 (en) | 2013-05-30 | 2020-03-12 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
WO2014210354A1 (en) | 2013-06-28 | 2014-12-31 | Genentech, Inc. | Azaindazole compounds as inhibitors of t790m containing egfr mutants |
ES2818933T3 (es) | 2013-10-10 | 2021-04-14 | Acetylon Pharmaceuticals Inc | Inhibidores de la HDAC en combinación con los inhibidores de la pi3k, para el tratamiento del linfoma no Hodgkin |
GB201321728D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321729D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321738D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
GB201321730D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
GB201514756D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compound and method of use |
GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
-
2010
- 2010-08-19 ES ES10747483.5T patent/ES2534326T3/es active Active
- 2010-08-19 WO PCT/GB2010/051370 patent/WO2011021038A1/en active Application Filing
- 2010-08-19 JP JP2012525212A patent/JP5746172B2/ja active Active
- 2010-08-19 IN IN1325DEN2012 patent/IN2012DN01325A/en unknown
- 2010-08-19 PL PL10747483T patent/PL2467387T3/pl unknown
- 2010-08-19 AU AU2010286168A patent/AU2010286168B2/en not_active Ceased
- 2010-08-19 BR BR112012003955A patent/BR112012003955A2/pt not_active Application Discontinuation
- 2010-08-19 MX MX2012002059A patent/MX2012002059A/es active IP Right Grant
- 2010-08-19 CN CN201080036402.7A patent/CN102498115B/zh active Active
- 2010-08-19 CA CA2771594A patent/CA2771594C/en not_active Expired - Fee Related
- 2010-08-19 NZ NZ597983A patent/NZ597983A/en not_active IP Right Cessation
- 2010-08-19 EP EP10747483.5A patent/EP2467387B1/en active Active
- 2010-08-19 US US13/388,164 patent/US9200007B2/en active Active
-
2012
- 2012-02-02 IL IL217903A patent/IL217903A/en active IP Right Grant
- 2012-02-07 ZA ZA2012/00910A patent/ZA201200910B/en unknown
-
2015
- 2015-10-22 US US14/920,410 patent/US9580442B2/en active Active
-
2017
- 2017-01-19 US US15/410,114 patent/US9938290B2/en active Active
-
2018
- 2018-03-01 US US15/909,011 patent/US10501478B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2467387B1 (en) | 2015-01-07 |
IL217903A (en) | 2017-08-31 |
IL217903A0 (en) | 2012-03-29 |
JP2013502404A (ja) | 2013-01-24 |
CA2771594A1 (en) | 2011-02-24 |
CN102498115A (zh) | 2012-06-13 |
AU2010286168A1 (en) | 2012-03-08 |
JP5746172B2 (ja) | 2015-07-08 |
US10501478B2 (en) | 2019-12-10 |
ES2534326T3 (es) | 2015-04-21 |
US9200007B2 (en) | 2015-12-01 |
PL2467387T3 (pl) | 2015-08-31 |
BR112012003955A2 (pt) | 2017-09-26 |
WO2011021038A1 (en) | 2011-02-24 |
US20190040079A1 (en) | 2019-02-07 |
US20160108057A1 (en) | 2016-04-21 |
US9938290B2 (en) | 2018-04-10 |
ZA201200910B (en) | 2013-05-29 |
CN102498115B (zh) | 2016-12-07 |
US20120178737A1 (en) | 2012-07-12 |
CA2771594C (en) | 2018-05-01 |
US9580442B2 (en) | 2017-02-28 |
AU2010286168B2 (en) | 2014-05-15 |
EP2467387A1 (en) | 2012-06-27 |
NZ597983A (en) | 2014-05-30 |
MX2012002059A (es) | 2012-04-19 |
US20180009826A1 (en) | 2018-01-11 |
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