IN2012DN00866A - - Google Patents

Download PDF

Info

Publication number
IN2012DN00866A
IN2012DN00866A IN866DEN2012A IN2012DN00866A IN 2012DN00866 A IN2012DN00866 A IN 2012DN00866A IN 866DEN2012 A IN866DEN2012 A IN 866DEN2012A IN 2012DN00866 A IN2012DN00866 A IN 2012DN00866A
Authority
IN
India
Prior art keywords
nucleic acids
high quality
extractions
quality nucleic
prognosis
Prior art date
Application number
Other languages
English (en)
Inventor
Leileata M Russo
Kevin C Miranda
Johan Skog
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of IN2012DN00866A publication Critical patent/IN2012DN00866A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN866DEN2012 2009-07-16 2010-07-16 IN2012DN00866A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22610609P 2009-07-16 2009-07-16
US22602509P 2009-07-16 2009-07-16
PCT/US2010/042365 WO2011009104A1 (en) 2009-07-16 2010-07-16 Nucleic acid analysis

Publications (1)

Publication Number Publication Date
IN2012DN00866A true IN2012DN00866A (zh) 2015-07-10

Family

ID=43449850

Family Applications (1)

Application Number Title Priority Date Filing Date
IN866DEN2012 IN2012DN00866A (zh) 2009-07-16 2010-07-16

Country Status (14)

Country Link
US (3) US20110195426A1 (zh)
EP (1) EP2454588B1 (zh)
JP (3) JP5909444B2 (zh)
KR (2) KR20120037992A (zh)
CN (2) CN105779436A (zh)
AU (1) AU2010273928A1 (zh)
BR (1) BR112012001077A2 (zh)
CA (1) CA2768371A1 (zh)
DK (1) DK2454588T3 (zh)
ES (1) ES2547715T3 (zh)
HK (2) HK1173213A1 (zh)
IN (1) IN2012DN00866A (zh)
SG (2) SG177677A1 (zh)
WO (1) WO2011009104A1 (zh)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3517151B1 (en) * 2006-03-09 2021-04-21 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
WO2014057128A2 (en) 2012-10-11 2014-04-17 Vin-De-Bona Trading Company Pte Ltd Method of painting microvesicles
US11266736B2 (en) 2008-04-17 2022-03-08 Vin De Bona Trading Company Pte Ltd Method of painting micro vesicles
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
EP3461912B1 (en) 2009-09-09 2022-07-13 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
WO2011156763A1 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
WO2012064993A1 (en) * 2010-11-10 2012-05-18 Exosome Diagnosties, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
EP2670868A4 (en) * 2011-01-31 2015-05-06 Esoterix Genetic Lab Llc PROCESS FOR ENRICHING MICROPARTICLES OR NUCLEIC ACIDS BY MEANS OF BONDING MOLECULES
CA2835641C (en) 2011-05-11 2019-05-28 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
WO2012170037A1 (en) 2011-06-10 2012-12-13 Hitachi Chemical Co., Ltd. Vesicle capturing devices and methods for using same
EP3492606B1 (en) 2011-08-22 2023-10-04 Exosome Diagnostics, Inc. Urine biomarkers
US10174361B2 (en) * 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
CN104995311A (zh) 2012-08-30 2015-10-21 外来体诊断公司 用于核酸测定的对照
CA2887058C (en) 2012-10-03 2022-02-22 Exosome Diagnostics, Inc. Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions
CN104736724A (zh) * 2012-10-05 2015-06-24 日立化成株式会社 尿液外泌小体mRNA和使用其检测糖尿病型肾病的方法
US10500231B2 (en) 2013-03-13 2019-12-10 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
DE212013000295U1 (de) 2013-05-06 2016-02-02 Hitachi Chemical Co. America, Ltd. Vorrichtungen zum Einfangen von Zielmolekülen
RU2668164C2 (ru) 2013-08-06 2018-09-26 Эксосам Дайэгностикс, Инк. Когорты биомаркеров мочи, профиль экспрессии генов и способы их применения
JP6657105B2 (ja) * 2013-11-06 2020-03-04 アメリカ合衆国 発現プロファイリングによりリンパ腫のタイプをサブタイピングするための方法
US10494676B2 (en) * 2013-12-02 2019-12-03 Albert-Ludwigs-Universitaet Freiburg Process for the diagnosis of cancer by using exosomes
EP3125907A4 (en) 2014-04-01 2017-11-29 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
EP3134524A4 (en) * 2014-04-22 2017-11-29 Trovagene, Inc. Concentrating nucleic acids in urine
CN104031915A (zh) * 2014-06-17 2014-09-10 复旦大学附属肿瘤医院 用于结直肠癌预后的基因片段及其应用
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US10370719B2 (en) 2014-11-12 2019-08-06 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
WO2016172598A1 (en) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
GB2539497A (en) 2015-06-19 2016-12-21 Airbus Operations Ltd A Rotational Joint For An Aircraft Folding Wing
JP6624704B2 (ja) 2015-08-31 2019-12-25 日立化成株式会社 尿路上皮疾患の評価のための分子法
US11702702B2 (en) 2016-04-15 2023-07-18 Predicine, Inc. Systems and methods for detecting genetic alterations
WO2017197399A1 (en) * 2016-05-13 2017-11-16 Exosome Diagnostics, Inc. Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free dna from biofluids
US11174503B2 (en) 2016-09-21 2021-11-16 Predicine, Inc. Systems and methods for combined detection of genetic alterations
EP3635139A1 (en) 2017-05-17 2020-04-15 Exosome Diagnostics, Inc. Microvesicle nucleic acids and/or proteins and uses thereof as markers of renal transplant rejection
EP3652315A4 (en) 2017-07-12 2021-09-01 Exosome Diagnostics, Inc. METHOD OF ISOLATION AND ENRICHMENT OF POPULATIONS OF EXTRACELLULAR VESICULES FROM A BIOFLUID AND METHOD OF USING THEREOF
JP7069587B2 (ja) * 2017-07-31 2022-05-18 東ソー株式会社 分析機器の洗浄方法
WO2019116234A1 (en) * 2017-12-12 2019-06-20 Nestec S.A. Methods for determining microbiome ribosomal rna composition changes
JP7444386B2 (ja) * 2018-06-07 2024-03-06 株式会社Ｌｓｉメディエンス ヒト尿からのマイクロベシクルの分離方法及び分析方法
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
CN109856259A (zh) * 2018-12-29 2019-06-07 南通大学附属医院 一种血清胰腺癌外泌体特异蛋白及其再验证过程
CN111593093B (zh) * 2020-03-09 2022-03-04 中山大学 一种获取adar蛋白细胞内高效结合的底物序列的方法及底物序列和应用
AU2021281287A1 (en) 2020-05-29 2023-01-19 Exosome Diagnostics, Inc. Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection
KR20230051519A (ko) 2020-08-15 2023-04-18 리제너론 파마슈티칼스 인코포레이티드 칼시토닌 수용체 (calcr)를 인코딩하는 변이체 핵산 분자를 갖는 대상체에서 비만의 치료
WO2023288130A1 (en) 2021-07-16 2023-01-19 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes
WO2023158869A1 (en) 2022-02-18 2023-08-24 Exosome Diagnostics, Inc. Use of microvesicle signatures in the identification and treatment of renal disorders
CN114480656B (zh) * 2022-03-07 2023-12-26 温州医科大学附属眼视光医院 Slc12a3和/或slc12a9在作为葡萄膜黑色素瘤治疗和预后检测指标中的应用
WO2024054572A1 (en) 2022-09-07 2024-03-14 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5840867A (en) 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
AU645915B2 (en) 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5556773A (en) 1993-08-06 1996-09-17 Yourno; Joseph Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes
US6329179B1 (en) * 1996-03-26 2001-12-11 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
DE19782095T1 (de) 1996-11-06 2000-03-23 Sequenom Inc DNA-Diagnose auf der Basis von Massenspektrometrie
US6994960B1 (en) 1997-05-28 2006-02-07 The Walter And Eliza Hall Institute Of Medical Research Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6204375B1 (en) * 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
FR2788780B1 (fr) 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
ATE428688T1 (de) 2000-01-28 2009-05-15 Mip Technologies Ab Funktionelle monomere zur molekularen erkennung und katalyse
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US6913879B1 (en) 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6525154B1 (en) 2000-07-20 2003-02-25 The Regents Of The University Of California Molecular imprinting for the recognition of peptides in aqueous solution
JP4162494B2 (ja) * 2001-05-11 2008-10-08 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 筋緊張性ジストロフィー２型に関連するイントロン、および使用方法
US20040181049A1 (en) * 2001-06-05 2004-09-16 Orr Michael S. Rna purification methods
US6696271B2 (en) 2001-08-23 2004-02-24 The Regents Of The University Of California Frozen tissue microarray technology for analysis of RNA, DNA, and proteins
WO2003023065A1 (en) 2001-09-06 2003-03-20 Syngenta Participations Ag Dna methylation patterns
US20030162190A1 (en) 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
EP2339025B1 (en) 2002-06-26 2013-10-09 Cold Spring Harbor Laboratory Methods for determining the methylation profiles
JP2005537002A (ja) 2002-09-02 2005-12-08 パムジーン ベー．ベー． 新規な一体化したマイクロアレイ分析
US7141371B2 (en) 2002-09-06 2006-11-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for detecting and localizing DNA mutations by microarray
EP1498144A1 (en) * 2003-07-15 2005-01-19 Universite Pierre Et Marie Curie Paris Vi Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell
US7384589B2 (en) 2003-08-01 2008-06-10 Lawrence Livermore National Security, Llc Nanoscale molecularly imprinted polymers and method thereof
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
CA2609260A1 (en) * 2004-06-02 2005-12-22 Sourcepharm, Inc. Rna-containing microvesicles and methods therefor
AU2005262319A1 (en) * 2004-07-01 2006-01-19 Orthogen Ag Immunosuppressive exosomes
US20060223072A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
US20080187923A1 (en) 2005-04-15 2008-08-07 Cedars-Sinai Medical Center Flow-Cytometric Heteroduplex Analysis for Detection of Genetic Alterations
US20060281108A1 (en) * 2005-05-03 2006-12-14 Althea Technologies, Inc. Compositions and methods for the analysis of degraded nucleic acids
AU2007221154A1 (en) * 2006-02-24 2007-09-07 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
JP2008035779A (ja) * 2006-08-07 2008-02-21 Mitsubishi Rayon Co Ltd 核酸の分解度を測定する方法と核酸アレイ
US20080287669A1 (en) * 2007-05-16 2008-11-20 Braman Jeffrey C Methods and compositions for identifying compounds useful in nucleic acid purification
EP2181332B1 (en) * 2007-07-25 2013-04-10 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
EP2176665B1 (en) * 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
JP5602018B2 (ja) * 2007-09-05 2014-10-08 ローレンシャン ユニバーシティー 癌患者における化学療法に対する応答を測定するために腫瘍のｒｎａ完全性を用いる方法
AU2008298744B8 (en) * 2007-09-14 2015-01-15 The Ohio State University Research Foundation MiRNA expression in human peripheral blood microvesicles and uses thereof
CA2713909C (en) * 2008-02-01 2023-12-12 The General Hospital Corporation Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions

Also Published As

Publication number Publication date
US20170114389A1 (en) 2017-04-27
CN102498397B (zh) 2016-04-06
JP5909444B2 (ja) 2016-04-26
SG2014014617A (en) 2014-05-29
ES2547715T3 (es) 2015-10-08
US20160348095A1 (en) 2016-12-01
KR20180029105A (ko) 2018-03-19
JP2012533308A (ja) 2012-12-27
KR20120037992A (ko) 2012-04-20
HK1171083A1 (zh) 2013-03-15
SG177677A1 (en) 2012-02-28
WO2011009104A1 (en) 2011-01-20
HK1173213A1 (zh) 2013-05-10
EP2454588A1 (en) 2012-05-23
JP2017131244A (ja) 2017-08-03
JP2016116512A (ja) 2016-06-30
AU2010273928A1 (en) 2012-02-09
CN102498397A (zh) 2012-06-13
BR112012001077A2 (pt) 2020-08-11
EP2454588B1 (en) 2015-07-15
CN105779436A (zh) 2016-07-20
DK2454588T3 (en) 2015-09-28
US20110195426A1 (en) 2011-08-11
AU2010273928A2 (en) 2012-02-09
EP2454588A4 (en) 2012-12-12
CA2768371A1 (en) 2011-01-20

Similar Documents

Publication Publication Date Title
IN2012DN00866A (zh)
SG10201408300PA (en) Processing of amplified dna fragments for sequencing
WO2011064225A8 (en) Novel diagnostic method for the diagnosis of alzheimer's disease or mild cognitive impairment
MY182355A (en) Hmo synthesis
WO2016015058A3 (en) Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
WO2010065420A3 (en) Universal biological sample processing
WO2008028156A3 (en) Method for producing nucleic acid probes
CA2867508C (en) Immunofluorescence and fluorescent-based nucleic acid analysis on a single sample
MX2008010669A (es) Plantas con caracteristicas mejoradas y un metodo para prepararlas.
EP4276190A3 (en) Methods for the diagnosis of bacterial vaginosis
WO2012135815A3 (en) Methods and kits for detecting cell-free pathogen-specific nucleic acids
WO2015102919A3 (en) Modular image analysis system and method
IN2015MN00457A (zh)
WO2010072822A3 (de) Präparation und amplifikation von nukleinsäuren mittels magnetischer partikel
WO2008155661A3 (en) Methods of assessing a propensity of clinical outcome for a female mammal suffering from breast cancer
ATE461294T1 (de) Brustkrebsdiagnoseverfahren
FR2901281B1 (fr) Procede d'extraction des acides desoxyribonucleiques (adn)de microorganismes eventuellement presents dans un echantillon sanguin
EP2314680A4 (en) METHOD FOR THE AMPLIFICATION OF A TARGET NUCLEIC ACID SEQUENCE, METHOD FOR METHODIC DETECTION USING THE METHOD AND REAGENT FOR USE IN THE PROCEDURES
WO2014159901A3 (en) Methods of detecting and quantifying nucleic acids within malleable polymers
WO2012011660A3 (ko) 시료 내장 마이크로 챔버 플레이트 및 분석용 마이크로 챔버 프레이트의 제조 방법, 분석용 마이크로 챔버 플레이트 및 시료 내장 마이크로 챔버 플레이트 제조 장치 셋
WO2010030111A3 (ko) 스피루리나로부터 클로로필 ａ 및 클로린을 제조하는 방법
WO2012135468A3 (en) Genetics of gender discrimination in date palm
EP2328105A3 (en) Method for determining the presence of disease
PH12019501694A1 (en) Bead beating tube and method for extracting deoxyribonucleic acid and/or ribonucleic acid from microorganisms
WO2010144553A3 (en) Methods for diagnosing blood vessel reocclusion