IN2012DN00239A - - Google Patents

Info

Publication number
IN2012DN00239A
IN2012DN00239A IN239DEN2012A IN2012DN00239A IN 2012DN00239 A IN2012DN00239 A IN 2012DN00239A IN 239DEN2012 A IN239DEN2012 A IN 239DEN2012A IN 2012DN00239 A IN2012DN00239 A IN 2012DN00239A
Authority
IN
India
Prior art keywords
compositions
morpholin
trifluoromethoxy
pyridin
biphenyl
Prior art date
Application number
Other languages
English (en)
Inventor
Andreas Fritze
Karine Corcelle
Melinda Eniko Grubesa
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2012DN00239A publication Critical patent/IN2012DN00239A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN239DEN2012 2009-07-21 2010-07-20 IN2012DN00239A (US07094801-20060822-C00173.png)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22714109P 2009-07-21 2009-07-21
US29588410P 2010-01-18 2010-01-18
PCT/EP2010/060470 WO2011009852A2 (en) 2009-07-21 2010-07-20 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
IN2012DN00239A true IN2012DN00239A (US07094801-20060822-C00173.png) 2015-05-01

Family

ID=42633096

Family Applications (1)

Application Number Title Priority Date Filing Date
IN239DEN2012 IN2012DN00239A (US07094801-20060822-C00173.png) 2009-07-21 2010-07-20

Country Status (16)

Country Link
US (1) US8722672B2 (US07094801-20060822-C00173.png)
EP (1) EP2456422B1 (US07094801-20060822-C00173.png)
JP (2) JP6106434B2 (US07094801-20060822-C00173.png)
KR (1) KR101732751B1 (US07094801-20060822-C00173.png)
CN (2) CN103893184B (US07094801-20060822-C00173.png)
AR (1) AR077490A1 (US07094801-20060822-C00173.png)
AU (1) AU2010275240A1 (US07094801-20060822-C00173.png)
BR (1) BR112012001340B1 (US07094801-20060822-C00173.png)
CA (1) CA2768457C (US07094801-20060822-C00173.png)
ES (1) ES2576740T3 (US07094801-20060822-C00173.png)
HK (1) HK1199217A1 (US07094801-20060822-C00173.png)
IN (1) IN2012DN00239A (US07094801-20060822-C00173.png)
MX (1) MX2012000954A (US07094801-20060822-C00173.png)
RU (1) RU2589699C2 (US07094801-20060822-C00173.png)
TW (1) TW201107314A (US07094801-20060822-C00173.png)
WO (1) WO2011009852A2 (US07094801-20060822-C00173.png)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明(cyclopamine)類似物類
MX349011B (es) * 2011-06-02 2017-07-05 Novartis Ag Biomarcadores para terapia de inhibidor de hedgehog.
CO6910042A1 (es) 2011-09-28 2014-03-31 Titan Wood Ltd Paneles de fibras de densidad media
PL2958550T3 (pl) * 2013-02-25 2023-01-16 Sun Pharmaceutical Industries Limited Doustna postać użytkowa i zawiesina leku onkologicznego
US10266523B2 (en) 2015-03-30 2019-04-23 Crystal Pharmatech Co., Ltd. Crystaline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-Methyl-4′-(trifluoromethoxy) [1,1′-biphenyl]-3-Methanamide monophosphate, and process of preparation thereof
WO2016196928A1 (en) 2015-06-04 2016-12-08 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
CN105330658B (zh) * 2015-12-09 2017-09-19 苏州明锐医药科技有限公司 索尼吉布的制备方法
CN112773805B (zh) * 2019-11-11 2024-05-10 中国科学院脑科学与智能技术卓越创新中心 缺血性脑损伤的新型治疗药物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082881A (en) * 1976-12-23 1978-04-04 E. R. Squibb & Sons, Inc. Topical and other type pharmaceutical formulations containing isosorbide carrier
US5216011A (en) * 1989-09-01 1993-06-01 Bristol-Myers Squibb Co. Stable solutions of mitomycin c
IT1265001B1 (it) * 1993-12-16 1996-10-17 Zambon Spa Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico
DE4405898A1 (de) * 1994-02-18 1995-08-24 Schering Ag Transdermale therapeutische Systeme enthaltend Sexualsteroide
FR2719475B1 (fr) * 1994-05-05 1996-06-07 Oreal Composition cosmétique et/ou dermatologique à gélifiant polymérique cationique, ses utilisations notamment pour la dépigmentation de la peau.
US6765001B2 (en) * 2001-12-21 2004-07-20 Medicis Pharmaceutical Corporation Compositions and methods for enhancing corticosteroid delivery
RU2207124C1 (ru) * 2002-04-24 2003-06-27 Закрытое акционерное общество "Брынцалов-А" Крем "брамизил" противогрибкового действия
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
DE102006014454B3 (de) 2006-03-29 2007-11-08 Hoffmann, Frank Stanzvorrichtung mit Zuführeinrichtung
UA93548C2 (uk) 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
CN101820950B (zh) 2007-06-07 2015-01-21 Irm责任有限公司 作为刺猬蛋白信号通路调节剂的联苯基甲酰胺类化合物
CN101445508B (zh) * 2008-11-21 2011-08-31 南京威尔化工有限公司 异山梨醇二甲醚的合成方法

Also Published As

Publication number Publication date
US20120122866A1 (en) 2012-05-17
WO2011009852A2 (en) 2011-01-27
HK1199217A1 (en) 2015-06-26
TW201107314A (en) 2011-03-01
CA2768457A1 (en) 2011-01-27
AR077490A1 (es) 2011-08-31
ES2576740T3 (es) 2016-07-11
BR112012001340B1 (pt) 2021-08-03
RU2589699C2 (ru) 2016-07-10
BR112012001340A2 (pt) 2016-03-15
CN102481249A (zh) 2012-05-30
MX2012000954A (es) 2012-02-28
CN103893184B (zh) 2016-03-02
KR101732751B1 (ko) 2017-05-04
CN103893184A (zh) 2014-07-02
KR20120097482A (ko) 2012-09-04
US8722672B2 (en) 2014-05-13
RU2012105752A (ru) 2013-08-27
EP2456422A2 (en) 2012-05-30
WO2011009852A3 (en) 2012-01-19
JP2015199753A (ja) 2015-11-12
AU2010275240A1 (en) 2012-02-02
CA2768457C (en) 2018-01-23
EP2456422B1 (en) 2016-03-16
JP6106434B2 (ja) 2017-03-29
JP2012533598A (ja) 2012-12-27

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