IN2012DE00337A - - Google Patents

Info

Publication number
IN2012DE00337A
IN2012DE00337A IN337DE2012A IN2012DE00337A IN 2012DE00337 A IN2012DE00337 A IN 2012DE00337A IN 337DE2012 A IN337DE2012 A IN 337DE2012A IN 2012DE00337 A IN2012DE00337 A IN 2012DE00337A
Authority
IN
India
Prior art keywords
addition
hydrolysis
organic solvent
solution
required quantity
Prior art date
Application number
Other languages
English (en)
Inventor
Dhiraj Khattar
Rajesh; Khanna
Sanjay Motwani
Minakshi; Garg
Vikas Chandel
Mukti; Yadav
Kyama Vijay Kumar
Vikas; Bhandari
Original Assignee
Fresenius Kabi Oncology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Oncology Ltd filed Critical Fresenius Kabi Oncology Ltd
Priority to US14/377,047 priority Critical patent/US9872873B2/en
Priority to PCT/IB2012/051513 priority patent/WO2013117969A1/en
Priority to EP12719066.8A priority patent/EP2811984B1/en
Priority to IN337DE2012 priority patent/IN2012DE00337A/en
Publication of IN2012DE00337A publication Critical patent/IN2012DE00337A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IN337DE2012 2012-02-06 2012-03-29 IN2012DE00337A (ru)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US14/377,047 US9872873B2 (en) 2012-02-06 2012-03-29 Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis
PCT/IB2012/051513 WO2013117969A1 (en) 2012-02-06 2012-03-29 Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis
EP12719066.8A EP2811984B1 (en) 2012-02-06 2012-03-29 Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis
IN337DE2012 IN2012DE00337A (ru) 2012-02-06 2012-03-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN337DE2012 IN2012DE00337A (ru) 2012-02-06 2012-03-29

Publications (1)

Publication Number Publication Date
IN2012DE00337A true IN2012DE00337A (ru) 2015-04-10

Family

ID=46028019

Family Applications (1)

Application Number Title Priority Date Filing Date
IN337DE2012 IN2012DE00337A (ru) 2012-02-06 2012-03-29

Country Status (4)

Country Link
US (1) US9872873B2 (ru)
EP (1) EP2811984B1 (ru)
IN (1) IN2012DE00337A (ru)
WO (1) WO2013117969A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN103945902B (zh) 2011-08-30 2018-07-20 阿斯泰克斯制药公司 地西他滨衍生物制剂
US9801859B2 (en) * 2012-09-18 2017-10-31 Innopharma Licensing, Llc Bendamustine formulations
US9765108B2 (en) 2012-11-19 2017-09-19 Shilpa Medicare Limited Formulation of 5-azacytidine
CA2922099C (en) 2013-08-27 2022-11-29 Vasilios VOUDOURIS Bendamustine pharmaceutical compositions
CN103585168A (zh) * 2013-11-27 2014-02-19 哈尔滨誉衡药业股份有限公司 一种含有盐酸吉西他滨的药物组合物
CN104739778A (zh) * 2013-12-26 2015-07-01 山东新时代药业有限公司 一种注射用阿扎胞苷及其制备方法
CA2941632C (en) 2014-03-13 2023-10-24 Vasilios VOUDOURIS Bendamustine solid dispersions and continuous infusion
US20160095925A1 (en) * 2014-10-01 2016-04-07 Cadila Healthcare Limited Stable formulation of azacitidine or salts thereof and their process for preparation
AU2016287585B2 (en) * 2015-07-02 2020-12-17 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
CN105769775A (zh) * 2016-03-24 2016-07-20 浙江华海药业股份有限公司 一种注射用阿扎胞苷的制备方法
JP2020529409A (ja) 2017-08-03 2020-10-08 大塚製薬株式会社 薬物化合物およびその精製方法
CN108295034A (zh) * 2018-03-29 2018-07-20 健进制药有限公司 一种注射用阿扎胞苷冻干粉针及其制备方法
KR20190136284A (ko) * 2018-05-30 2019-12-10 주식회사 삼양바이오팜 안정한 아자시티딘-함유 약제학적 조성물의 제조방법
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684630A (en) 1983-08-24 1987-08-04 Repta Arnold J Method of parenterally delivering drugs and related compositions
SG144165A1 (en) 2003-07-25 2008-07-29 Wyeth Corp Cci-779 lyophilized formulations
US20060069060A1 (en) * 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
CN101361718B (zh) 2008-09-26 2013-08-28 深圳万乐药业有限公司 稳定的地西他滨冻干制剂的制备方法
CN101584670B (zh) * 2009-06-19 2011-04-20 江苏奥赛康药业有限公司 地西他滨冻干粉针剂
US20110042247A1 (en) 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives
WO2011014541A1 (en) 2009-07-30 2011-02-03 Eagle Pharmaceuticals, Inc. Stable formulations of azacitidine
WO2011103150A2 (en) * 2010-02-18 2011-08-25 Cephalon, Inc. Lyophilized preparations of bendamustine
WO2012103226A2 (en) * 2011-01-25 2012-08-02 Dr. Reddy's Laboratories Ltd. Bendamustine formulations

Also Published As

Publication number Publication date
US9872873B2 (en) 2018-01-23
US20140378407A1 (en) 2014-12-25
EP2811984A1 (en) 2014-12-17
EP2811984B1 (en) 2015-08-26
WO2013117969A1 (en) 2013-08-15

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