IL98031A - A method of expanding the range of host proteins or increasing the toxicity of insecticidal proteins, proteins and their preparation - Google Patents
A method of expanding the range of host proteins or increasing the toxicity of insecticidal proteins, proteins and their preparationInfo
- Publication number
- IL98031A IL98031A IL9803191A IL9803191A IL98031A IL 98031 A IL98031 A IL 98031A IL 9803191 A IL9803191 A IL 9803191A IL 9803191 A IL9803191 A IL 9803191A IL 98031 A IL98031 A IL 98031A
- Authority
- IL
- Israel
- Prior art keywords
- leu
- ser
- thr
- asn
- asp
- Prior art date
Links
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- 102000004169 proteins and genes Human genes 0.000 title claims description 171
- 230000000749 insecticidal effect Effects 0.000 title claims description 71
- 238000000034 method Methods 0.000 title claims description 57
- 231100000419 toxicity Toxicity 0.000 title claims description 29
- 230000001988 toxicity Effects 0.000 title claims description 29
- 230000001965 increasing effect Effects 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title description 6
- 108020004414 DNA Proteins 0.000 claims description 85
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- 108020001507 fusion proteins Proteins 0.000 claims description 62
- 101710141347 Major envelope glycoprotein Proteins 0.000 claims description 53
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- 239000013612 plasmid Substances 0.000 claims description 34
- 101710151559 Crystal protein Proteins 0.000 claims description 33
- 241000700605 Viruses Species 0.000 claims description 28
- 239000013604 expression vector Substances 0.000 claims description 28
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 24
- 108020001580 protein domains Proteins 0.000 claims description 23
- 231100000331 toxic Toxicity 0.000 claims description 23
- 230000002588 toxic effect Effects 0.000 claims description 23
- 241000193388 Bacillus thuringiensis Species 0.000 claims description 22
- 230000004927 fusion Effects 0.000 claims description 21
- 241000201370 Autographa californica nucleopolyhedrovirus Species 0.000 claims description 20
- 210000000981 epithelium Anatomy 0.000 claims description 20
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- 230000003612 virological effect Effects 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 14
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- 108010090054 Membrane Glycoproteins Proteins 0.000 claims description 7
- 102000012750 Membrane Glycoproteins Human genes 0.000 claims description 7
- 108010052285 Membrane Proteins Proteins 0.000 claims description 7
- 102000018697 Membrane Proteins Human genes 0.000 claims description 7
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- 230000010076 replication Effects 0.000 claims description 4
- 238000013519 translation Methods 0.000 claims description 4
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/518,575 US5143905A (en) | 1990-05-03 | 1990-05-03 | Method and means for extending the host range of insecticidal proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
IL98031A0 IL98031A0 (en) | 1992-06-21 |
IL98031A true IL98031A (en) | 1999-11-30 |
Family
ID=24064547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9803191A IL98031A (en) | 1990-05-03 | 1991-05-02 | A method of expanding the range of host proteins or increasing the toxicity of insecticidal proteins, proteins and their preparation |
Country Status (6)
Country | Link |
---|---|
US (2) | US5143905A (fr) |
CN (1) | CN1059760A (fr) |
AU (1) | AU7865591A (fr) |
IL (1) | IL98031A (fr) |
NZ (1) | NZ238016A (fr) |
WO (1) | WO1991017254A1 (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995002694A2 (fr) * | 1993-07-15 | 1995-01-26 | Mycogen Corporation | Substances et procedes de lutte contre les calliphorides nuisibles |
GB9321469D0 (en) * | 1993-10-18 | 1993-12-08 | Zeneca Ltd | Insecticidal proteins |
US5530195A (en) * | 1994-06-10 | 1996-06-25 | Ciba-Geigy Corporation | Bacillus thuringiensis gene encoding a toxin active against insects |
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- 1991-05-02 IL IL9803191A patent/IL98031A/en not_active IP Right Cessation
- 1991-05-02 WO PCT/US1991/003008 patent/WO1991017254A1/fr unknown
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US5143905A (en) | 1992-09-01 |
US5306628A (en) | 1994-04-26 |
WO1991017254A1 (fr) | 1991-11-14 |
CN1059760A (zh) | 1992-03-25 |
AU7865591A (en) | 1991-11-27 |
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