IL97826A0 - Ammonium salts of n5,-methyl-5,6,7,8-tetrahydrofolic acid,their preparation and pharmaceutical compositions containing them - Google Patents

Ammonium salts of n5,-methyl-5,6,7,8-tetrahydrofolic acid,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL97826A0
IL97826A0 IL97826A IL9782691A IL97826A0 IL 97826 A0 IL97826 A0 IL 97826A0 IL 97826 A IL97826 A IL 97826A IL 9782691 A IL9782691 A IL 9782691A IL 97826 A0 IL97826 A0 IL 97826A0
Authority
IL
Israel
Prior art keywords
ammonium salts
methyl
preparation
tetrahydrofolic acid
pharmaceutical compositions
Prior art date
Application number
IL97826A
Other languages
English (en)
Original Assignee
Sapec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapec Sa filed Critical Sapec Sa
Publication of IL97826A0 publication Critical patent/IL97826A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL97826A 1990-04-12 1991-04-11 Ammonium salts of n5,-methyl-5,6,7,8-tetrahydrofolic acid,their preparation and pharmaceutical compositions containing them IL97826A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1255/90A CH680731A5 (uk) 1990-04-12 1990-04-12

Publications (1)

Publication Number Publication Date
IL97826A0 true IL97826A0 (en) 1992-06-21

Family

ID=4206110

Family Applications (1)

Application Number Title Priority Date Filing Date
IL97826A IL97826A0 (en) 1990-04-12 1991-04-11 Ammonium salts of n5,-methyl-5,6,7,8-tetrahydrofolic acid,their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (2) US5194611A (uk)
EP (1) EP0455013B1 (uk)
JP (1) JP2525965B2 (uk)
AT (1) ATE124043T1 (uk)
AU (1) AU635831B2 (uk)
CA (1) CA2040397A1 (uk)
CH (1) CH680731A5 (uk)
DE (1) DE59105758D1 (uk)
ES (1) ES2075247T3 (uk)
FI (1) FI911763A (uk)
HU (1) HUT60741A (uk)
IE (1) IE911224A1 (uk)
IL (1) IL97826A0 (uk)
MX (1) MX25305A (uk)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE139799T1 (de) * 1989-12-11 1996-07-15 American Cyanamid Co Verfahren zur herstellung von optisch reinen diastereoisomeren von tetrahydrofolatverbindungen
CH680731A5 (uk) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (uk) * 1991-01-16 1993-02-26 Eprova Ag
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
CH684644A5 (de) * 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
US6989386B2 (en) * 2002-04-30 2006-01-24 Dana-Farber Cancer Institute Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
US20050032807A1 (en) * 2003-08-06 2005-02-10 Rosenwald Lindsay A. Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives
DE10349501A1 (de) 2003-10-23 2005-05-25 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
CH698729B1 (de) 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
PT2254890E (pt) * 2008-02-20 2015-07-31 Gnosis Spa Processo para a resolução diastereoisomérica do ácido 5- metiltetra-hidrofólico
AU2019298572B2 (en) 2018-07-06 2024-05-09 Merck Patent Gmbh Crystalline salts of 5-methyl-(6S)-tetrahydrofolic acid and amino acid ethyl esters
EP3646873A1 (en) * 2018-10-31 2020-05-06 Aprofol AG Folate salts

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
DE2063027A1 (de) * 1969-12-26 1971-07-01 Yamanouchi Pharmaceutical Co Ltd , Tokio Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
US5223500A (en) * 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (uk) * 1987-05-15 1990-03-15 Eprova Ag
EP0319598B1 (de) * 1987-12-07 1991-09-25 Holger Blum Stabilisierte wässrige Folsäurezubereitung
DE3821875C1 (uk) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (uk) * 1988-11-11 1991-03-28 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (uk) * 1990-04-12 1992-10-30 Sapec Fine Chemicals

Also Published As

Publication number Publication date
ES2075247T3 (es) 1995-10-01
FI911763A0 (fi) 1991-04-11
AU635831B2 (en) 1993-04-01
MX25305A (es) 1993-12-01
EP0455013B1 (de) 1995-06-21
US5194611A (en) 1993-03-16
HU911186D0 (en) 1991-10-28
CA2040397A1 (en) 1991-10-13
DE59105758D1 (de) 1995-07-27
JPH0725876A (ja) 1995-01-27
US5382581A (en) 1995-01-17
ATE124043T1 (de) 1995-07-15
HUT60741A (en) 1992-10-28
IE911224A1 (en) 1991-10-23
FI911763A (fi) 1991-10-13
EP0455013A1 (de) 1991-11-06
JP2525965B2 (ja) 1996-08-21
AU7429791A (en) 1991-11-14
CH680731A5 (uk) 1992-10-30

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