IL97585A - Pharmaceutical iodine compositions - Google Patents
Pharmaceutical iodine compositionsInfo
- Publication number
- IL97585A IL97585A IL9758591A IL9758591A IL97585A IL 97585 A IL97585 A IL 97585A IL 9758591 A IL9758591 A IL 9758591A IL 9758591 A IL9758591 A IL 9758591A IL 97585 A IL97585 A IL 97585A
- Authority
- IL
- Israel
- Prior art keywords
- iodine
- weight
- range
- composition according
- iodate
- Prior art date
Links
- 239000011630 iodine Substances 0.000 title claims abstract description 45
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 45
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims description 29
- -1 iodate ions Chemical class 0.000 claims abstract description 16
- 239000000126 substance Substances 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 7
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 13
- 230000000536 complexating effect Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 239000003021 water soluble solvent Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 abstract description 7
- 206010015150 Erythema Diseases 0.000 description 13
- 231100000321 erythema Toxicity 0.000 description 13
- 238000011282 treatment Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000002070 germicidal effect Effects 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- 229920000153 Povidone-iodine Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 229960001621 povidone-iodine Drugs 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940005633 iodate ion Drugs 0.000 description 2
- 229920004918 nonoxynol-9 Polymers 0.000 description 2
- 229940087419 nonoxynol-9 Drugs 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 description 2
- 239000001230 potassium iodate Substances 0.000 description 2
- 235000006666 potassium iodate Nutrition 0.000 description 2
- 229940093930 potassium iodate Drugs 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- ZAUYNCUCMJDAHW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;hydrogen peroxide;molecular iodine Chemical compound OO.II.C=CN1CCCC1=O ZAUYNCUCMJDAHW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010042618 Surgical procedure repeated Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011697 sodium iodate Substances 0.000 description 1
- 235000015281 sodium iodate Nutrition 0.000 description 1
- 229940032753 sodium iodate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909006346A GB9006346D0 (en) | 1990-03-21 | 1990-03-21 | Pharmaceutical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL97585A0 IL97585A0 (en) | 1992-06-21 |
| IL97585A true IL97585A (en) | 1995-05-26 |
Family
ID=10672991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9758591A IL97585A (en) | 1990-03-21 | 1991-03-18 | Pharmaceutical iodine compositions |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5709851A (ja) |
| EP (1) | EP0448288B1 (ja) |
| JP (1) | JP3240061B2 (ja) |
| AT (1) | ATE144709T1 (ja) |
| CA (1) | CA2038637C (ja) |
| DE (1) | DE69122901T2 (ja) |
| DK (1) | DK0448288T3 (ja) |
| ES (1) | ES2096621T3 (ja) |
| FI (1) | FI102354B (ja) |
| GB (2) | GB9006346D0 (ja) |
| GR (1) | GR3021986T3 (ja) |
| IE (1) | IE910922A1 (ja) |
| IL (1) | IL97585A (ja) |
| NO (1) | NO304410B1 (ja) |
| NZ (1) | NZ237394A (ja) |
| ZA (1) | ZA912070B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2609895A (en) * | 1995-06-09 | 1997-01-09 | Shenzhen Neptunus Group Co., Ltd. | A preparation of potassium iodate |
| US5643608A (en) * | 1996-03-01 | 1997-07-01 | West Agro, Inc. | Low pH germicidal iodine compositions having enhanced stability |
| US5897872A (en) * | 1997-11-12 | 1999-04-27 | Picciano; Dante J. | Iodine-containing nasal moisturizing saline solution |
| US6171611B1 (en) | 1997-11-12 | 2001-01-09 | Dante J. Picciano | Iodine-containing nasal moisturizing saline and mouthwash solutions |
| RU2271337C2 (ru) * | 2001-09-24 | 2006-03-10 | Париченко Александр Валентинович | Способ получения соляно-кислого раствора йодхлорида и устройство для осуществления этого способа |
| RU2210533C1 (ru) * | 2002-06-24 | 2003-08-20 | Талановский Владимир Федорович | Способ получения йодата калия (варианты) |
| US20040242449A1 (en) | 2003-06-02 | 2004-12-02 | Joshi Nayan H. | Nitric acid and chromic acid-free compositions and process for cleaning aluminum and aluminum alloy surfaces |
| US20050262811A1 (en) * | 2004-05-27 | 2005-12-01 | Mahmood Mohiuddin | Sterilization process for iodine-containing antimicrobial topical solutions |
| GB201114725D0 (en) | 2011-08-25 | 2011-10-12 | Altacor Ltd | Ophthalmic formulations |
| JP2017517484A (ja) | 2014-03-31 | 2017-06-29 | イオテック インターナショナル， インコーポレイテッド | 非錯体化ヨウ素の安定な組成物及び使用方法 |
| DE102014010694A1 (de) | 2014-07-09 | 2016-01-28 | Beuth Hochschule Für Technik Berlin | Jod enthaltende pharmazeutische Zusammensetzung mit antimikrobiellen Eigenschaften sowie Verfahren zur Herstellung |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2826532A (en) * | 1952-04-15 | 1958-03-11 | Gen Aniline & Film Corp | Process of stabilizing polyvinyl pyrrolidone-iodine compositions |
| US2754245A (en) * | 1954-09-23 | 1956-07-10 | Gen Aniline & Film Corp | Interhalogen adducts of polyvinyl pyrrolidone |
| DE2540170C3 (de) * | 1975-09-10 | 1979-01-18 | Basf Ag, 6700 Ludwigshafen | Verwendung von in organischer Lösung hergestelltem Polyvinylpyrrolidon zur Herstellung von stabilen wäßrigen PoIyvinylpyrrolidon-Jod-Lösungen |
| US4113857A (en) * | 1977-05-16 | 1978-09-12 | The Purdue Frederick Company | Process for the preparation of iodophor compounds and methods for stabilizing iodophor pharmaceutical compositions containing the same |
| US4323557A (en) * | 1979-07-31 | 1982-04-06 | Minnesota Mining & Manufacturing Company | Pressure-sensitive adhesive containing iodine |
| US4271149A (en) * | 1979-09-21 | 1981-06-02 | West Agro-Chemical, Inc. | Germicidal iodine compositions with enhanced iodine stability |
| DE2942179A1 (de) * | 1979-10-18 | 1981-05-07 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von pvp-iod |
| US4427631A (en) * | 1982-05-27 | 1984-01-24 | Euroceltique, S.A. | Povidone irradiation |
| IL70972A (en) * | 1983-03-02 | 1987-10-30 | Euro Celtique Sa | Method of producing standardized iodophor preparations and iodophor preparations produced thereby |
| US4946673A (en) * | 1984-05-31 | 1990-08-07 | Euroceltique, S.A. | Iodine-containing germicidal preparations and method of controlling germicidal activity |
| US4575491A (en) * | 1984-05-31 | 1986-03-11 | Euroceltique, S.A. | Method of controlling and determining germicidal activity |
| HU197513B (en) * | 1986-04-07 | 1989-04-28 | Biogal Gyogyszergyar | Process for producing pvp-i complex and chirurgic hand disinfectant comprising sam as active ingredient |
| DE3856447T2 (de) * | 1987-07-01 | 2001-06-28 | Novapharm Research Pty. Ltd., Rosebery | Biozide zusammensetzung |
-
1990
- 1990-03-21 GB GB909006346A patent/GB9006346D0/en active Pending
-
1991
- 1991-03-08 GB GB9104968A patent/GB2242629B/en not_active Expired - Lifetime
- 1991-03-12 NZ NZ237394A patent/NZ237394A/en unknown
- 1991-03-14 ES ES91302161T patent/ES2096621T3/es not_active Expired - Lifetime
- 1991-03-14 DE DE69122901T patent/DE69122901T2/de not_active Expired - Lifetime
- 1991-03-14 DK DK91302161.4T patent/DK0448288T3/da active
- 1991-03-14 AT AT91302161T patent/ATE144709T1/de not_active IP Right Cessation
- 1991-03-14 EP EP91302161A patent/EP0448288B1/en not_active Expired - Lifetime
- 1991-03-18 IL IL9758591A patent/IL97585A/en not_active IP Right Cessation
- 1991-03-19 CA CA002038637A patent/CA2038637C/en not_active Expired - Lifetime
- 1991-03-20 NO NO911119A patent/NO304410B1/no not_active IP Right Cessation
- 1991-03-20 JP JP05716891A patent/JP3240061B2/ja not_active Expired - Lifetime
- 1991-03-20 ZA ZA912070A patent/ZA912070B/xx unknown
- 1991-03-20 IE IE092291A patent/IE910922A1/en not_active IP Right Cessation
- 1991-03-20 FI FI911365A patent/FI102354B/fi active
-
1994
- 1994-05-16 US US08/243,534 patent/US5709851A/en not_active Expired - Lifetime
-
1996
- 1996-12-11 GR GR960403421T patent/GR3021986T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69122901T2 (de) | 1997-03-20 |
| FI102354B1 (fi) | 1998-11-30 |
| ATE144709T1 (de) | 1996-11-15 |
| FI911365A0 (fi) | 1991-03-20 |
| FI911365L (fi) | 1991-09-22 |
| CA2038637C (en) | 2002-11-12 |
| EP0448288B1 (en) | 1996-10-30 |
| GB9006346D0 (en) | 1990-05-16 |
| JP3240061B2 (ja) | 2001-12-17 |
| AU7274191A (en) | 1991-10-03 |
| NO304410B1 (no) | 1998-12-14 |
| GR3021986T3 (en) | 1997-03-31 |
| FI102354B (fi) | 1998-11-30 |
| ZA912070B (en) | 1992-01-29 |
| IL97585A0 (en) | 1992-06-21 |
| JPH04217628A (ja) | 1992-08-07 |
| NO911119D0 (no) | 1991-03-20 |
| ES2096621T3 (es) | 1997-03-16 |
| NO911119L (no) | 1991-09-23 |
| GB2242629B (en) | 1994-10-19 |
| GB9104968D0 (en) | 1991-04-24 |
| DE69122901D1 (de) | 1996-12-05 |
| DK0448288T3 (da) | 1996-11-25 |
| IE910922A1 (en) | 1991-09-25 |
| EP0448288A1 (en) | 1991-09-25 |
| NZ237394A (en) | 1992-12-23 |
| CA2038637A1 (en) | 1991-09-22 |
| GB2242629A (en) | 1991-10-09 |
| AU636721B2 (en) | 1993-05-06 |
| US5709851A (en) | 1998-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |