IL97055A0 - Pharmaceutical compositions for sensitizing tumor cells comprising quinazolinedione derivatives - Google Patents
Pharmaceutical compositions for sensitizing tumor cells comprising quinazolinedione derivativesInfo
- Publication number
- IL97055A0 IL97055A0 IL97055A IL9705591A IL97055A0 IL 97055 A0 IL97055 A0 IL 97055A0 IL 97055 A IL97055 A IL 97055A IL 9705591 A IL9705591 A IL 9705591A IL 97055 A0 IL97055 A0 IL 97055A0
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- tumor cells
- sensitizing tumor
- quinazolinedione derivatives
- quinazolinedione
- Prior art date
Links
- 230000001235 sensitizing effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000008515 quinazolinediones Chemical class 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 quinazolinedione compound Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47932090A | 1990-02-13 | 1990-02-13 | |
| US07/497,049 US5160727A (en) | 1990-02-13 | 1990-03-21 | Tumor cell sensitization method using quinazolinedione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL97055A0 true IL97055A0 (en) | 1992-03-29 |
Family
ID=27046201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL97055A IL97055A0 (en) | 1990-02-13 | 1991-01-25 | Pharmaceutical compositions for sensitizing tumor cells comprising quinazolinedione derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5160727A (de) |
| EP (1) | EP0524931B1 (de) |
| JP (1) | JPH05509290A (de) |
| KR (1) | KR927003058A (de) |
| AT (1) | ATE121622T1 (de) |
| AU (1) | AU646837B2 (de) |
| CA (1) | CA2076032A1 (de) |
| DE (1) | DE69109283T2 (de) |
| IE (1) | IE910476A1 (de) |
| IL (1) | IL97055A0 (de) |
| WO (1) | WO1991012006A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150398A (en) * | 1991-05-08 | 2000-11-21 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the treatment of cancer |
| US5491234A (en) * | 1992-03-30 | 1996-02-13 | Pfizer Inc. | Pyrimidine derivatives for enhancing antitumor activity |
| US5684169A (en) * | 1992-11-27 | 1997-11-04 | Ensuiko Sugar Refining Co., Ltd. | Cyclodextrin inclusion complex of taxol, and method for its production and its use |
| US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
| DE19512484A1 (de) * | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
| US5767113A (en) * | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| CA2546002C (en) | 2003-11-20 | 2012-09-18 | Janssen Pharmaceutica N.V. | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| BRPI0416206A (pt) | 2003-11-20 | 2006-12-26 | Janssen Pharmaceutica Nv | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose) |
| EA011552B1 (ru) | 2004-06-30 | 2009-04-28 | Янссен Фармацевтика Н.В. | Производные хиназолиндиона в качестве ингибиторов parp |
| SG154433A1 (en) | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Phthalazine derivatives as parp inhibitors |
| ATE540936T1 (de) | 2004-06-30 | 2012-01-15 | Janssen Pharmaceutica Nv | Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer |
| KR101188688B1 (ko) | 2004-06-30 | 2012-10-09 | 얀센 파마슈티카 엔.브이. | Ｐａｒｐ 저해제로서의 퀴나졸린디온 유도체 |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| CN101981013B (zh) | 2008-03-27 | 2013-05-29 | 詹森药业有限公司 | 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮 |
| ES2367760T3 (es) | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3819630A (en) * | 1972-08-21 | 1974-06-25 | R Parcell | 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production |
| DE3069468D1 (en) * | 1979-12-19 | 1984-11-22 | Nat Res Dev | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
| JPS58159480A (ja) * | 1982-03-17 | 1983-09-21 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JPS608274A (ja) * | 1983-06-27 | 1985-01-17 | Fujisawa Pharmaceut Co Ltd | 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤 |
| GB8707053D0 (en) * | 1987-03-25 | 1987-04-29 | Ici Plc | Anti-tumour agents |
-
1990
- 1990-03-21 US US07/497,049 patent/US5160727A/en not_active Expired - Fee Related
-
1991
- 1991-01-10 DE DE69109283T patent/DE69109283T2/de not_active Expired - Fee Related
- 1991-01-10 KR KR1019920701933A patent/KR927003058A/ko not_active Withdrawn
- 1991-01-10 AT AT91902395T patent/ATE121622T1/de not_active IP Right Cessation
- 1991-01-10 EP EP91902395A patent/EP0524931B1/de not_active Expired - Lifetime
- 1991-01-10 AU AU71544/91A patent/AU646837B2/en not_active Ceased
- 1991-01-10 CA CA002076032A patent/CA2076032A1/en not_active Abandoned
- 1991-01-10 JP JP3503001A patent/JPH05509290A/ja active Pending
- 1991-01-10 WO PCT/US1991/000205 patent/WO1991012006A2/en not_active Ceased
- 1991-01-25 IL IL97055A patent/IL97055A0/xx unknown
- 1991-02-12 IE IE047691A patent/IE910476A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE910476A1 (en) | 1991-08-14 |
| WO1991012006A2 (en) | 1991-08-22 |
| EP0524931B1 (de) | 1995-04-26 |
| DE69109283T2 (de) | 1995-08-24 |
| JPH05509290A (ja) | 1993-12-22 |
| KR927003058A (ko) | 1992-12-17 |
| US5160727A (en) | 1992-11-03 |
| AU646837B2 (en) | 1994-03-10 |
| ATE121622T1 (de) | 1995-05-15 |
| EP0524931A1 (de) | 1993-02-03 |
| CA2076032A1 (en) | 1991-08-14 |
| DE69109283D1 (de) | 1995-06-01 |
| AU7154491A (en) | 1991-09-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL97055A0 (en) | Pharmaceutical compositions for sensitizing tumor cells comprising quinazolinedione derivatives | |
| NO970039D0 (no) | Fremgangsmåte for inhibering av cancer matastaser ved oral administrering av opplöselig modifisert sitruspektin | |
| TR200002243T2 (tr) | Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı. | |
| RU93051543A (ru) | Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей | |
| CY1108363T1 (el) | Φαρμακευτικες συνθεσεις που περιλαμβανουν τριοξειδιο αρσενικου για την θεραπεια του μη-hodgkin λεμφωματος | |
| DK0490077T3 (da) | Antisense-oligonukleotider til behandling af cancer | |
| ZA921911B (en) | 2,4-diaminoquinazoline derivatives for enhancing anti-tumor activity. | |
| IL118426A (en) | Pharmaceutical composition containing 1,3- bis-triazolyl-2-propanol derivative for treating cancer tumors or viruses | |
| DE60039730D1 (de) | Genetisch manipulierte Herpesviren zur Behandlung von Tumoren | |
| BG104436A (en) | The administration of macrolides for the treatment of cancer and macular degeneration | |
| IL101245A0 (en) | Pharmaceutical compositions for the treatment of prostatic cancer | |
| FI960658L (fi) | Uudet bis-naftalimidit syövän hoitamiseksi | |
| HUT68876A (en) | Pharmaceutical composition for treating tumours, containing creatine phosphate or phospho-enol-pyruvic acid | |
| DE69225043D1 (de) | Injizierbares Pulver zur Behandlung von Krebs | |
| IL121440A0 (en) | The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives | |
| AU6182994A (en) | Bifunctional glycoproteins having a modified carbohydrate complement, and their use in tumor-selective therapy | |
| DK0588873T3 (da) | Behandling af levercancer | |
| TR200102576T2 (tr) | Kanser tedavisinde radyoaktif sisplatin | |
| RU97111568A (ru) | Способ лечения онкологических больных | |
| EP0938900A4 (de) | Mittel zur vorbeugung bzw. heilung der stomatitis | |
| IL106763A0 (en) | Pharmaceutical compositions for treating cancer | |
| SE8103404L (sv) | Tennforeningar, sett att framstella dem, sett att framstella ett lekemedelspreparat under anvendning av en dylik tennforening for behandling av cancer samt det pa sa sett erhallna lekemedelspreparatet | |
| CA2103708A1 (en) | Treatment of ovarian cancer | |
| EP0793499A4 (de) | Verfahren und mittel zur verminderung der tumorentwicklung mittels einer kombination aus einer taxanverbindung und einer tellur und/oder selenverbindung | |
| EP0870510A3 (de) | Synergistische Zusammensetzung enthaltend Cryptophycinderivate und synergistische mikrotubuli Mitteln |