IL95917A - Fibrinogen receptor antagonists and pharmaceutical preparations containing them - Google Patents

Fibrinogen receptor antagonists and pharmaceutical preparations containing them

Info

Publication number
IL95917A
IL95917A IL95917A IL9591790A IL95917A IL 95917 A IL95917 A IL 95917A IL 95917 A IL95917 A IL 95917A IL 9591790 A IL9591790 A IL 9591790A IL 95917 A IL95917 A IL 95917A
Authority
IL
Israel
Prior art keywords
asp
fibrinogen
gly
resin
peptide
Prior art date
Application number
IL95917A
Other languages
English (en)
Hebrew (he)
Other versions
IL95917A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23669678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL95917(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL95917A0 publication Critical patent/IL95917A0/xx
Publication of IL95917A publication Critical patent/IL95917A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60D—VEHICLE CONNECTIONS
    • B60D1/00—Traction couplings; Hitches; Draw-gear; Towing devices
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Transportation (AREA)
  • Mechanical Engineering (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL95917A 1989-10-13 1990-10-08 Fibrinogen receptor antagonists and pharmaceutical preparations containing them IL95917A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42122489A 1989-10-13 1989-10-13

Publications (2)

Publication Number Publication Date
IL95917A0 IL95917A0 (en) 1991-07-18
IL95917A true IL95917A (en) 1998-02-08

Family

ID=23669678

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95917A IL95917A (en) 1989-10-13 1990-10-08 Fibrinogen receptor antagonists and pharmaceutical preparations containing them

Country Status (16)

Country Link
EP (1) EP0422938B1 (pt)
JP (1) JP2914582B2 (pt)
KR (1) KR910007704A (pt)
AT (1) ATE118783T1 (pt)
AU (1) AU634294B2 (pt)
CA (1) CA2027315A1 (pt)
DE (1) DE69017138T2 (pt)
DK (1) DK0422938T3 (pt)
ES (1) ES2068345T3 (pt)
FI (1) FI905022A0 (pt)
IE (1) IE65197B1 (pt)
IL (1) IL95917A (pt)
NO (1) NO904431L (pt)
NZ (1) NZ235563A (pt)
PT (1) PT95582B (pt)
ZA (1) ZA908156B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795867A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5686568A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregration inhibitors
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
ATE179074T1 (de) * 1991-11-07 1999-05-15 Univ Southern California Zusammensetzungen und verfahren zur verhinderung der adhäsionbildung
AU687080B2 (en) * 1993-04-08 1998-02-19 Cis Bio International Radiolabeled compounds for thrombus imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
DE69332203T2 (de) * 1992-10-02 2003-05-28 Diatide Inc Multimerische mehrzweckwirkstoffe gegen thrombose
CA2148945A1 (en) * 1992-11-18 1994-05-26 Gregory James Wells Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
AU6697694A (en) * 1993-03-29 1994-10-24 Du Pont Merck Pharmaceutical Company, The A process and intermediate compounds useful for the preparation of platelet glycoprotein IIb/IIIa inhibitors containing N alpha--methylarginine
AU2958195A (en) * 1994-06-29 1996-01-25 Texas Biotechnology Corporation Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
GB9524630D0 (en) * 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6034057A (en) * 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
GB9613112D0 (en) 1996-06-21 1996-08-28 Zeneca Ltd Chemical compounds
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
AU736951C (en) 1998-03-19 2003-02-20 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
KR20010042704A (ko) * 1998-04-16 2001-05-25 데이비드 비. 맥윌리암스 인테그린이 인테그린 수용체에 결합하는 것을 억제하는ｎ,ｎ-이치환된 아미드
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US6435397B2 (en) 2000-04-18 2002-08-20 Progressive Tool & Industries Co. Robotic turntable
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
EP2590634B1 (en) 2010-07-09 2016-03-09 BHV Pharma, Inc. Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
US10875875B2 (en) 2017-04-26 2020-12-29 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275748B1 (fr) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés peptidiques et leur application notamment en thérapeutique
BR9008022A (pt) * 1990-05-18 1993-04-06 Hoechst Ag Amida de acido isoxazol-4-carboxilico e amidas de acido hidroxialquilideno-cianoacetico,medicamentos contendo estes compostos e sua aplicacao

Also Published As

Publication number Publication date
FI905022A0 (fi) 1990-10-12
JP2914582B2 (ja) 1999-07-05
ZA908156B (en) 1991-07-31
NZ235563A (en) 1993-04-28
NO904431D0 (no) 1990-10-12
DK0422938T3 (da) 1995-05-01
PT95582A (pt) 1991-09-13
DE69017138D1 (de) 1995-03-30
IL95917A0 (en) 1991-07-18
IE65197B1 (en) 1995-10-04
AU6457390A (en) 1991-04-18
ES2068345T3 (es) 1995-04-16
JPH03173897A (ja) 1991-07-29
EP0422938A1 (en) 1991-04-17
KR910007704A (ko) 1991-05-30
PT95582B (pt) 1999-02-26
IE903665A1 (en) 1991-04-24
ATE118783T1 (de) 1995-03-15
DE69017138T2 (de) 1995-09-28
AU634294B2 (en) 1993-02-18
CA2027315A1 (en) 1991-04-14
EP0422938B1 (en) 1995-02-22
NO904431L (no) 1991-04-15

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees