ATE118783T1 - Fibrinogen-rezeptor-antagonisten. - Google Patents

Fibrinogen-rezeptor-antagonisten.

Info

Publication number
ATE118783T1
ATE118783T1 AT90311151T AT90311151T ATE118783T1 AT E118783 T1 ATE118783 T1 AT E118783T1 AT 90311151 T AT90311151 T AT 90311151T AT 90311151 T AT90311151 T AT 90311151T AT E118783 T1 ATE118783 T1 AT E118783T1
Authority
AT
Austria
Prior art keywords
fibrinogen receptor
receptor antagonists
fibrinogen
chem
sequence
Prior art date
Application number
AT90311151T
Other languages
English (en)
Inventor
Ruth F Nutt
Stephen F Brady
Daniel F Veber
Mark E Duggan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23669678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE118783(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE118783T1 publication Critical patent/ATE118783T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60D—VEHICLE CONNECTIONS
    • B60D1/00—Traction couplings; Hitches; Draw-gear; Towing devices
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mechanical Engineering (AREA)
  • Toxicology (AREA)
  • Transportation (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT90311151T 1989-10-13 1990-10-11 Fibrinogen-rezeptor-antagonisten. ATE118783T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42122489A 1989-10-13 1989-10-13

Publications (1)

Publication Number Publication Date
ATE118783T1 true ATE118783T1 (de) 1995-03-15

Family

ID=23669678

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311151T ATE118783T1 (de) 1989-10-13 1990-10-11 Fibrinogen-rezeptor-antagonisten.

Country Status (16)

Country Link
EP (1) EP0422938B1 (de)
JP (1) JP2914582B2 (de)
KR (1) KR910007704A (de)
AT (1) ATE118783T1 (de)
AU (1) AU634294B2 (de)
CA (1) CA2027315A1 (de)
DE (1) DE69017138T2 (de)
DK (1) DK0422938T3 (de)
ES (1) ES2068345T3 (de)
FI (1) FI905022A0 (de)
IE (1) IE65197B1 (de)
IL (1) IL95917A (de)
NO (1) NO904431L (de)
NZ (1) NZ235563A (de)
PT (1) PT95582B (de)
ZA (1) ZA908156B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770564A (en) * 1989-06-16 1998-06-23 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5851839A (en) * 1989-06-16 1998-12-22 Cor Therapeutics, Inc. Platelet aggregation inhibitors
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
ES2141102T3 (es) * 1991-02-08 2000-03-16 Diatide Inc Polipeptidos marcados con tecnecio-99m para la generacion de imagenes.
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
WO1993008818A1 (en) * 1991-11-07 1993-05-13 The University Of Southern California Compositions and methods for preventing adhesion formation
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
DE69332203T2 (de) * 1992-10-02 2003-05-28 Diatide Inc Multimerische mehrzweckwirkstoffe gegen thrombose
AU5594294A (en) * 1992-11-18 1994-06-08 Du Pont Merck Pharmaceutical Company, The Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
JPH08509709A (ja) * 1993-03-29 1996-10-15 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Ｎ▲上α▼−メチルアルギニンを含有する血小板糖たんぱく▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の製造方法およびそれに用いる中間体化合物
ES2179076T3 (es) * 1993-04-08 2003-01-16 Diatide Inc Compuestos marcados radiologicamente para reproducir trombos en imagenes.
AU2958195A (en) * 1994-06-29 1996-01-25 Texas Biotechnology Corporation Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
GB9524630D0 (en) * 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
EP0842195A1 (de) * 1995-07-06 1998-05-20 Zeneca Limited Peptidinhibitoren von fibronectin
GB9613112D0 (en) 1996-06-21 1996-08-28 Zeneca Ltd Chemical compounds
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
WO1999052493A2 (en) * 1998-04-16 1999-10-21 Texas Biotechnology Corporation Compounds that inhibit the binding of integrins to their receptors
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US6435397B2 (en) 2000-04-18 2002-08-20 Progressive Tool & Industries Co. Robotic turntable
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
MY161846A (en) 2010-07-09 2017-05-15 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
US10875875B2 (en) 2017-04-26 2020-12-29 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3781263T2 (de) * 1986-12-15 1993-04-08 Inst Nat Sante Rech Med Peptid-derivate und deren verwendung in der therapie.
DK0527736T3 (da) * 1990-05-18 1997-10-20 Hoechst Ag Isoxazol-4-carboxylsyreamider og hydroxyalkyliden-cyanoacetamider, lægemidler indeholdende disse forbindelser og anvendelsen af disse lægemidler.

Also Published As

Publication number Publication date
CA2027315A1 (en) 1991-04-14
ZA908156B (en) 1991-07-31
EP0422938B1 (de) 1995-02-22
IE903665A1 (en) 1991-04-24
NO904431D0 (no) 1990-10-12
NO904431L (no) 1991-04-15
DK0422938T3 (da) 1995-05-01
PT95582B (pt) 1999-02-26
DE69017138T2 (de) 1995-09-28
AU634294B2 (en) 1993-02-18
NZ235563A (en) 1993-04-28
EP0422938A1 (de) 1991-04-17
AU6457390A (en) 1991-04-18
FI905022A0 (fi) 1990-10-12
IL95917A0 (en) 1991-07-18
ES2068345T3 (es) 1995-04-16
JPH03173897A (ja) 1991-07-29
DE69017138D1 (de) 1995-03-30
IL95917A (en) 1998-02-08
JP2914582B2 (ja) 1999-07-05
IE65197B1 (en) 1995-10-04
KR910007704A (ko) 1991-05-30
PT95582A (pt) 1991-09-13

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