IL95740A - Pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation and pharmaceutical compositions based on these compounds - Google Patents

Pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation and pharmaceutical compositions based on these compounds

Info

Publication number
IL95740A
IL95740A IL9574090A IL9574090A IL95740A IL 95740 A IL95740 A IL 95740A IL 9574090 A IL9574090 A IL 9574090A IL 9574090 A IL9574090 A IL 9574090A IL 95740 A IL95740 A IL 95740A
Authority
IL
Israel
Prior art keywords
formula
alkyl
pyrimidine
dicarboxylic acid
unsubstituted
Prior art date
Application number
IL9574090A
Other languages
English (en)
Other versions
IL95740A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL95740A0 publication Critical patent/IL95740A0/xx
Publication of IL95740A publication Critical patent/IL95740A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL9574090A 1989-09-21 1990-09-19 Pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation and pharmaceutical compositions based on these compounds IL95740A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931432A DE3931432A1 (de) 1989-09-21 1989-09-21 Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Publications (2)

Publication Number Publication Date
IL95740A0 IL95740A0 (en) 1991-06-30
IL95740A true IL95740A (en) 1994-07-31

Family

ID=6389833

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9574090A IL95740A (en) 1989-09-21 1990-09-19 Pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation and pharmaceutical compositions based on these compounds

Country Status (22)

Country Link
US (1) US5130317A (no)
EP (1) EP0418797B1 (no)
JP (1) JPH03240776A (no)
KR (1) KR910006241A (no)
AT (1) ATE110369T1 (no)
AU (2) AU635326B2 (no)
CA (1) CA2025799A1 (no)
CZ (1) CZ458390A3 (no)
DD (1) DD295835A5 (no)
DE (2) DE3931432A1 (no)
DK (1) DK0418797T3 (no)
ES (1) ES2062239T3 (no)
FI (1) FI904604A7 (no)
HU (2) HU207853B (no)
IE (1) IE903403A1 (no)
IL (1) IL95740A (no)
LV (1) LV10441A (no)
NO (1) NO904114L (no)
PL (1) PL164989B1 (no)
PT (1) PT95375A (no)
RU (1) RU1836359C (no)
ZA (1) ZA907535B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
ATE178666T1 (de) * 1992-01-13 1999-04-15 Hercules Inc Wärmeverbindbare fasern für wiederstandsfähige vliesstoffe
SG50447A1 (en) 1993-06-24 1998-07-20 Hercules Inc Skin-core high thermal bond strength fiber on melt spin system
KR100408353B1 (ko) * 1994-12-19 2004-03-09 헤르큘레스 인코포레이티드 고강도부직물용섬유의제조방법,및이로부터제조된섬유및부직물
US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
BR0207209A (pt) 2001-02-14 2004-01-27 Warner Lambert Co Inibidores de metaloproteinase de matriz de pirimidina
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
MXPA04002537A (es) 2001-10-12 2004-05-31 Warner Lambert Co Alquinos como inhibidores de metaloproteinasa de matriz.
DE10160357A1 (de) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen
US6933298B2 (en) 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases
AU2003249539A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
EP1394159A1 (fr) * 2002-08-13 2004-03-03 Warner-Lambert Company LLC Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
MXPA05001603A (es) * 2002-08-13 2005-04-25 Warner Lambert Co Derivados monociclicos como inhibidores de metaloproteinasa de matriz.
CA2497656A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
PA8578101A1 (es) * 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
AU2003301847A1 (en) * 2002-11-02 2004-06-07 Sanofi-Aventis Deutschland Gmbh Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases
DE10251019A1 (de) * 2002-11-02 2004-05-19 Aventis Pharma Deutschland Gmbh Neue Pyrimidin-4,6-dicarbonsäurediamide zur selektiven Inhibierung von Kollagenasen
US7166609B2 (en) * 2002-11-02 2007-01-23 Sanofi-Aventis Deutschland Gmbh Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
US20050004111A1 (en) * 2003-01-03 2005-01-06 Aventis Pharma Deutschland Gmbh Selective MMP-13 inhibitors
DE10300017A1 (de) * 2003-01-03 2004-07-15 Aventis Pharma Deutschland Gmbh Selektive MMP 13 Inhibitoren
WO2005016926A1 (en) * 2003-08-19 2005-02-24 Warner-Lambert Company Llc Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
JP2009522295A (ja) * 2005-12-30 2009-06-11 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド 置換ビス−アミドメタロプロテアーゼ阻害剤
EP2379525B1 (en) * 2008-12-19 2015-07-29 Boehringer Ingelheim International GmbH Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133004B (en) * 1982-11-04 1986-06-11 Ici Plc Process for the extraction of metal values and novel metal extractants
US4962109A (en) * 1985-12-23 1990-10-09 Imperial Chemical Industries Plc Insecticidally and acaricidally active pyrimidine esters and intermediates therefor
WO1988000237A1 (en) * 1986-06-27 1988-01-14 Damon Biotech, Inc. Covalent membranes
DE3703959A1 (de) * 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
AU4951690A (en) * 1988-12-30 1990-08-01 David M. Anderson Stabilized microporous materials and hydrogel materials

Also Published As

Publication number Publication date
AU633142B2 (en) 1993-01-21
IE903403A1 (en) 1991-04-10
DE3931432A1 (de) 1991-04-04
IL95740A0 (en) 1991-06-30
ZA907535B (en) 1991-06-26
DD295835A5 (de) 1991-11-14
FI904604A7 (fi) 1991-03-22
US5130317A (en) 1992-07-14
ES2062239T3 (es) 1994-12-16
KR910006241A (ko) 1991-04-27
ATE110369T1 (de) 1994-09-15
NO904114L (no) 1991-03-22
HU210822A9 (en) 1995-08-28
LV10441A (lv) 1995-02-20
PL164989B1 (en) 1994-10-31
NO904114D0 (no) 1990-09-20
RU1836359C (ru) 1993-08-23
DK0418797T3 (da) 1995-01-02
HU906007D0 (en) 1991-03-28
EP0418797A2 (de) 1991-03-27
HUT55002A (en) 1991-04-29
CZ458390A3 (en) 1995-01-18
EP0418797B1 (de) 1994-08-24
HU207853B (en) 1993-06-28
DE59006893D1 (de) 1994-09-29
AU6269890A (en) 1991-04-11
CA2025799A1 (en) 1991-03-22
PL286972A1 (en) 1991-10-21
AU635326B2 (en) 1993-03-18
FI904604A0 (fi) 1990-09-19
EP0418797A3 (en) 1991-05-08
JPH03240776A (ja) 1991-10-28
AU6269990A (en) 1991-04-11
PT95375A (pt) 1991-05-22

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