IL95638A - 5,6-dialkyl-4,5,6,7-tetrahydroimide] JK-4,5,1 [] 1,4 [- 2-converted benzodiazepines, their preparation and pharmaceutical preparations containing them and their new intermediates - Google Patents

5,6-dialkyl-4,5,6,7-tetrahydroimide] JK-4,5,1 [] 1,4 [- 2-converted benzodiazepines, their preparation and pharmaceutical preparations containing them and their new intermediates

Info

Publication number
IL95638A
IL95638A IL9563890A IL9563890A IL95638A IL 95638 A IL95638 A IL 95638A IL 9563890 A IL9563890 A IL 9563890A IL 9563890 A IL9563890 A IL 9563890A IL 95638 A IL95638 A IL 95638A
Authority
IL
Israel
Prior art keywords
formula
hydrogen
reaction
compound
aryl
Prior art date
Application number
IL9563890A
Other languages
English (en)
Hebrew (he)
Other versions
IL95638A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to IL10807490A priority Critical patent/IL108074A/en
Publication of IL95638A0 publication Critical patent/IL95638A0/xx
Priority to IL10807493A priority patent/IL108074A0/xx
Publication of IL95638A publication Critical patent/IL95638A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9563890A 1989-09-13 1990-09-11 5,6-dialkyl-4,5,6,7-tetrahydroimide] JK-4,5,1 [] 1,4 [- 2-converted benzodiazepines, their preparation and pharmaceutical preparations containing them and their new intermediates IL95638A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL10807490A IL108074A (en) 1989-09-13 1990-09-11 History 5 - Alkyl - 2, 3, 4, 5 - Tetrahydro - H1 - 1,4 [Benzodiazepine - 5 - Amine
IL10807493A IL108074A0 (en) 1989-09-13 1993-12-17 Tetrahydro (1.4) benzodiazepines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40662589A 1989-09-13 1989-09-13

Publications (2)

Publication Number Publication Date
IL95638A0 IL95638A0 (en) 1991-06-30
IL95638A true IL95638A (en) 1995-01-24

Family

ID=23608794

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10807490A IL108074A (en) 1989-09-13 1990-09-11 History 5 - Alkyl - 2, 3, 4, 5 - Tetrahydro - H1 - 1,4 [Benzodiazepine - 5 - Amine
IL9563890A IL95638A (en) 1989-09-13 1990-09-11 5,6-dialkyl-4,5,6,7-tetrahydroimide] JK-4,5,1 [] 1,4 [- 2-converted benzodiazepines, their preparation and pharmaceutical preparations containing them and their new intermediates
IL10807493A IL108074A0 (en) 1989-09-13 1993-12-17 Tetrahydro (1.4) benzodiazepines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL10807490A IL108074A (en) 1989-09-13 1990-09-11 History 5 - Alkyl - 2, 3, 4, 5 - Tetrahydro - H1 - 1,4 [Benzodiazepine - 5 - Amine

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL10807493A IL108074A0 (en) 1989-09-13 1993-12-17 Tetrahydro (1.4) benzodiazepines

Country Status (30)

Country Link
EP (2) EP0417840B1 (de)
JP (1) JPH05500053A (de)
KR (1) KR927003596A (de)
CN (1) CN1029971C (de)
AP (1) AP174A (de)
AT (1) ATE115144T1 (de)
AU (1) AU635328B2 (de)
BG (1) BG60681B1 (de)
CA (1) CA2064782A1 (de)
DE (1) DE69014784T2 (de)
DK (1) DK0417840T3 (de)
ES (1) ES2067652T3 (de)
FI (1) FI98816C (de)
GR (1) GR3015270T3 (de)
HU (1) HUT62297A (de)
IE (1) IE65357B1 (de)
IL (3) IL108074A (de)
MA (1) MA21948A1 (de)
MY (1) MY106961A (de)
NO (1) NO300328B1 (de)
NZ (1) NZ235137A (de)
OA (1) OA09565A (de)
PT (1) PT95303B (de)
RO (1) RO109199B1 (de)
RU (1) RU2099341C1 (de)
TN (1) TNSN90121A1 (de)
TW (1) TW199160B (de)
WO (1) WO1991004255A1 (de)
YU (1) YU169090A (de)
ZA (1) ZA907278B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
EP0475231A1 (de) * 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazepine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075206A (en) * 1977-02-25 1978-02-21 Eli Lilly And Company Substituted pyrroloquinoxalinones and diones
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
NO300328B1 (no) 1997-05-12
NO920505D0 (no) 1992-02-07
FI98816B (fi) 1997-05-15
AU6293490A (en) 1991-04-18
RO109199B1 (ro) 1994-12-30
PT95303A (pt) 1991-05-22
OA09565A (fr) 1993-01-31
WO1991004255A1 (en) 1991-04-04
BG96041A (bg) 1993-12-24
IL95638A0 (en) 1991-06-30
KR927003596A (ko) 1992-12-18
TNSN90121A1 (fr) 1991-03-05
JPH05500053A (ja) 1993-01-14
EP0417840B1 (de) 1994-12-07
AP9000205A0 (en) 1990-10-31
IL108074A (en) 1995-06-29
ES2067652T3 (es) 1995-04-01
CN1050192A (zh) 1991-03-27
TW199160B (de) 1993-02-01
AU635328B2 (en) 1993-03-18
ZA907278B (en) 1992-05-27
IE903313A1 (en) 1991-04-10
YU169090A (sh) 1993-10-20
BG60681B1 (bg) 1995-12-29
PT95303B (pt) 1997-06-30
EP0491751A1 (de) 1992-07-01
GR3015270T3 (en) 1995-06-30
HUT62297A (en) 1993-04-28
ATE115144T1 (de) 1994-12-15
DE69014784D1 (de) 1995-01-19
MA21948A1 (fr) 1991-04-01
MY106961A (en) 1995-08-30
CN1029971C (zh) 1995-10-11
DK0417840T3 (da) 1995-02-13
NO920505L (no) 1992-02-07
FI98816C (fi) 1997-08-25
RU2099341C1 (ru) 1997-12-20
AP174A (en) 1992-03-16
NZ235137A (en) 1992-02-25
DE69014784T2 (de) 1995-04-13
IE65357B1 (en) 1995-10-18
IL108074A0 (en) 1994-04-12
CA2064782A1 (en) 1991-03-14
EP0417840A1 (de) 1991-03-20
FI921070A0 (fi) 1992-03-12

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US6201119B1 (en) Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2(thi) ones
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Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void