IL95324A - History of G, G) 9-Diphenylalkanyl (4-methylene-2-oxo-1-oxa-8-azaspiro [4,5] decane, preparation and pharmaceutical preparations containing them - Google Patents

History of G, G) 9-Diphenylalkanyl (4-methylene-2-oxo-1-oxa-8-azaspiro [4,5] decane, preparation and pharmaceutical preparations containing them

Info

Publication number
IL95324A
IL95324A IL9532490A IL9532490A IL95324A IL 95324 A IL95324 A IL 95324A IL 9532490 A IL9532490 A IL 9532490A IL 9532490 A IL9532490 A IL 9532490A IL 95324 A IL95324 A IL 95324A
Authority
IL
Israel
Prior art keywords
formula
defined above
group
oxo
derivative
Prior art date
Application number
IL9532490A
Other languages
English (en)
Hebrew (he)
Other versions
IL95324A0 (en
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of IL95324A0 publication Critical patent/IL95324A0/xx
Publication of IL95324A publication Critical patent/IL95324A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
IL9532490A 1989-08-10 1990-08-09 History of G, G) 9-Diphenylalkanyl (4-methylene-2-oxo-1-oxa-8-azaspiro [4,5] decane, preparation and pharmaceutical preparations containing them IL95324A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU894094A HU204276B (en) 1989-08-10 1989-08-10 Process for producing new 1-oxa-2-oxo-4-methylen-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IL95324A0 IL95324A0 (en) 1991-06-30
IL95324A true IL95324A (en) 1994-02-27

Family

ID=10966866

Family Applications (2)

Application Number Title Priority Date Filing Date
IL9532490A IL95324A (en) 1989-08-10 1990-08-09 History of G, G) 9-Diphenylalkanyl (4-methylene-2-oxo-1-oxa-8-azaspiro [4,5] decane, preparation and pharmaceutical preparations containing them
IL9532590A IL95325A (en) 1989-08-10 1990-08-09 History of G, G) -8-diphenylalkenyl (-3-hydroxy-4-methyl 2-oxo-1-oxa-3,8-diazaspiro] 4,5 [decane, preparation and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL9532590A IL95325A (en) 1989-08-10 1990-08-09 History of G, G) -8-diphenylalkenyl (-3-hydroxy-4-methyl 2-oxo-1-oxa-3,8-diazaspiro] 4,5 [decane, preparation and pharmaceutical preparations containing them

Country Status (26)

Country Link
US (2) US5132309A (sh)
EP (2) EP0412821B1 (sh)
JP (2) JPH0383985A (sh)
KR (2) KR940002826B1 (sh)
CN (1) CN1025031C (sh)
AT (2) ATE104671T1 (sh)
AU (2) AU621238B2 (sh)
CA (2) CA2023018C (sh)
DD (2) DD299428A5 (sh)
DE (2) DE69008275T2 (sh)
DK (1) DK0413516T3 (sh)
ES (2) ES2052179T3 (sh)
FI (1) FI93456C (sh)
HK (1) HK118295A (sh)
HU (2) HU204276B (sh)
IE (1) IE902885A1 (sh)
IL (2) IL95324A (sh)
IN (1) IN170979B (sh)
IS (1) IS3612A7 (sh)
MY (1) MY107240A (sh)
NO (1) NO903511L (sh)
NZ (2) NZ234843A (sh)
PL (2) PL163899B1 (sh)
SG (1) SG59864G (sh)
YU (2) YU150489A (sh)
ZA (3) ZA906300B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3752062T2 (de) * 1986-12-17 1997-09-11 Glaxo Group Ltd Verwendung von heterozyklischen Derivaten zur Herstellung von Arzneimitteln
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!
US6100256A (en) * 1996-12-02 2000-08-08 Merck Sharp & Dohme Ltd. Use of NK-1 receptors antagonists for treating schizophrenic disorders
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
KR20030087248A (ko) * 2002-05-08 2003-11-14 (주)씨엔아이 온라인을 통한 상거래 기초항목의 설정기능을 갖는 상거래관리장치
US8921555B2 (en) * 2009-06-16 2014-12-30 Merck Sharp & Dohme Corp. Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones
GB201416346D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL127065C (sh) * 1964-04-22
CH601304A5 (sh) * 1974-02-12 1978-07-14 Buskine Sa
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
HU204529B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE104671T1 (de) 1994-05-15
MY107240A (en) 1995-10-31
AU6080390A (en) 1991-02-14
KR910004630A (ko) 1991-03-29
IL95325A (en) 1994-06-24
ES2052179T3 (es) 1994-07-01
DD299428A5 (de) 1992-04-16
CN1049349A (zh) 1991-02-20
ZA906304B (en) 1991-06-26
SG59864G (en) 1995-09-01
DE69008275D1 (de) 1994-05-26
EP0412821B1 (en) 1994-11-09
JPH0383985A (ja) 1991-04-09
HUT59375A (en) 1992-05-28
IE902885A1 (en) 1991-02-27
DD299431A5 (de) 1992-04-16
KR910004631A (ko) 1991-03-29
IL95324A0 (en) 1991-06-30
ES2063923T3 (es) 1995-01-16
ZA906300B (en) 1991-05-29
AU621238B2 (en) 1992-03-05
KR940002826B1 (ko) 1994-04-04
ATE113951T1 (de) 1994-11-15
CA2023018A1 (en) 1991-02-11
AU621771B2 (en) 1992-03-19
PL163899B1 (pl) 1994-05-31
DE69014008T2 (de) 1995-03-23
IN170979B (sh) 1992-06-27
US5132309A (en) 1992-07-21
ZA906299B (en) 1991-06-26
FI93456B (fi) 1994-12-30
HK118295A (en) 1995-07-28
HU206677B (en) 1992-12-28
JPH0381277A (ja) 1991-04-05
IL95325A0 (en) 1991-06-30
EP0413516A3 (en) 1991-11-27
DE69014008D1 (de) 1994-12-15
CA2023018C (en) 1995-11-28
NO903511L (no) 1991-02-11
HU204276B (en) 1991-12-30
NZ234843A (en) 1992-03-26
YU154090A (sh) 1992-12-21
NO903511D0 (no) 1990-08-09
PL286443A1 (en) 1992-01-13
FI903974A0 (fi) 1990-08-10
DK0413516T3 (da) 1994-05-24
YU150489A (sh) 1992-12-21
KR940000830B1 (ko) 1994-02-02
US5132303A (en) 1992-07-21
EP0412821A3 (en) 1991-11-27
EP0413516A2 (en) 1991-02-20
HUT55785A (en) 1991-06-28
DE69008275T2 (de) 1994-08-04
NZ234846A (en) 1992-03-26
CA2023015A1 (en) 1991-02-11
AU6080490A (en) 1991-02-14
CN1025031C (zh) 1994-06-15
PL291648A1 (en) 1992-06-01
EP0413516B1 (en) 1994-04-20
EP0412821A2 (en) 1991-02-13
HU903233D0 (en) 1990-10-28
FI93456C (fi) 1995-04-10
IS3612A7 (is) 1991-02-11
PL164662B1 (pl) 1994-09-30

Similar Documents

Publication Publication Date Title
IL95324A (en) History of G, G) 9-Diphenylalkanyl (4-methylene-2-oxo-1-oxa-8-azaspiro [4,5] decane, preparation and pharmaceutical preparations containing them
US4673680A (en) α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
EP0414422B1 (en) 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
NO177709B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive ergolin-8-karboksamider
EP0412822B1 (en) 4,4-Disubstituted piperidine derivatives, processes for their preparation and pharmaceutical compositions thereof
EP0414421B1 (en) 1-Oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
EP0412820B1 (en) 2-Oxo-1-oxa-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof
HU226059B1 (en) Novel disubstituted trans-3,4,4a,5,6,10b-hexahydro-2h-naphto[1,2-b][1,4]oxazine derivatives, process for producing them and pharmaceutical compositions containing them
US4277470A (en) Heterocyclic spiro-linked amidines, compositions and use thereof
US4318909A (en) Benzoxazocines
US5010085A (en) Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine derivatives
CA2023014A1 (en) 2-oxo-1-oxa-8-azaspiro /4,5/decane derivatives, pharmaceutical compositions containing them and process for preparing the same
NO811342L (no) Fremgangsmaate for fremstilling av pyrrolokinolinderivater

Legal Events

Date Code Title Description
RH Patent void