IL93115A - Process for the preparation of an insulin precursor - Google Patents

Process for the preparation of an insulin precursor

Info

Publication number
IL93115A
IL93115A IL9311590A IL9311590A IL93115A IL 93115 A IL93115 A IL 93115A IL 9311590 A IL9311590 A IL 9311590A IL 9311590 A IL9311590 A IL 9311590A IL 93115 A IL93115 A IL 93115A
Authority
IL
Israel
Prior art keywords
insulin
cys
redox system
acid
amino acid
Prior art date
Application number
IL9311590A
Other languages
English (en)
Other versions
IL93115A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL93115A0 publication Critical patent/IL93115A0/xx
Publication of IL93115A publication Critical patent/IL93115A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Steroid Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL9311590A 1989-01-21 1990-01-19 Process for the preparation of an insulin precursor IL93115A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3901719A DE3901719A1 (de) 1989-01-21 1989-01-21 Verfahren zur herstellung eines insulinvorlaeufers

Publications (2)

Publication Number Publication Date
IL93115A0 IL93115A0 (en) 1990-11-05
IL93115A true IL93115A (en) 1995-07-31

Family

ID=6372512

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9311590A IL93115A (en) 1989-01-21 1990-01-19 Process for the preparation of an insulin precursor

Country Status (17)

Country Link
EP (1) EP0381958B1 (es)
JP (1) JPH02233699A (es)
AT (1) ATE126808T1 (es)
AU (1) AU624894B2 (es)
CA (1) CA2008245A1 (es)
DE (2) DE3901719A1 (es)
DK (1) DK0381958T3 (es)
ES (1) ES2078249T3 (es)
FI (1) FI900296A0 (es)
GR (1) GR3017591T3 (es)
HU (1) HU208704B (es)
IE (1) IE900217L (es)
IL (1) IL93115A (es)
NO (1) NO178861C (es)
NZ (1) NZ232178A (es)
PT (1) PT92907B (es)
ZA (1) ZA90396B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
ES2119779T3 (es) * 1990-09-05 1998-10-16 Southern Cross Biotech Pty Ltd Solubilizacion de proteinas en formas activas.
ES2097426T3 (es) * 1992-12-02 1997-04-01 Hoechst Ag Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
EP0871474B2 (en) * 1994-12-29 2011-09-21 Ferring International Center S.A. Generation of human insulin
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
EP1242610A1 (en) 1999-12-22 2002-09-25 Novo Nordisk A/S Method for extractive refolding of scrambledsingle-chain polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO81951B (ro) * 1980-03-27 1984-02-28 Eli Lilly And Company Procedeu de preparare a unui precursor de insulina
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern

Also Published As

Publication number Publication date
ES2078249T3 (es) 1995-12-16
NO900278D0 (no) 1990-01-19
NO178861C (no) 1996-06-19
DE59009540D1 (de) 1995-09-28
ZA90396B (en) 1990-09-26
EP0381958A2 (de) 1990-08-16
HUT54389A (en) 1991-02-28
HU208704B (en) 1993-12-28
NZ232178A (en) 1991-10-25
AU624894B2 (en) 1992-06-25
DK0381958T3 (da) 1995-12-18
FI900296A0 (fi) 1990-01-18
NO900278L (no) 1990-07-23
NO178861B (no) 1996-03-11
JPH02233699A (ja) 1990-09-17
GR3017591T3 (en) 1995-12-31
EP0381958B1 (de) 1995-08-23
ATE126808T1 (de) 1995-09-15
AU4862190A (en) 1990-07-26
CA2008245A1 (en) 1990-07-21
IL93115A0 (en) 1990-11-05
HU900197D0 (en) 1990-03-28
PT92907B (pt) 1995-12-29
PT92907A (pt) 1990-07-31
IE900217L (en) 1990-07-21
DE3901719A1 (de) 1990-07-26
EP0381958A3 (de) 1991-07-24

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Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void