ES2078249T3 - Procedimiento para la produccion de un precursor de insulina. - Google Patents

Procedimiento para la produccion de un precursor de insulina.

Info

Publication number
ES2078249T3
ES2078249T3 ES90100889T ES90100889T ES2078249T3 ES 2078249 T3 ES2078249 T3 ES 2078249T3 ES 90100889 T ES90100889 T ES 90100889T ES 90100889 T ES90100889 T ES 90100889T ES 2078249 T3 ES2078249 T3 ES 2078249T3
Authority
ES
Spain
Prior art keywords
insulin
acid
residue
amino
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90100889T
Other languages
English (en)
Inventor
Michael Dr Dorschug
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2078249T3 publication Critical patent/ES2078249T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Steroid Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

EL INVENTO SE REFIERE A UN PROCEDIMIENTO PARA PRODUCIR UNOS PRECURSOS DE INSULINA DE FORMULA (I). DICHO PROCEDIMIENTO CONSISTE EN TRATAR UNOS PRODUCTOS DE PARTIDA CON MERCAPTANOS EN EXCESO, EN PRESENCIA DE UN SISTEMA REDOX ORGANICO O DE COMPUESTOS ORGANICOS QUE FORMA UN SISTEMA REDOX ORGANICO. ASI MISMO EL INVENTO DESCRIBE LAS PROPIEDADES DEL COMPUESTO DE FORMULA (I) PARA SUMINISTRAR INSULINA EN FORMA QUIMICA O ENZIMATICA. LOS PRODUCTOS DE PARTIDA SE CARACTERIZAN PORQUE NO PRESENTAN PUENTES DE DISULFURO ENTRE LAS POSICIONES A6 Y A11, A7 Y B7 Y A20 Y B19. EL SISTEMA REDOX ORGANICO ESTA FORMADO POR UN PAR DE COMPUESTOS ACIDO ASCORBICO/ACIDO DE HIDROASCORBICO. SIENDO A1 - A20 Y B1 - B29 SECUENCIAS DE PEPTIDOS DE LA INSULINA MUTADAS A TRAVES DE UNO O VARIOS AMINOACIDOS O NO MUTADOS; R1 H O UN RESTO AMINOACIDO O PEPTIDO SEPARABLE ENZIMATICA O QUIMICAMENTE; R2 OH O UN RESTO PEPTIDO O AMINOACIDO; X UN RESTO UNIDO A LA CADENA DE INSULINA A Y B; Y Y Z RESTOS AMINOACIDOS CODIFICABLE GENETICAMENTE.
ES90100889T 1989-01-21 1990-01-17 Procedimiento para la produccion de un precursor de insulina. Expired - Lifetime ES2078249T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3901719A DE3901719A1 (de) 1989-01-21 1989-01-21 Verfahren zur herstellung eines insulinvorlaeufers

Publications (1)

Publication Number Publication Date
ES2078249T3 true ES2078249T3 (es) 1995-12-16

Family

ID=6372512

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90100889T Expired - Lifetime ES2078249T3 (es) 1989-01-21 1990-01-17 Procedimiento para la produccion de un precursor de insulina.

Country Status (17)

Country Link
EP (1) EP0381958B1 (es)
JP (1) JPH02233699A (es)
AT (1) ATE126808T1 (es)
AU (1) AU624894B2 (es)
CA (1) CA2008245A1 (es)
DE (2) DE3901719A1 (es)
DK (1) DK0381958T3 (es)
ES (1) ES2078249T3 (es)
FI (1) FI900296A0 (es)
GR (1) GR3017591T3 (es)
HU (1) HU208704B (es)
IE (1) IE900217L (es)
IL (1) IL93115A (es)
NO (1) NO178861C (es)
NZ (1) NZ232178A (es)
PT (1) PT92907B (es)
ZA (1) ZA90396B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE69129747T2 (de) * 1990-09-05 1998-11-12 Southern Cross Biotech Pty. Ltd., Toorak, Victoria In lösung bringen von proteinen in aktiver form
DK0600372T3 (da) * 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
PT871474E (pt) * 1994-12-29 2007-02-28 Ferring Int Ct Sa Produção de insulina humana
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
AU2151401A (en) * 1999-12-22 2001-07-03 Novo Nordisk A/S Method for extractive refolding of scrambled single-chain polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU76881A (en) * 1980-03-27 1984-04-30 Lilly Co Eli Process for obtaining insulin precursors
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern

Also Published As

Publication number Publication date
AU624894B2 (en) 1992-06-25
FI900296A0 (fi) 1990-01-18
PT92907A (pt) 1990-07-31
CA2008245A1 (en) 1990-07-21
ATE126808T1 (de) 1995-09-15
PT92907B (pt) 1995-12-29
DE3901719A1 (de) 1990-07-26
IL93115A (en) 1995-07-31
AU4862190A (en) 1990-07-26
NZ232178A (en) 1991-10-25
IE900217L (en) 1990-07-21
GR3017591T3 (en) 1995-12-31
HU900197D0 (en) 1990-03-28
HUT54389A (en) 1991-02-28
NO900278L (no) 1990-07-23
NO178861C (no) 1996-06-19
IL93115A0 (en) 1990-11-05
JPH02233699A (ja) 1990-09-17
NO900278D0 (no) 1990-01-19
EP0381958A2 (de) 1990-08-16
EP0381958A3 (de) 1991-07-24
ZA90396B (en) 1990-09-26
NO178861B (no) 1996-03-11
EP0381958B1 (de) 1995-08-23
DE59009540D1 (de) 1995-09-28
HU208704B (en) 1993-12-28
DK0381958T3 (da) 1995-12-18

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