IL92178A - Process for preparing pre-insulin in streptomycetes - Google Patents

Process for preparing pre-insulin in streptomycetes

Info

Publication number
IL92178A
IL92178A IL9217889A IL9217889A IL92178A IL 92178 A IL92178 A IL 92178A IL 9217889 A IL9217889 A IL 9217889A IL 9217889 A IL9217889 A IL 9217889A IL 92178 A IL92178 A IL 92178A
Authority
IL
Israel
Prior art keywords
gene
tendamistat
lys
fusion protein
proinsulin
Prior art date
Application number
IL9217889A
Other languages
English (en)
Hebrew (he)
Other versions
IL92178A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3837273A external-priority patent/DE3837273A1/de
Priority claimed from DE19893927449 external-priority patent/DE3927449A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL92178A0 publication Critical patent/IL92178A0/xx
Publication of IL92178A publication Critical patent/IL92178A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL9217889A 1988-11-03 1989-11-01 Process for preparing pre-insulin in streptomycetes IL92178A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3837273A DE3837273A1 (de) 1987-05-05 1988-11-03 Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE19893927449 DE3927449A1 (de) 1989-08-19 1989-08-19 Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten

Publications (2)

Publication Number Publication Date
IL92178A0 IL92178A0 (en) 1990-07-26
IL92178A true IL92178A (en) 1995-11-27

Family

ID=25873834

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9217889A IL92178A (en) 1988-11-03 1989-11-01 Process for preparing pre-insulin in streptomycetes

Country Status (18)

Country Link
EP (1) EP0367163B1 (hu)
JP (1) JPH02219588A (hu)
KR (1) KR900008040A (hu)
CN (1) CN1042378A (hu)
AT (1) ATE132531T1 (hu)
AU (1) AU619054B2 (hu)
CA (1) CA2002062A1 (hu)
DE (1) DE58909556D1 (hu)
DK (1) DK546889A (hu)
ES (1) ES2081826T3 (hu)
FI (1) FI95600C (hu)
GR (1) GR3018738T3 (hu)
HU (1) HU209596B (hu)
IE (1) IE893530L (hu)
IL (1) IL92178A (hu)
NO (1) NO894363L (hu)
NZ (1) NZ231222A (hu)
PT (1) PT92177B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
DE4012818A1 (de) 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
NZ239652A (en) * 1990-09-05 1992-09-25 Hoechst Ag Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
BRPI0823004B8 (pt) 2008-08-07 2021-05-25 Biocon Ltd processo para preparação de compostos de insulina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418274A1 (de) * 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt Signalpeptid fuer die exkretion von peptiden in streptomyceten
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3707150A1 (de) * 1987-03-06 1988-09-15 Hoechst Ag Tendamistat-derivate
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten

Also Published As

Publication number Publication date
DE58909556D1 (de) 1996-02-15
JPH02219588A (ja) 1990-09-03
EP0367163A3 (de) 1991-03-06
DK546889D0 (da) 1989-11-02
IE893530L (en) 1990-05-03
EP0367163A2 (de) 1990-05-09
NO894363D0 (no) 1989-11-02
KR900008040A (ko) 1990-06-02
FI95600B (fi) 1995-11-15
IL92178A0 (en) 1990-07-26
HU209596B (en) 1994-08-29
ATE132531T1 (de) 1996-01-15
AU4395089A (en) 1990-05-10
PT92177B (pt) 1995-06-30
FI895184A0 (fi) 1989-11-01
AU619054B2 (en) 1992-01-16
NZ231222A (en) 1991-08-27
GR3018738T3 (en) 1996-04-30
HU895649D0 (en) 1990-01-28
HUT53675A (en) 1990-11-28
ES2081826T3 (es) 1996-03-16
NO894363L (no) 1990-05-04
DK546889A (da) 1990-05-04
CA2002062A1 (en) 1990-05-03
FI95600C (fi) 1996-02-26
PT92177A (pt) 1990-05-31
CN1042378A (zh) 1990-05-23
EP0367163B1 (de) 1996-01-03

Similar Documents

Publication Publication Date Title
AU623963B2 (en) New insulin derivatives, a process for the preparation thereof, the use thereof and a pharmaceutical formulation containing them
EP0542863B1 (en) Expression of recombinant polypeptides with improved purification
US5304473A (en) A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
JP3085973B2 (ja) 組換え酵母による成熟タンパク質の分泌に関するシグナルペプチドについてコードする配列として新規ｄｎａ断片の適用、発現カセット、形質転換酵母及びそれに対応するタンパク質の製造方法
DK175046B1 (da) Polypeptid, dets fremstilling og anvendelse
AU638277B2 (en) Fusion proteins, their preparation and use
US5496924A (en) Fusion protein comprising an interleukin-2 fragment ballast portion
IE860737L (en) Human insulin precursors
WO1989010937A1 (en) Insulin analogues
CA2208095C (en) Generation of human insulin
CA1339894C (en) Fusion proteins with a eukaryotic ballast portion
JPH07106157B2 (ja) ヒルジン誘導体、その取得法、組換えｄｎａ及び組換えベクター
US5334532A (en) PDGF-B fusion protein, vectors, and host cells for use in production thereof
IL92178A (en) Process for preparing pre-insulin in streptomycetes
CA1338338C (en) Process for the preparation of foreign proteins in streptomycetes
US5426036A (en) Processes for the preparation of foreign proteins in streptomycetes
JP2637392B2 (ja) 遺伝子操作による生物活性β−ＮＧＦの生産方法
VÉRTESY et al. Disulphide bridge formation of proinsulin fusion proteins during secretion in Streptomyces
DE3837273A1 (de) Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void