IL92099A - Method for determination of the type and severity of periodontal disease states - Google Patents
Method for determination of the type and severity of periodontal disease statesInfo
- Publication number
- IL92099A IL92099A IL9209989A IL9209989A IL92099A IL 92099 A IL92099 A IL 92099A IL 9209989 A IL9209989 A IL 9209989A IL 9209989 A IL9209989 A IL 9209989A IL 92099 A IL92099 A IL 92099A
- Authority
- IL
- Israel
- Prior art keywords
- ast
- crevicular fluid
- activity
- periodontal disease
- sites
- Prior art date
Links
- 208000028169 periodontal disease Diseases 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 44
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims abstract description 146
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims abstract description 146
- 239000012530 fluid Substances 0.000 claims abstract description 79
- 238000005070 sampling Methods 0.000 claims abstract description 17
- 241000124008 Mammalia Species 0.000 claims abstract description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims abstract 2
- 238000011282 treatment Methods 0.000 claims description 9
- 238000003556 assay Methods 0.000 claims description 6
- 238000007398 colorimetric assay Methods 0.000 claims description 3
- 230000002745 absorbent Effects 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 238000012206 semi-quantitative assay Methods 0.000 claims 1
- 102000003929 Transaminases Human genes 0.000 abstract 1
- 108090000340 Transaminases Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 70
- 208000007565 gingivitis Diseases 0.000 description 32
- 201000001245 periodontitis Diseases 0.000 description 32
- 239000000523 sample Substances 0.000 description 24
- 230000009266 disease activity Effects 0.000 description 21
- 230000000740 bleeding effect Effects 0.000 description 16
- 208000032843 Hemorrhage Diseases 0.000 description 15
- 201000010099 disease Diseases 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 210000003731 gingival crevicular fluid Anatomy 0.000 description 13
- 241000282472 Canis lupus familiaris Species 0.000 description 12
- 238000005259 measurement Methods 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 208000034619 Gingival inflammation Diseases 0.000 description 9
- 206010061218 Inflammation Diseases 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 230000036541 health Effects 0.000 description 9
- 230000004054 inflammatory process Effects 0.000 description 9
- 102000009133 Arylsulfatases Human genes 0.000 description 8
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 8
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 8
- 108060007951 sulfatase Proteins 0.000 description 8
- 230000002596 correlated effect Effects 0.000 description 6
- 230000003239 periodontal effect Effects 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000001186 cumulative effect Effects 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 206010065687 Bone loss Diseases 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 102000029816 Collagenase Human genes 0.000 description 2
- 108060005980 Collagenase Proteins 0.000 description 2
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- 102000035092 Neutral proteases Human genes 0.000 description 2
- 108091005507 Neutral proteases Proteins 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229960002424 collagenase Drugs 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 238000010324 immunological assay Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- 238000011833 dog model Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 238000009115 maintenance therapy Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/52—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving transaminase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/262,995 US5047328A (en) | 1988-10-26 | 1988-10-26 | Method for determination of the type and severity of periodontal disease states |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL92099A0 IL92099A0 (en) | 1990-07-12 |
| IL92099A true IL92099A (en) | 1994-02-27 |
Family
ID=22999942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9209989A IL92099A (en) | 1988-10-26 | 1989-10-23 | Method for determination of the type and severity of periodontal disease states |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5047328A (de) |
| EP (1) | EP0404887B1 (de) |
| JP (1) | JPH074273B2 (de) |
| AT (1) | ATE105936T1 (de) |
| AU (1) | AU626346B2 (de) |
| CA (1) | CA2001434C (de) |
| DE (1) | DE68915437T2 (de) |
| DK (1) | DK152890A (de) |
| HK (1) | HK115694A (de) |
| IL (1) | IL92099A (de) |
| NZ (1) | NZ231133A (de) |
| WO (1) | WO1990004787A1 (de) |
| ZA (1) | ZA898122B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834226A (en) * | 1991-01-31 | 1998-11-10 | Xytronyx, Inc. | One-step test for aspartate aminotransferase |
| US5366870A (en) * | 1993-04-02 | 1994-11-22 | Xytronyx, Inc. | Limited enzyme assay for aminotransferases |
| JP2930427B2 (ja) * | 1995-04-12 | 1999-08-03 | オイ メディックス バイオケミカ エービー | 歯周疾患を判断するためのおよびその疾患が進行する危険を予報するための方法とその試験キット |
| US6063588A (en) | 1996-11-14 | 2000-05-16 | The Trustees Of Columbia University In The City Of New York | Method of diagnosing periodontal disease |
| ES2188384B1 (es) * | 2001-06-21 | 2005-01-01 | Clinica Perio, S.L. | Procedimiento de obtencion de adn humano a partir de fluido crevicular gingival. |
| JP2004129584A (ja) * | 2002-10-11 | 2004-04-30 | Applied Cell Biotechnologies Inc | 歯周病の検査方法及び検査診断薬 |
| JP2008511079A (ja) * | 2004-08-24 | 2008-04-10 | シーレーテ エルエルシー | 免疫系増強に関連したシステム及び方法 |
| JP6480278B2 (ja) * | 2015-07-08 | 2019-03-06 | 長田産業株式会社 | 歯肉炎・歯周炎の簡易判定補助方法 |
| EP3441764B1 (de) * | 2016-04-05 | 2021-01-27 | ARKRAY, Inc. | Verfahren zur bestimmung des stadiums einer parodontalerkrankung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5722698A (en) * | 1980-07-18 | 1982-02-05 | Kokusai Shiyaku Kk | Determination of got activity |
| JPS6024181A (ja) * | 1983-07-15 | 1985-02-06 | Unitika Ltd | ハイブリド−マ細胞株 |
| IL74191A0 (en) * | 1984-01-31 | 1985-04-30 | Univ Illinois | Method and kit for determining periodontal disease |
| JPS60169766A (ja) * | 1984-02-14 | 1985-09-03 | Sugiura Shinyaku Kaihatsu Kenkyusho:Kk | 可溶性画分アスパラギン酸アミノトランスフエラ−ゼ及びミトコンドリア画分アスパラギン酸アミノトランスフエラ−ゼの分別測定用試薬 |
| US4675366A (en) * | 1985-07-12 | 1987-06-23 | General Electric Company | Alkyl-containing monomers in cross-linkable polyimide compositions |
| US4801535A (en) * | 1986-03-18 | 1989-01-31 | Xytronyx, Inc. | Method for detection of periodontal disease |
-
1988
- 1988-10-26 US US07/262,995 patent/US5047328A/en not_active Expired - Lifetime
-
1989
- 1989-10-23 IL IL9209989A patent/IL92099A/en not_active IP Right Cessation
- 1989-10-25 NZ NZ231133A patent/NZ231133A/xx unknown
- 1989-10-25 JP JP1511789A patent/JPH074273B2/ja not_active Expired - Lifetime
- 1989-10-25 EP EP89912553A patent/EP0404887B1/de not_active Expired - Lifetime
- 1989-10-25 CA CA002001434A patent/CA2001434C/en not_active Expired - Fee Related
- 1989-10-25 WO PCT/US1989/004751 patent/WO1990004787A1/en not_active Ceased
- 1989-10-25 AU AU45174/89A patent/AU626346B2/en not_active Ceased
- 1989-10-25 AT AT89912553T patent/ATE105936T1/de not_active IP Right Cessation
- 1989-10-25 DE DE68915437T patent/DE68915437T2/de not_active Expired - Lifetime
- 1989-10-26 ZA ZA898122A patent/ZA898122B/xx unknown
-
1990
- 1990-06-22 DK DK152890A patent/DK152890A/da not_active Application Discontinuation
-
1994
- 1994-10-20 HK HK115694A patent/HK115694A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03502890A (ja) | 1991-07-04 |
| EP0404887A1 (de) | 1991-01-02 |
| DE68915437D1 (de) | 1994-06-23 |
| US5047328A (en) | 1991-09-10 |
| DK152890D0 (da) | 1990-06-22 |
| ZA898122B (en) | 1990-08-29 |
| CA2001434C (en) | 1995-09-12 |
| JPH074273B2 (ja) | 1995-01-25 |
| AU4517489A (en) | 1990-05-14 |
| DK152890A (da) | 1990-06-22 |
| EP0404887B1 (de) | 1994-05-18 |
| CA2001434A1 (en) | 1990-04-26 |
| IL92099A0 (en) | 1990-07-12 |
| HK115694A (en) | 1994-10-27 |
| DE68915437T2 (de) | 1994-09-29 |
| WO1990004787A1 (en) | 1990-05-03 |
| NZ231133A (en) | 1991-10-25 |
| ATE105936T1 (de) | 1994-06-15 |
| EP0404887A4 (en) | 1991-04-03 |
| AU626346B2 (en) | 1992-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH1 | Patent not in force |