IL91672A - 11-beta-phenyl-14-beta-H steroids, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

11-beta-phenyl-14-beta-H steroids, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL91672A
IL91672A IL9167289A IL9167289A IL91672A IL 91672 A IL91672 A IL 91672A IL 9167289 A IL9167289 A IL 9167289A IL 9167289 A IL9167289 A IL 9167289A IL 91672 A IL91672 A IL 91672A
Authority
IL
Israel
Prior art keywords
radical
stands
hydroxy
compound
llbeta
Prior art date
Application number
IL9167289A
Other languages
English (en)
Other versions
IL91672A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL91672A0 publication Critical patent/IL91672A0/xx
Publication of IL91672A publication Critical patent/IL91672A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL9167289A 1988-09-20 1989-09-18 11-beta-phenyl-14-beta-H steroids, processes for the preparation thereof and pharmaceutical compositions containing the same IL91672A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3832303A DE3832303A1 (de) 1988-09-20 1988-09-20 11ss-phenyl-14ssh-steroide

Publications (2)

Publication Number Publication Date
IL91672A0 IL91672A0 (en) 1990-04-29
IL91672A true IL91672A (en) 1994-12-29

Family

ID=6363531

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9167289A IL91672A (en) 1988-09-20 1989-09-18 11-beta-phenyl-14-beta-H steroids, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (17)

Country Link
US (1) US5244886A (pt)
EP (1) EP0360369B1 (pt)
JP (1) JP2760870B2 (pt)
AT (1) ATE122052T1 (pt)
AU (1) AU640616B2 (pt)
CA (1) CA1339924C (pt)
DD (1) DD284682A5 (pt)
DE (2) DE3832303A1 (pt)
DK (1) DK50491A (pt)
ES (1) ES2074073T3 (pt)
HU (1) HU208151B (pt)
IE (1) IE67514B1 (pt)
IL (1) IL91672A (pt)
NO (1) NO301119B1 (pt)
PT (1) PT91746B (pt)
WO (1) WO1990003385A1 (pt)
ZA (1) ZA897191B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
DE4042004A1 (de) * 1990-12-22 1992-06-25 Schering Ag 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
DE4038128A1 (de) * 1990-11-27 1992-06-04 Schering Ag 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE4232681C2 (de) * 1992-09-29 1994-11-24 Sigma Tau Ind Farmaceuti 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung
DE4235220A1 (de) * 1992-10-13 1994-06-16 Schering Ag Gestagen wirksame 19,11ß-überbrückte 4-Estrene
DE69500542T2 (de) * 1994-05-19 1998-01-02 Akzo Nobel Nv 11,21-Bisphenyl-19-nor-pregnan Derivate
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
AU710139B2 (en) * 1996-05-01 1999-09-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
EP1079859B1 (en) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
MX343130B (es) 2006-10-24 2016-10-26 Repros Therapeutics Inc Composiciones y métodos para suprimir la proliferación endometrial.
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20130018027A1 (en) 2010-03-22 2013-01-17 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3461090D1 (en) * 1983-02-18 1986-12-04 Schering Ag 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
ES8502612A1 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3708942A1 (de) * 1987-03-18 1988-09-29 Schering Ag 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3917274A1 (de) * 1989-05-24 1990-11-29 Schering Ag 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
NO911102D0 (no) 1991-03-19
NO301119B1 (no) 1997-09-15
CA1339924C (en) 1998-06-23
PT91746A (pt) 1990-03-30
HU895541D0 (en) 1991-08-28
DK50491D0 (da) 1991-03-20
DE3832303A1 (de) 1990-04-12
WO1990003385A1 (de) 1990-04-05
DK50491A (da) 1991-03-20
ATE122052T1 (de) 1995-05-15
EP0360369B1 (de) 1995-05-03
AU4304989A (en) 1990-04-18
ZA897191B (en) 1990-10-31
ES2074073T3 (es) 1995-09-01
JP2760870B2 (ja) 1998-06-04
HU208151B (en) 1993-08-30
JPH04501712A (ja) 1992-03-26
AU640616B2 (en) 1993-09-02
EP0360369A1 (de) 1990-03-28
IE893002L (en) 1990-03-20
HUT56851A (en) 1991-10-28
NO911102L (no) 1991-03-19
US5244886A (en) 1993-09-14
DD284682A5 (de) 1990-11-21
DE58909213D1 (de) 1995-06-14
IL91672A0 (en) 1990-04-29
IE67514B1 (en) 1996-04-03
PT91746B (pt) 1995-05-31

Similar Documents

Publication Publication Date Title
CA1289944C (en) 11 .beta.-(4-ISOPREPENYLPHENYL)ESTRA-4,9-DIENES, THEIR PRODUCTION, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME
JP2588267B2 (ja) １９，１１β―架橋ステロイド，その製造法および該化合物を含有する製薬学的調剤
US5244886A (en) 11β-phenyl-14βH steroids
CA2019404C (en) 11 beta-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents
US5232915A (en) 9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids
DE4042004A1 (de) 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
EP0565553B1 (de) 6,7-MODIFIZIERTE 11$g(b)-ARYL-4-ESTRENE
US5519027A (en) D-homo-(16-ene)-11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents
US5446178A (en) Process for preparing 19,11β-bridged steroids
FI110688B (fi) 11 beta-aryyli-4-estreenejä ja menetelmä niiden valmistamiseksi
NO301120B1 (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 11<beta>-fenyl-14<beta>H-steroider
PT100055B (pt) D-homo-(16-eno)-11b-aril-4-estrenos, processo para a sua preparacao bem como a sua utilizacao como medicamentos
NO172587B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive steroider med 19,11beta-brubinding

Legal Events

Date Code Title Description
KB Patent renewed
RH1 Patent not in force