IL89752A - תולדות של חומצה 1-הידרוקסי-3-)1(-פירולידיניל(- פרופילידן-1,1-ביספוספונית, ייצורן ותכשירי רוקחות המכילים אותן - Google Patents

תולדות של חומצה 1-הידרוקסי-3-)1(-פירולידיניל(- פרופילידן-1,1-ביספוספונית, ייצורן ותכשירי רוקחות המכילים אותן

Info

Publication number
IL89752A
IL89752A IL8975289A IL8975289A IL89752A IL 89752 A IL89752 A IL 89752A IL 8975289 A IL8975289 A IL 8975289A IL 8975289 A IL8975289 A IL 8975289A IL 89752 A IL89752 A IL 89752A
Authority
IL
Israel
Prior art keywords
compound
hydroxy
formula
pyrrolidinyl
propylidene
Prior art date
Application number
IL8975289A
Other languages
English (en)
Other versions
IL89752A0 (en
Original Assignee
Wexport Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wexport Limited filed Critical Wexport Limited
Publication of IL89752A0 publication Critical patent/IL89752A0/xx
Publication of IL89752A publication Critical patent/IL89752A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL8975289A 1988-04-07 1989-03-27 תולדות של חומצה 1-הידרוקסי-3-)1(-פירולידיניל(- פרופילידן-1,1-ביספוספונית, ייצורן ותכשירי רוקחות המכילים אותן IL89752A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808138A GB8808138D0 (en) 1988-04-07 1988-04-07 Chemical compounds

Publications (2)

Publication Number Publication Date
IL89752A0 IL89752A0 (en) 1989-09-28
IL89752A true IL89752A (he) 1994-02-27

Family

ID=10634725

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8975289A IL89752A (he) 1988-04-07 1989-03-27 תולדות של חומצה 1-הידרוקסי-3-)1(-פירולידיניל(- פרופילידן-1,1-ביספוספונית, ייצורן ותכשירי רוקחות המכילים אותן

Country Status (12)

Country Link
US (1) US5130304A (he)
EP (1) EP0409881B1 (he)
JP (1) JP2701952B2 (he)
KR (1) KR0171570B1 (he)
AU (1) AU625757B2 (he)
CA (1) CA1336978C (he)
GB (1) GB8808138D0 (he)
IE (1) IE62212B1 (he)
IL (1) IL89752A (he)
NZ (1) NZ228567A (he)
WO (1) WO1989009775A1 (he)
ZA (1) ZA892465B (he)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05163150A (ja) * 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
JP3141053B2 (ja) * 1991-12-26 2001-03-05 アベンティス ファーマ株式会社 ビスホスホン酸誘導体
US5317015A (en) * 1992-05-01 1994-05-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Azacyclic bisphosphonates as anticholesterolemic agents
JPH07506569A (ja) * 1992-05-29 1995-07-20 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド 異常カルシウム及びリン酸代謝と歯石及び歯垢を治療するための四級窒素含有ホスホネート化合物
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
DE69309842T2 (de) * 1992-10-09 1997-10-16 Elf Antar France Aminephosphate mit einem Imid Endring, deren Herstellung, und deren Verwendung als Zusätze für Motorkraftstoffe
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5652227A (en) * 1995-01-30 1997-07-29 Teronen; Olli Pekka Inhibition of the degradation of connective tissue matrix protein components in mammals
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
US6896871B2 (en) 1998-04-02 2005-05-24 Mbc Research, Inc. Biphosphonate conjugates and methods of making and using the same
US6750340B2 (en) 1998-04-02 2004-06-15 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
US6214812B1 (en) * 1998-04-02 2001-04-10 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
US7598246B2 (en) * 1998-04-02 2009-10-06 Mbc Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
ES2530791T3 (es) 2002-12-20 2015-03-05 Hoffmann La Roche Formulación de ibandronato de altas dosis
ES2537216T3 (es) 2009-09-01 2015-06-03 Duke University Composiciones de bisfosfonato y métodos para tratar la insuficiencia cardíaca
CN102453050B (zh) * 2010-11-03 2015-01-07 成都云克药业有限责任公司 一种二膦酸化合物及其制备方法
AU2012290089B2 (en) 2011-08-01 2016-09-29 Mbc Pharma, Inc. Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
US9949992B2 (en) 2011-11-16 2018-04-24 Duke University Bisphosphonate compositions and methods for treating and\or reducing cardiac dysfunction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1002300A1 (ru) * 1981-10-29 1983-03-07 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова Способ получени @ -аминозамещенных- @ -оксипропилидендифосфоновых кислот
DE3770787D1 (en) * 1986-11-21 1991-07-18 Ciba Geigy Ag Aromatisch substituierte azacyclo-alkylalkandiphosphonsaeuren.
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ZA892465B (en) 1989-12-27
IE890991L (en) 1989-10-07
KR0171570B1 (ko) 1999-05-01
KR900700492A (ko) 1990-08-13
JP2701952B2 (ja) 1998-01-21
EP0409881B1 (en) 1993-02-10
AU3429489A (en) 1989-11-03
AU625757B2 (en) 1992-07-16
IE62212B1 (en) 1995-01-11
JPH03503643A (ja) 1991-08-15
NZ228567A (en) 1991-09-25
US5130304A (en) 1992-07-14
WO1989009775A1 (en) 1989-10-19
IL89752A0 (en) 1989-09-28
EP0409881A1 (en) 1991-01-30
GB8808138D0 (en) 1988-05-11
CA1336978C (en) 1995-09-12

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Legal Events

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KB Patent renewed
RH1 Patent not in force