IL88971A - Disubstituted pyridines, process and intermediates, their preparation and pharmaceutical compositions containing them - Google Patents
Disubstituted pyridines, process and intermediates, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL88971A IL88971A IL8988971A IL8897189A IL88971A IL 88971 A IL88971 A IL 88971A IL 8988971 A IL8988971 A IL 8988971A IL 8897189 A IL8897189 A IL 8897189A IL 88971 A IL88971 A IL 88971A
- Authority
- IL
- Israel
- Prior art keywords
- intermediates
- preparation
- pharmaceutical compositions
- compositions containing
- disubstituted pyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3801440A DE3801440A1 (de) | 1988-01-20 | 1988-01-20 | Disubstituierte pyridine |
IT8821587A IT8821587A0 (it) | 1988-07-29 | 1988-07-29 | Piridine disostituite. |
Publications (2)
Publication Number | Publication Date |
---|---|
IL88971A0 IL88971A0 (en) | 1989-08-15 |
IL88971A true IL88971A (en) | 1993-07-08 |
Family
ID=25864088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL8988971A IL88971A (en) | 1988-01-20 | 1989-01-17 | Disubstituted pyridines, process and intermediates, their preparation and pharmaceutical compositions containing them |
Country Status (16)
Country | Link |
---|---|
US (1) | US4968689A (da) |
EP (1) | EP0325129B1 (da) |
JP (1) | JP2712107B2 (da) |
KR (1) | KR890011847A (da) |
CN (1) | CN1034716A (da) |
AT (1) | ATE111081T1 (da) |
AU (1) | AU614810B2 (da) |
DE (1) | DE58908290D1 (da) |
DK (1) | DK23289A (da) |
ES (1) | ES2058343T3 (da) |
FI (1) | FI92195C (da) |
HU (1) | HU208691B (da) |
IL (1) | IL88971A (da) |
NO (1) | NO890046L (da) |
NZ (1) | NZ227636A (da) |
PT (1) | PT89478B (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3505382A1 (de) * | 1985-02-16 | 1986-08-21 | Accord-Landmaschinen Heinrich Weiste & Co Gmbh, 4770 Soest | Zweischeibenduengerstreuer |
NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
DE3925636A1 (de) * | 1989-08-03 | 1991-02-07 | Bayer Ag | Imino-substituierte pyridine |
US5183897A (en) * | 1989-08-03 | 1993-02-02 | Bayer Aktiengesellschaft | Certain intermediate imino-substituted pyridines |
DE3929507A1 (de) * | 1989-09-06 | 1991-03-07 | Bayer Ag | Substituierte amino-pyridine |
DE59410255D1 (de) * | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
US6620821B2 (en) | 2000-06-15 | 2003-09-16 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US6812345B2 (en) | 2000-06-15 | 2004-11-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US6627636B2 (en) | 2000-06-15 | 2003-09-30 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
DE10135013A1 (de) * | 2001-07-18 | 2003-01-30 | Bayer Ag | Herstellung von Pyridylverbindungen |
US7659281B2 (en) | 2006-04-25 | 2010-02-09 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0098690B1 (en) * | 1982-06-14 | 1987-09-09 | Takeda Chemical Industries, Ltd. | Vinyl carboxylic acid derivatives, their production and use |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
-
1989
- 1989-01-05 NO NO89890046A patent/NO890046L/no unknown
- 1989-01-09 DE DE58908290T patent/DE58908290D1/de not_active Expired - Fee Related
- 1989-01-09 ES ES89100249T patent/ES2058343T3/es not_active Expired - Lifetime
- 1989-01-09 AT AT89100249T patent/ATE111081T1/de active
- 1989-01-09 EP EP89100249A patent/EP0325129B1/de not_active Expired - Lifetime
- 1989-01-17 NZ NZ227636A patent/NZ227636A/en unknown
- 1989-01-17 US US07/298,453 patent/US4968689A/en not_active Expired - Fee Related
- 1989-01-17 IL IL8988971A patent/IL88971A/xx unknown
- 1989-01-18 FI FI890257A patent/FI92195C/fi not_active IP Right Cessation
- 1989-01-18 PT PT89478A patent/PT89478B/pt not_active IP Right Cessation
- 1989-01-19 KR KR1019890000549A patent/KR890011847A/ko not_active Application Discontinuation
- 1989-01-19 HU HU89213A patent/HU208691B/hu not_active IP Right Cessation
- 1989-01-19 JP JP1008769A patent/JP2712107B2/ja not_active Expired - Lifetime
- 1989-01-19 AU AU28613/89A patent/AU614810B2/en not_active Ceased
- 1989-01-19 DK DK023289A patent/DK23289A/da not_active Application Discontinuation
- 1989-01-20 CN CN89100406A patent/CN1034716A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
NO890046L (no) | 1989-07-21 |
FI890257A0 (fi) | 1989-01-18 |
JPH021478A (ja) | 1990-01-05 |
NZ227636A (en) | 1990-09-26 |
EP0325129B1 (de) | 1994-09-07 |
PT89478A (pt) | 1989-10-04 |
CN1034716A (zh) | 1989-08-16 |
ES2058343T3 (es) | 1994-11-01 |
AU614810B2 (en) | 1991-09-12 |
EP0325129A2 (de) | 1989-07-26 |
HU208691B (en) | 1993-12-28 |
PT89478B (pt) | 1993-12-31 |
FI890257A (fi) | 1989-07-21 |
DK23289A (da) | 1989-07-21 |
DE58908290D1 (de) | 1994-10-13 |
AU2861389A (en) | 1989-07-20 |
EP0325129A3 (en) | 1990-12-19 |
NO890046D0 (no) | 1989-01-05 |
HUT50775A (en) | 1990-03-28 |
FI92195C (fi) | 1994-10-10 |
US4968689A (en) | 1990-11-06 |
KR890011847A (ko) | 1989-08-22 |
IL88971A0 (en) | 1989-08-15 |
ATE111081T1 (de) | 1994-09-15 |
DK23289D0 (da) | 1989-01-19 |
FI92195B (fi) | 1994-06-30 |
JP2712107B2 (ja) | 1998-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CS782686A2 (en) | Method of benzimidazole derivatives production | |
EP0337256A3 (de) | Verfahren zur Herstellung pharmazeutischer Mischungen | |
FR2680507B1 (fr) | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
HUT51269A (en) | Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same | |
PL314187A1 (en) | Novel derivatives of pyrazine carboxamide, method of obtaining them and their application in pharmaceutical composition | |
HUT49600A (en) | Process for producing substituted flavonoid deriatives and salts, thereof, as well as pharmaceutical compositions comprising such compounds | |
FR2679906B1 (fr) | Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
IL88971A (en) | Disubstituted pyridines, process and intermediates, their preparation and pharmaceutical compositions containing them | |
JO1406B1 (en) | Chemical compounds | |
ES483661A1 (es) | Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidos | |
ES8301244A1 (es) | Procedimiento para la obtencion de derivados de sisomicina. | |
GR3020575T3 (en) | New 2-amino-5-cyano-1,4-dihydropyridines, process for their preparation and use in pharmaceutical compositions | |
HUT47096A (en) | Process for producing 1,2-dithiol-3-thion derivatives and pharmaceutical compositions containing them as active components | |
DE3371515D1 (en) | Cycloalkyl derivatives of benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them | |
PT87301A (pt) | Process for the preparation of 1,3-dioxanes by products and of pharmaceutical compounds containing them | |
HUT50633A (en) | Process for producing pharmaceutical compositions comprising 1,4-dihydropyridine derivatives | |
EP0386920A3 (en) | 2-hydroxy-3-thienyloxypropylamino derivatives | |
MY103593A (en) | Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation | |
ES8801624A1 (es) | Procedimiento para preparar disulfuros heterociclicos | |
HUT51641A (en) | Process for producing pseudoprimycin and its components, as well as pharmaceutical compositions comprising such active ingredient | |
JO1519B1 (en) | New compounds (new benzimidazole derivatives are effective as ulcers) |