DK23289D0 - Disubstituerede pyridinderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt deres anvendelse - Google Patents

Disubstituerede pyridinderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt deres anvendelse

Info

Publication number
DK23289D0
DK23289D0 DK023289A DK23289A DK23289D0 DK 23289 D0 DK23289 D0 DK 23289D0 DK 023289 A DK023289 A DK 023289A DK 23289 A DK23289 A DK 23289A DK 23289 D0 DK23289 D0 DK 23289D0
Authority
DK
Denmark
Prior art keywords
intermediates
procedures
preparation
pyridine derivatives
disubstituted pyridine
Prior art date
Application number
DK023289A
Other languages
English (en)
Other versions
DK23289A (da
Inventor
Rolf Angerbauer
Peter Fey
Walter Huebsch
Thomas Philipps
Hilmar Bischoff
Dieter Petzinna
Delf Schmidt
Guenter Thomas
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3801440A external-priority patent/DE3801440A1/de
Priority claimed from IT8821587A external-priority patent/IT8821587A0/it
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK23289D0 publication Critical patent/DK23289D0/da
Publication of DK23289A publication Critical patent/DK23289A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
DK023289A 1988-01-20 1989-01-19 Disubstituerede pyridinderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt deres anvendelse DK23289A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3801440A DE3801440A1 (de) 1988-01-20 1988-01-20 Disubstituierte pyridine
IT8821587A IT8821587A0 (it) 1988-07-29 1988-07-29 Piridine disostituite.

Publications (2)

Publication Number Publication Date
DK23289D0 true DK23289D0 (da) 1989-01-19
DK23289A DK23289A (da) 1989-07-21

Family

ID=25864088

Family Applications (1)

Application Number Title Priority Date Filing Date
DK023289A DK23289A (da) 1988-01-20 1989-01-19 Disubstituerede pyridinderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt deres anvendelse

Country Status (16)

Country Link
US (1) US4968689A (da)
EP (1) EP0325129B1 (da)
JP (1) JP2712107B2 (da)
KR (1) KR890011847A (da)
CN (1) CN1034716A (da)
AT (1) ATE111081T1 (da)
AU (1) AU614810B2 (da)
DE (1) DE58908290D1 (da)
DK (1) DK23289A (da)
ES (1) ES2058343T3 (da)
FI (1) FI92195C (da)
HU (1) HU208691B (da)
IL (1) IL88971A (da)
NO (1) NO890046L (da)
NZ (1) NZ227636A (da)
PT (1) PT89478B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505382C2 (de) * 1985-02-16 1990-10-04 Accord-Landmaschinen Heinrich Weiste & Co Gmbh, 4770 Soest Zweischeibendüngerstreuer
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5183897A (en) * 1989-08-03 1993-02-02 Bayer Aktiengesellschaft Certain intermediate imino-substituted pyridines
DE3925636A1 (de) * 1989-08-03 1991-02-07 Bayer Ag Imino-substituierte pyridine
DE3929507A1 (de) * 1989-09-06 1991-03-07 Bayer Ag Substituierte amino-pyridine
ES2193148T3 (es) * 1993-12-10 2003-11-01 Bayer Ag 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral.
AR008789A1 (es) * 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US6627636B2 (en) 2000-06-15 2003-09-30 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US6620821B2 (en) 2000-06-15 2003-09-16 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US6812345B2 (en) 2000-06-15 2004-11-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
DE10135013A1 (de) * 2001-07-18 2003-01-30 Bayer Ag Herstellung von Pyridylverbindungen
US7659281B2 (en) 2006-04-25 2010-02-09 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098690B1 (en) * 1982-06-14 1987-09-09 Takeda Chemical Industries, Ltd. Vinyl carboxylic acid derivatives, their production and use
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen

Also Published As

Publication number Publication date
US4968689A (en) 1990-11-06
FI92195C (fi) 1994-10-10
ATE111081T1 (de) 1994-09-15
IL88971A0 (en) 1989-08-15
NZ227636A (en) 1990-09-26
HUT50775A (en) 1990-03-28
FI890257A0 (fi) 1989-01-18
EP0325129A2 (de) 1989-07-26
EP0325129B1 (de) 1994-09-07
FI890257A (fi) 1989-07-21
NO890046L (no) 1989-07-21
JPH021478A (ja) 1990-01-05
JP2712107B2 (ja) 1998-02-10
KR890011847A (ko) 1989-08-22
ES2058343T3 (es) 1994-11-01
PT89478A (pt) 1989-10-04
EP0325129A3 (en) 1990-12-19
DE58908290D1 (de) 1994-10-13
FI92195B (fi) 1994-06-30
CN1034716A (zh) 1989-08-16
DK23289A (da) 1989-07-21
IL88971A (en) 1993-07-08
HU208691B (en) 1993-12-28
AU614810B2 (en) 1991-09-12
AU2861389A (en) 1989-07-20
NO890046D0 (no) 1989-01-05
PT89478B (pt) 1993-12-31

Similar Documents

Publication Publication Date Title
NO884625D0 (no) N-substituerte derivater av 1-desoksynojirimycin og 1-desoksymannojirimycin, fremgangsmaate for deres fremstilling og deres anvendelse i legemiddel.
NO305657B1 (no) 4-substituerte piperidinderivater og farmas°ytisk preparat derav
NO172344C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte flavonoidforbindelser og salter
DK23289A (da) Disubstituerede pyridinderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt deres anvendelse
DK143588A (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
FI913943A0 (fi) Nya kroman- och tiokromanderivat.
DK217588D0 (da) 17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler
DK53285A (da) (-)-trans-4(4-fluorphenyl)-3-(4-methoxyphenoxy)-methylpiperidin, farmaceutisk acceptable syreadditionssalte heraf og farmaceutisk praeparat indeholdende samme
DK300688D0 (da) Heterocycliske hydroxyethylazolderivater, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
DK0479093T3 (da) Oligosaccharidderivater og deres anvendelse som lægemidler
DK5379A (da) 1-aza-(2,2,2)-bicyclooctanderivater mellemprodukter hertil og fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
DK219685D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK536488A (da) Alkadienderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt laegemidler deraf
DK619286A (da) Pyridin-derivater og n-oxider deraf, fremgangsmaader til deres fremstilling og deres anvendelse som mellemprodukter
DK361288A (da) Hydroxyethylazolylderivater, deres fremstilling og anvendelse samt mellemprodukter til fremstilling og disses fremstilling
DK284688A (da) Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler
IT7826263A0 (it) Derivati del piranocromone e composizione terapeutica comprendente gli stessi, per il trattamento di malattie allergiche.
DK0427526T3 (da) Pyridinderivater, fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf
DK501888A (da) 6-mercaptopurin-derivater, deres fremstilling og anvendelse som laegemidler
NO163777C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive dioksino-(4,5-c)-pyridin-derivater.
DK111987D0 (da) 4-(2-pyrimidinyl)-1-piperazinyl-hererocycliske carbonylderivater, deres fremstilling og anvendelse som laegemidler
ES472771A1 (es) Procedimiento para la obtencion de 2-piridin-1,4-dihidropi- ridinas
DK624288D0 (da) 3-substituerede pyridiner, fremgangsmaader til deres fremstilling samt deres anvendelse
NL7613657A (nl) Werkwijze voor het bereiden van piperidinede- rivaten, werkwijze voor het bereiden van farma- ceutische preparaten met toepassing daarvan als- mede zo gevormde preparaten.
DK436588D0 (da) Substituerede pyridiner, fremgangsmaader til deres fremstilling samt deres anvendelse

Legal Events

Date Code Title Description
ATS Application withdrawn