IL85599A - Method,apparatus and kits for determining the interaction of tissue and various agents - Google Patents

Method,apparatus and kits for determining the interaction of tissue and various agents

Info

Publication number
IL85599A
IL85599A IL85599A IL8559988A IL85599A IL 85599 A IL85599 A IL 85599A IL 85599 A IL85599 A IL 85599A IL 8559988 A IL8559988 A IL 8559988A IL 85599 A IL85599 A IL 85599A
Authority
IL
Israel
Prior art keywords
tissue
kits
interaction
determining
various agents
Prior art date
Application number
IL85599A
Other languages
English (en)
Other versions
IL85599A0 (en
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL85599(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of IL85599A0 publication Critical patent/IL85599A0/xx
Publication of IL85599A publication Critical patent/IL85599A/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
IL85599A 1987-03-31 1988-03-01 Method,apparatus and kits for determining the interaction of tissue and various agents IL85599A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/032,848 US4835102A (en) 1987-03-31 1987-03-31 Tissue equivalent test systems

Publications (2)

Publication Number Publication Date
IL85599A0 IL85599A0 (en) 1988-08-31
IL85599A true IL85599A (en) 1991-11-21

Family

ID=21867144

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85599A IL85599A (en) 1987-03-31 1988-03-01 Method,apparatus and kits for determining the interaction of tissue and various agents

Country Status (9)

Country Link
US (1) US4835102A (de)
EP (1) EP0295762B1 (de)
JP (1) JP2767803B2 (de)
AT (1) ATE156915T1 (de)
CA (1) CA1305913C (de)
DE (1) DE3855991T2 (de)
ES (1) ES2106010T3 (de)
GR (1) GR3025046T3 (de)
IL (1) IL85599A (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5510254A (en) * 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5053340A (en) * 1989-02-24 1991-10-01 National Testing Corporation In vitro test for dermal toxic properties
US5175092A (en) * 1989-05-04 1992-12-29 Millipore Corporation Vitro toxicology kit and method therefor
DE3923279A1 (de) * 1989-07-14 1990-01-18 Will W Prof Dr Minuth Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren
US5106949A (en) * 1989-09-15 1992-04-21 Organogenesis, Inc. Collagen compositions and methods for preparation thereof
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
DE69128530T2 (de) * 1990-04-24 1998-08-20 Mark Eisenberg Zusammengesetztes äquivalent der lebenden haut
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US5612188A (en) * 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
CA2129350A1 (en) * 1992-02-04 1993-08-05 Jeanne A. Itak Immunological analogs for captan
WO1993017336A1 (en) * 1992-02-19 1993-09-02 The Procter & Gamble Company In vitro model for eye and skin irritation testing
US5478739A (en) * 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5888720A (en) * 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
US5585265A (en) * 1992-11-30 1996-12-17 Gillette Company Human corneal epithelial cell lines with extended lifespan
US5656492A (en) * 1993-02-12 1997-08-12 Brigham And Women's Hospital, Inc. Cell induction device
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
AU8095094A (en) * 1993-10-29 1995-05-22 Invitro International In vitro fluid toxicity bioassay
WO1995014221A1 (en) * 1993-11-18 1995-05-26 Ramsay Hospital Holdings Pty. Ltd. Processing cassette for tissue samples
US5672498A (en) * 1993-12-28 1997-09-30 The Gillete Company Human corneal epithelial cell lines with extended lifespan
DE69532976T2 (de) * 1994-03-14 2005-05-04 Cryolife, Inc. Herstellungsverfahren von gewebe zur implantation
EP0754017B1 (de) * 1994-04-29 2002-06-19 SciMed Life Systems, Inc. Stent mit kollagen
JP2858087B2 (ja) 1994-09-19 1999-02-17 グンゼ株式会社 組織培養用基材及び組織培養法
US5948654A (en) 1996-08-28 1999-09-07 Univ Minnesota Magnetically oriented tissue-equivalent and biopolymer tubes comprising collagen
US6057137A (en) * 1994-10-06 2000-05-02 Regents Of The University Of Minnesota Tissue-equivalent rods containing aligned collagen fibrils and schwann cells
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US20040002772A1 (en) * 1995-04-28 2004-01-01 Organogenesis, Inc. Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents
US5814328A (en) 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
US5846188A (en) * 1997-01-17 1998-12-08 Palti; Yoram Sensor utilizing living muscle cells
CA2283795C (en) 1997-03-11 2011-10-04 Pola Chemical Industries Inc. Method for evaluation of skin conditioning-ameliorating agents and method of producing compositions for topical application to skin
US7687057B2 (en) * 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6066495A (en) * 1998-03-05 2000-05-23 Tissue Engineering, Inc. Methods and apparatus for the conditioning of ligament replacement tissue
AU3077299A (en) 1998-03-11 1999-09-27 University Of Southern California Method of promoting production of living tissue equivalents
US6432710B1 (en) 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US7063726B2 (en) * 1998-06-30 2006-06-20 Lifenet Plasticized bone grafts and methods of making and using same
US6293970B1 (en) * 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
AT407047B (de) * 1998-08-03 2000-11-27 Pfaller Walter Dr Zellkulturvorrichtung
DE69927600T2 (de) 1998-11-19 2006-07-06 Organogenesis, Inc., Canton Biotechnisch konstruiertes gewebe und verfahren zu dessen produktion und benutzung
US6030789A (en) * 1999-03-10 2000-02-29 The Gillette Company Human conjunctival epithelial cell lines with an extended life span
US6287340B1 (en) * 1999-05-14 2001-09-11 Trustees Of Tufts College Bioengineered anterior cruciate ligament
CA2410946A1 (en) * 2000-05-31 2002-11-29 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. In vitro tissue test system
US7172859B2 (en) * 2000-07-14 2007-02-06 Transform Pharmaceuticals, Inc. System and method for optimizing tissue barrier transfer of compounds
US20080182293A1 (en) * 2000-07-14 2008-07-31 Transform Pharmaceuticals, Inc. Computerized control of high-throughput transdermal experimental processing and digital analysis of comparative samples
JP2004504585A (ja) * 2000-07-14 2004-02-12 トランスフォーム　ファーマシューティカルズ，インコーポレーティッド． 化合物の組織バリア輸送を最適にするためのシステムおよび方法
US6852526B2 (en) * 2000-07-14 2005-02-08 Transform Pharmaceuticals, Inc. Transdermal assay with magnetic clamp
WO2003027256A2 (en) * 2001-09-27 2003-04-03 The Wistar Institute Methods and compositions for monitoring cell migration and identifying clinically relevant cytotoxic t lymphocyte activity
US20030166274A1 (en) * 2001-11-15 2003-09-04 Hewitt Charles W. Three-dimensional matrix for producing living tissue equivalents
WO2003089566A1 (en) * 2002-04-22 2003-10-30 Tufts University Multi-dimensional strain bioreactor
AUPS242702A0 (en) * 2002-05-21 2002-06-13 Colltech Australia Limited Improved method for the extraction and purification of collagen
US7229820B2 (en) 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
AU2003242967A1 (en) * 2002-07-12 2004-02-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method and device for inducing biological processes by micro-organs
US6908760B2 (en) * 2002-10-28 2005-06-21 Transform Pharmaceuticals, Inc. Raised surface assay plate
US7449307B2 (en) * 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
US20040185430A1 (en) * 2002-12-20 2004-09-23 Marc Andre Lefebvre Process for evaluating the cosmetic or dermatological activity of a product and use of plant material
US9744043B2 (en) 2007-07-16 2017-08-29 Lifenet Health Crafting of cartilage
US8911995B2 (en) * 2007-08-22 2014-12-16 Probiogen Ag Culture system and method for immunogenicity and immunofunction testing in vitro
CN101939644B (zh) * 2008-01-10 2014-06-11 休雷尔公司 免疫系统模拟装置和方法
US8647861B2 (en) 2008-07-16 2014-02-11 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
WO2011126980A1 (en) * 2010-04-05 2011-10-13 Millipore Corporation Polymeric membranes with human skin like permeability properties and uses thereof
JP6122388B2 (ja) 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
EP2725094A1 (de) * 2012-10-29 2014-04-30 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Epithelgewebemodell
EP3024582A4 (de) 2013-07-22 2017-03-08 President and Fellows of Harvard College Anordnung mikrofluidischer kartuschen
CN106459898A (zh) 2013-12-20 2017-02-22 哈佛大学校长及研究员协会 低剪切微流控装置及其使用方法和制造方法
JP6815985B2 (ja) 2014-07-14 2021-01-20 プレジデント アンド フェローズ オブ ハーバード カレッジ 流体システムおよびマイクロ流体システムの改善された性能のためのシステムおよび方法
US10202569B2 (en) 2015-07-24 2019-02-12 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
WO2018052953A1 (en) 2016-09-13 2018-03-22 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
CN112980690B (zh) * 2019-12-17 2022-10-21 华东数字医学工程研究院 Pdx模型孵育装置和抗肿瘤药物筛选方法
WO2023278815A1 (en) * 2021-07-01 2023-01-05 Upkara, Inc. Device for vitrifying and delivering vitrified bioactive agents

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539716A (en) * 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4546500A (en) * 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4629686A (en) * 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
JPS59500201A (ja) * 1982-02-19 1984-02-16 エンドトロニックス・インコ−ポレ−テッド 生物組織への生理活性物質投与のパターンを制御する方法
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4559299A (en) * 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices
US4734372A (en) * 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
JPS6110136A (ja) * 1984-06-25 1986-01-17 Fumio Itatsu 油圧機器の圧力調整装置
JPS6133593A (ja) * 1984-07-26 1986-02-17 株式会社東芝 防犯装置
JPS6134832A (ja) * 1984-07-26 1986-02-19 Hitachi Ltd 大口径イオン源
US4604346A (en) * 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
US4760020A (en) * 1985-05-03 1988-07-26 Eye Research Institute Of Retina Foundation Method for testing biocompatibility

Also Published As

Publication number Publication date
ES2106010T3 (es) 1997-11-01
EP0295762A2 (de) 1988-12-21
CA1305913C (en) 1992-08-04
EP0295762B1 (de) 1997-08-13
US4835102A (en) 1989-05-30
GR3025046T3 (en) 1998-01-30
EP0295762A3 (de) 1990-07-04
ATE156915T1 (de) 1997-08-15
JP2767803B2 (ja) 1998-06-18
IL85599A0 (en) 1988-08-31
JPS63296699A (ja) 1988-12-02
DE3855991T2 (de) 1998-01-22
DE3855991D1 (de) 1997-09-18

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