IL84841A - 2,3-disubstituted isoxazolidines,a process for their preparation,and pharmaceutical compositions containing them - Google Patents

2,3-disubstituted isoxazolidines,a process for their preparation,and pharmaceutical compositions containing them

Info

Publication number
IL84841A
IL84841A IL84841A IL8484187A IL84841A IL 84841 A IL84841 A IL 84841A IL 84841 A IL84841 A IL 84841A IL 8484187 A IL8484187 A IL 8484187A IL 84841 A IL84841 A IL 84841A
Authority
IL
Israel
Prior art keywords
isoxazolidines
disubstituted
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL84841A
Other languages
English (en)
Other versions
IL84841A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL84841A0 publication Critical patent/IL84841A0/xx
Publication of IL84841A publication Critical patent/IL84841A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL84841A 1986-12-17 1987-12-16 2,3-disubstituted isoxazolidines,a process for their preparation,and pharmaceutical compositions containing them IL84841A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863643012 DE3643012A1 (de) 1986-12-17 1986-12-17 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (2)

Publication Number Publication Date
IL84841A0 IL84841A0 (en) 1988-06-30
IL84841A true IL84841A (en) 1992-07-15

Family

ID=6316346

Family Applications (1)

Application Number Title Priority Date Filing Date
IL84841A IL84841A (en) 1986-12-17 1987-12-16 2,3-disubstituted isoxazolidines,a process for their preparation,and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (2) US5422342A (fi)
EP (1) EP0271865B1 (fi)
JP (1) JP2703912B2 (fi)
KR (1) KR960010349B1 (fi)
AR (1) AR246528A1 (fi)
AT (1) ATE81344T1 (fi)
AU (1) AU599177B2 (fi)
CA (1) CA1338484C (fi)
DE (2) DE3643012A1 (fi)
DK (1) DK171894B1 (fi)
ES (1) ES2052539T3 (fi)
FI (1) FI88303C (fi)
GR (1) GR3006699T3 (fi)
HU (1) HU201961B (fi)
IE (1) IE61034B1 (fi)
IL (1) IL84841A (fi)
NO (1) NO175058B (fi)
NZ (1) NZ222921A (fi)
PH (1) PH24746A (fi)
PT (1) PT86380B (fi)
ZA (1) ZA879400B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818850A1 (de) * 1988-06-03 1989-12-07 Hoechst Ag Oligopeptide mit zyklischen prolin-analogen aminosaeuren
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
DE3842197A1 (de) * 1988-12-15 1990-06-21 Hoechst Ag Rasch spaltbares substrat fuer die hiv-protease
DE4016596A1 (de) * 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CA2456269A1 (en) * 2001-08-23 2003-03-06 The Government Of The United States Of America Methods of inhibiting formation of vascular channels and profileration using pyridinone derivatives
AU2005265131B2 (en) * 2004-06-17 2012-02-23 Infinity Discovery, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
US7842815B2 (en) 2004-06-17 2010-11-30 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
TWI389895B (zh) 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4562187A (en) * 1985-01-22 1985-12-31 Hoechst-Roussel Pharmaceuticals Inc. (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine

Also Published As

Publication number Publication date
AU599177B2 (en) 1990-07-12
DK662087A (da) 1988-06-18
AU8258987A (en) 1988-06-23
IL84841A0 (en) 1988-06-30
HU201961B (en) 1991-01-28
PH24746A (en) 1990-10-01
CA1338484C (en) 1996-07-23
GR3006699T3 (fi) 1993-06-30
EP0271865B1 (de) 1992-10-07
FI88303C (fi) 1993-04-26
DE3782149D1 (fi) 1992-11-12
JPS63165374A (ja) 1988-07-08
DK171894B1 (da) 1997-08-04
NO875263D0 (no) 1987-12-16
PT86380B (pt) 1990-11-20
IE873418L (en) 1988-06-17
NO175058C (fi) 1994-08-24
FI875503A0 (fi) 1987-12-15
ZA879400B (en) 1988-07-27
FI88303B (fi) 1993-01-15
NO175058B (no) 1994-05-16
FI875503A (fi) 1988-06-18
PT86380A (de) 1988-01-01
DE3643012A1 (de) 1988-06-30
ES2052539T3 (es) 1994-07-16
US5422342A (en) 1995-06-06
IE61034B1 (en) 1994-09-07
KR960010349B1 (ko) 1996-07-30
KR880007497A (ko) 1988-08-27
HUT47956A (en) 1989-04-28
NZ222921A (en) 1989-08-29
EP0271865A3 (en) 1990-02-07
EP0271865A2 (de) 1988-06-22
US5610146A (en) 1997-03-11
JP2703912B2 (ja) 1998-01-26
ATE81344T1 (de) 1992-10-15
AR246528A1 (es) 1994-08-31
DK662087D0 (da) 1987-12-16
NO875263L (no) 1988-06-20

Similar Documents

Publication Publication Date Title
DE3666036D1 (en) Phenylethanol aminotetralines, process for their preparation and pharmaceutical compositions containing them
PT84964A (en) Process for the preparation of 1,5-diaryl-3-substituted-pyrazoles and of pharmaceutical compositions containing them
IL85741A0 (en) Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and pharmaceutical compositions containing them
PT83143A (en) Process for preparing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions containing them
IL84841A (en) 2,3-disubstituted isoxazolidines,a process for their preparation,and pharmaceutical compositions containing them
IL85290A0 (en) Substituted 3,4-dihydro-2h-benzopyrans,processes for their preparation and pharmaceutical compositions containing same
IL83413A0 (en) 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
EP0251453A3 (en) Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them
HUT46303A (en) Process for producing 3-/omega-/3,5-di-/tetrabutil/-4-hydroxy-phenyl/-alkanoyl/-pyrroles andtheyr deoxy-analogues and pharmaceutical compositions containing them
IL86027A (en) 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use
IL80835A0 (en) N-(pyrrol-1-yl)pyridinamines,a process for their preparation and pharmaceutical compositions containing them
EP0236929A3 (en) 1,2-dithiol-3-thione derivatives, a process for preparing them and a pharmaceutical composition containing them
HUT44524A (en) Process for producing 1,3-thiazolyl- or 1,3,4-thiadiazolyl- derivatives and pharmaceutical compositions containing them
IL84791A0 (en) Substituted aminopropionamides,process for their preparation and pharmaceutical compositions containing them
IL84955A0 (en) Novel carbamoyloxylabdanes,process for the preparation thereof and pharmaceutical compositions containing them
IL81564A0 (en) Insulin derivatives,a process for their preparation,and pharmaceutical compositions containing them
EP0184841A3 (en) 1,4-dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing same
IL82294A0 (en) 1,3-dihydropyridine derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
DE3568041D1 (en) Sulfonamidines, a process for preparing them and pharmaceutical compositions containing them
IL81978A (en) Indenopyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them
IL90219A0 (en) Hydrazinocarbonyloxylabdanes,a process for their preparation and pharmaceutical compositions containing them
HUT45261A (en) Process for producing 7-oxo-4-thia-1-aza-bicyclo/3.2.0/-hept-2-ene derivatives and pharmaceutical compositions containing them
IL92289A0 (en) 1-aminoalkyl-3-oxysubstituted 4-aryl-1,3,4,5-tetrahydro-2h-1,3-benzodiazepine-2-ones,a process for their preparation and pharmaceutical compositions containing them
HUT44525A (en) Process for producing 1,3,4-thiadiazol derivatives and pharmaceutical compositions containing them
IL87678A (en) N-methylene-2,3 -cycloalkylene- (and 2,3-heteroalkylene) -4-quinolinamines, a process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees