IL83141A - Solutions of oxazophosphorins having improved stability and their preparation - Google Patents

Solutions of oxazophosphorins having improved stability and their preparation

Info

Publication number
IL83141A
IL83141A IL83141A IL8314187A IL83141A IL 83141 A IL83141 A IL 83141A IL 83141 A IL83141 A IL 83141A IL 8314187 A IL8314187 A IL 8314187A IL 83141 A IL83141 A IL 83141A
Authority
IL
Israel
Prior art keywords
solutions
preparation
oxazophosphorins
improved stability
radicals
Prior art date
Application number
IL83141A
Other languages
English (en)
Other versions
IL83141A0 (en
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of IL83141A0 publication Critical patent/IL83141A0/xx
Publication of IL83141A publication Critical patent/IL83141A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
IL83141A 1986-07-11 1987-07-09 Solutions of oxazophosphorins having improved stability and their preparation IL83141A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3623369 1986-07-11

Publications (2)

Publication Number Publication Date
IL83141A0 IL83141A0 (en) 1987-12-31
IL83141A true IL83141A (en) 1992-11-15

Family

ID=6304930

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83141A IL83141A (en) 1986-07-11 1987-07-09 Solutions of oxazophosphorins having improved stability and their preparation

Country Status (16)

Country Link
US (1) US4952575A (ja)
EP (1) EP0254902B1 (ja)
JP (1) JPS6323888A (ja)
KR (1) KR880001282A (ja)
AT (1) ATE66609T1 (ja)
AU (1) AU598282B2 (ja)
CA (1) CA1289886C (ja)
DE (2) DE3772482D1 (ja)
DK (1) DK168322B1 (ja)
ES (1) ES2038623T3 (ja)
FI (1) FI86690C (ja)
GR (1) GR3002618T3 (ja)
IE (1) IE59897B1 (ja)
IL (1) IL83141A (ja)
PT (1) PT85293B (ja)
ZA (1) ZA875059B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051257A (en) * 1989-05-09 1991-09-24 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
RO113611B1 (ro) * 1990-08-03 1998-09-30 Asta Pharma Ag Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
ATE348621T1 (de) * 1997-10-13 2007-01-15 Stada Arzneimittel Ag Flüssige darreichungsformen oxazaphosphorinhaltiger pharmazeutischer produkte
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
AUPQ849900A0 (en) * 2000-06-30 2000-07-27 Dbl Australia Pty Ltd. Injectable composition
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
BR0314068A (pt) * 2002-09-05 2005-07-05 Bharat Serums & Vaccines Ltd Processo para a preparação de uma composição estável com baixo nìvel de toxicidade; composição estável que contém oxazafosforina; uso de uma composição estável que contém oxazafosforina; e método de tratamento de uma doença maligna
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
WO2006030450A2 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
KR20170008252A (ko) * 2014-05-09 2017-01-23 아우로메딕스 파마 엘엘씨 사이클로포스파미드 액상 농축 제제
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
WO2016132270A1 (en) * 2015-02-16 2016-08-25 Leiutis Pharmaceuticals Pvt Ltd Stable ready to use cyclophosphamide liquid formulations
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US20230310468A1 (en) * 2020-08-17 2023-10-05 Sandoz Ag Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530147A1 (de) * 1985-08-23 1987-02-26 Bayer Ag Verwendung von diazaphosphorinen zur bekaempfung von endoparasiten

Also Published As

Publication number Publication date
US4952575A (en) 1990-08-28
JPH0543711B2 (ja) 1993-07-02
JPS6323888A (ja) 1988-02-01
EP0254902A2 (de) 1988-02-03
EP0254902A3 (en) 1988-08-03
IE59897B1 (en) 1994-04-20
ES2038623T3 (es) 1993-08-01
DE3772482D1 (de) 1991-10-02
DK359387D0 (da) 1987-07-10
DK359387A (da) 1988-01-12
IE871867L (en) 1988-01-11
PT85293B (pt) 1990-03-30
CA1289886C (en) 1991-10-01
DE3722043A1 (de) 1988-01-14
AU7554987A (en) 1988-01-14
AU598282B2 (en) 1990-06-21
KR880001282A (ko) 1988-04-22
ZA875059B (en) 1988-02-24
PT85293A (de) 1987-08-01
GR3002618T3 (en) 1993-01-25
EP0254902B1 (de) 1991-08-28
IL83141A0 (en) 1987-12-31
FI873064A (fi) 1988-01-12
FI873064A0 (fi) 1987-07-10
ATE66609T1 (de) 1991-09-15
FI86690C (fi) 1992-10-12
DK168322B1 (da) 1994-03-14
FI86690B (fi) 1992-06-30

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Legal Events

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