IL82004A0 - Steroids including a spiro ring in position 17,process and intermediates for their preparation and pharmaceutical compositions containing them - Google Patents

Steroids including a spiro ring in position 17,process and intermediates for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL82004A0
IL82004A0 IL82004A IL8200487A IL82004A0 IL 82004 A0 IL82004 A0 IL 82004A0 IL 82004 A IL82004 A IL 82004A IL 8200487 A IL8200487 A IL 8200487A IL 82004 A0 IL82004 A0 IL 82004A0
Authority
IL
Israel
Prior art keywords
intermediates
preparation
pharmaceutical compositions
compositions containing
spiro ring
Prior art date
Application number
IL82004A
Other languages
English (en)
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IL82004A0 publication Critical patent/IL82004A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL82004A 1986-03-26 1987-03-25 Steroids including a spiro ring in position 17,process and intermediates for their preparation and pharmaceutical compositions containing them IL82004A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8604355A FR2596395B1 (fr) 1986-03-26 1986-03-26 Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant

Publications (1)

Publication Number Publication Date
IL82004A0 true IL82004A0 (en) 1987-10-20

Family

ID=9333576

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82004A IL82004A0 (en) 1986-03-26 1987-03-25 Steroids including a spiro ring in position 17,process and intermediates for their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4900725A (ja)
EP (1) EP0262188B1 (ja)
JP (2) JP2684180B2 (ja)
KR (1) KR880701244A (ja)
CN (1) CN1021445C (ja)
AU (1) AU604692B2 (ja)
CA (1) CA1299169C (ja)
DK (1) DK174211B1 (ja)
ES (1) ES2004268A6 (ja)
FI (1) FI87078C (ja)
FR (1) FR2596395B1 (ja)
GR (1) GR870471B (ja)
HU (1) HU198509B (ja)
IE (1) IE60143B1 (ja)
IL (1) IL82004A0 (ja)
MA (1) MA20918A1 (ja)
MX (1) MX5712A (ja)
NZ (1) NZ219776A (ja)
OA (1) OA08505A (ja)
PH (1) PH25612A (ja)
PT (1) PT84554B (ja)
SU (1) SU1715205A3 (ja)
TN (1) TNSN87042A1 (ja)
TR (1) TR23117A (ja)
WO (1) WO1987005908A1 (ja)
YU (1) YU53387A (ja)
ZA (1) ZA872130B (ja)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306846A3 (de) * 1987-09-11 1990-05-02 Dr. Karl Thomae GmbH Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
FR2651233B1 (fr) * 1989-08-23 1991-12-13 Roussel Uclaf Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
DE69942578D1 (de) 1998-05-22 2010-08-26 Univ R Bifunktionelle moleküle sowie darauf basierende therapien.
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) * 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
FR2789393B1 (fr) * 1999-02-05 2001-10-12 Centre Nat Rech Scient Lactol steroidique
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
GB0711948D0 (en) * 2007-06-20 2007-08-01 Bionature E A Ltd Neurosteriod compounds
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
EA021840B1 (ru) * 2009-09-11 2015-09-30 Бионейчэ Е.А. Лтд. Применение стероидных соединений при воспалительных и аутоиммунных заболеваниях
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509135A (en) * 1968-07-26 1970-04-28 Searle & Co 3-oxygenated 4'-5 - dihydrospiro(estra-4,9-diene-17,2'(3'h)-furans) and congeners
US3764596A (en) * 1971-06-22 1973-10-09 Sandoz Ag 17-dihydrofuranyl-substituted steroids
FR2496669A1 (fr) * 1980-12-23 1982-06-25 Roussel Uclaf Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene

Also Published As

Publication number Publication date
CN1021445C (zh) 1993-06-30
CN87103193A (zh) 1988-01-13
NZ219776A (en) 1990-03-27
WO1987005908A1 (fr) 1987-10-08
EP0262188A1 (fr) 1988-04-06
FR2596395A1 (fr) 1987-10-02
HUT46037A (en) 1988-09-28
JPS63502902A (ja) 1988-10-27
DK618287A (da) 1988-01-22
CA1299169C (fr) 1992-04-21
ES2004268A6 (es) 1988-12-16
PT84554B (pt) 1989-11-10
MX5712A (es) 1993-11-01
FI87078C (fi) 1992-11-25
EP0262188B1 (fr) 1990-11-14
DK174211B1 (da) 2002-09-23
FI875202A0 (fi) 1987-11-25
SU1715205A3 (ru) 1992-02-23
AU7167487A (en) 1987-10-20
GR870471B (en) 1987-07-30
FR2596395B1 (fr) 1989-05-26
JP2652007B2 (ja) 1997-09-10
YU53387A (en) 1988-08-31
ZA872130B (en) 1988-05-25
JPH08311094A (ja) 1996-11-26
FI87078B (fi) 1992-08-14
KR880701244A (ko) 1988-07-26
OA08505A (fr) 1988-07-29
PT84554A (fr) 1987-04-01
TR23117A (tr) 1989-04-03
HU198509B (en) 1989-10-30
JP2684180B2 (ja) 1997-12-03
IE60143B1 (en) 1994-06-01
TNSN87042A1 (fr) 1990-01-01
FI875202A (fi) 1987-11-25
MA20918A1 (fr) 1987-10-01
PH25612A (en) 1991-08-08
US4900725A (en) 1990-02-13
AU604692B2 (en) 1991-01-03
DK618287D0 (da) 1987-11-25
IE870772L (en) 1987-09-26

Similar Documents

Publication Publication Date Title
IL82004A0 (en) Steroids including a spiro ring in position 17,process and intermediates for their preparation and pharmaceutical compositions containing them
EP0263569A3 (en) 9-alpha-hydroxysteroids,process for their preparation,process for the preparation of the corresponding 9(11)-dehydro-derivatives and pharmaceutical preparations containing said steroids
DE3666036D1 (en) Phenylethanol aminotetralines, process for their preparation and pharmaceutical compositions containing them
ZA899434B (en) 9-a2a-3-(oxa-thia)-biocyclo 3,2,1 nonane derivatives,process intermediates for their preparation and pharmaceutical compositions containing them
LTIP1467A (en) Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them
ZA891440B (en) Thienopyridines process and intermediates for their preparation and pharmaceutical composition containing them
IL84863A (en) 3-aryloxy-3-substituted propanamines,process for their preparation and pharmaceutical compositions comprising them
EP0470617A3 (en) 17-substituted corticoid-17-alkylcarbonates, a process for their preparation and pharmaceutical compositions containing them
IL84841A (en) 2,3-disubstituted isoxazolidines,a process for their preparation,and pharmaceutical compositions containing them
AU2224688A (en) New steroids containing a spiro ring 3,4 or 6 links in position 17, the process and intermediates for their preparation, their use as medicaments and the pharmaceutical compositions containing them
EP0442204A3 (en) Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
EP0251453A3 (en) Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them
ZA877453B (en) Tetrahydroquinoline derivatives,a process for their preparation,their use and pharmaceutical formulations containing them
EP0238858A3 (en) A cement composition and a process for preparation thereof
NZ222116A (en) 3-propenylcephem derivatives and pharmaceutical compositions; processes for preparation
PT85910A (en) Piperidin-4-yl-tetracyclic benzodiazepines a process for their preparation and their use as medicaments
EP0236929A3 (en) 1,2-dithiol-3-thione derivatives, a process for preparing them and a pharmaceutical composition containing them
ZA873638B (en) New immunosuppressant substances,process for their preparation and pharmaceutical compositions containing them
IL81564A0 (en) Insulin derivatives,a process for their preparation,and pharmaceutical compositions containing them
IL84791A0 (en) Substituted aminopropionamides,process for their preparation and pharmaceutical compositions containing them
IL93477A0 (en) Steroid derivatives,pharmaceutical compositions containing them and process for their preparation
IL84955A0 (en) Novel carbamoyloxylabdanes,process for the preparation thereof and pharmaceutical compositions containing them
IL82332A0 (en) Benzothiazinone derivatives,process for their preparation and pharmaceutical compositions containing them
IL82333A0 (en) Benzothiazinone derivatives,processes for their preparation and pharmaceutical compositions containing them
IL81978A (en) Indenopyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them