IL81337A - Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them - Google Patents

Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL81337A
IL81337A IL81337A IL8133787A IL81337A IL 81337 A IL81337 A IL 81337A IL 81337 A IL81337 A IL 81337A IL 8133787 A IL8133787 A IL 8133787A IL 81337 A IL81337 A IL 81337A
Authority
IL
Israel
Prior art keywords
hydrogen
immunostimulants
heptanoyl
glu
asp
Prior art date
Application number
IL81337A
Other languages
English (en)
Other versions
IL81337A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL81337A0 publication Critical patent/IL81337A0/xx
Publication of IL81337A publication Critical patent/IL81337A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL81337A 1986-01-23 1987-01-21 Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them IL81337A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1986/000126 WO1987004440A1 (en) 1986-01-23 1986-01-23 Heptanoyl-glu-asp-ala-amino acid immunostimulants

Publications (2)

Publication Number Publication Date
IL81337A0 IL81337A0 (en) 1987-08-31
IL81337A true IL81337A (en) 1991-06-30

Family

ID=22195344

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81337A IL81337A (en) 1986-01-23 1987-01-21 Heptanoyl-glu-asp-ala-amino acid immunostimulants,process for their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US4851388A (ko)
EP (1) EP0231087B1 (ko)
JP (3) JPH0647599B2 (ko)
KR (1) KR900003515B1 (ko)
AT (1) ATE74138T1 (ko)
AU (1) AU568996B2 (ko)
CA (1) CA1295085C (ko)
DE (1) DE3777665D1 (ko)
DK (1) DK34087A (ko)
ES (1) ES2032437T3 (ko)
FI (1) FI874123A0 (ko)
GR (1) GR3004346T3 (ko)
HU (1) HU201094B (ko)
IE (1) IE59174B1 (ko)
IL (1) IL81337A (ko)
NZ (1) NZ219012A (ko)
PT (1) PT84157B (ko)
WO (1) WO1987004440A1 (ko)
ZA (1) ZA87466B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
DE3930739A1 (de) * 1989-09-14 1991-03-28 Sandoz Ag Neue acylpeptide, verfahren zu ihrer herstellung und ihre verwendung
IT1237474B (it) * 1989-10-05 1993-06-07 Polifarma Spa Composti tripeptidici e loro uso farmaceutico come immuno-modulatori
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
US5767086A (en) * 1992-04-03 1998-06-16 Terrapin Technologies, Inc. Bone marrow stimulation by certain glutathione analogs
US5908919A (en) * 1993-10-01 1999-06-01 Terrapin Technologies Urethane mediated, GST specific molecular release systems

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354966A (en) * 1978-11-14 1982-10-19 Fujisawa Pharmaceutical Co., Ltd. Peptides, process for preparation thereof and use thereof
US4411925A (en) * 1980-01-21 1983-10-25 Pfizer Inc. Branched amides of L-aspartyl-d-amino acid dipeptides
US4394308A (en) * 1980-05-27 1983-07-19 Chimicasa Gmbh Method of producing α-L-aspartyl-L-phenylalanine methylesters
GR81332B (ko) * 1980-12-01 1984-12-11 Fujisawa Pharmaceutical Co
US4399066A (en) * 1981-01-29 1983-08-16 Fujisawa Pharmaceutical Co., Ltd. Novel peptide, process for preparation thereof and use thereof
US4619915A (en) * 1984-10-19 1986-10-28 Pfizer Inc. Peptide-substituted heterocyclic immunostimulants
JPS61148198A (ja) * 1984-12-22 1986-07-05 Ajinomoto Co Inc 新規トリペプチド化合物および甘味剤
CA1295784C (en) * 1985-11-25 1992-02-11 James Patrick Rizzi Peptide immunostimulants

Also Published As

Publication number Publication date
KR900003515B1 (ko) 1990-05-21
ES2032437T3 (es) 1993-02-16
DE3777665D1 (de) 1992-04-30
EP0231087B1 (en) 1992-03-25
IE59174B1 (en) 1994-01-26
WO1987004440A1 (en) 1987-07-30
US4851388A (en) 1989-07-25
CA1295085C (en) 1992-01-28
JPH0747600B2 (ja) 1995-05-24
ATE74138T1 (de) 1992-04-15
DK34087A (da) 1987-10-16
IE870169L (en) 1987-07-23
EP0231087A3 (en) 1989-11-23
EP0231087A2 (en) 1987-08-05
JPH0647599B2 (ja) 1994-06-22
AU6790987A (en) 1987-07-30
DK34087D0 (da) 1987-01-22
ZA87466B (en) 1988-07-22
NZ219012A (en) 1988-11-29
KR870007201A (ko) 1987-08-17
HUT46043A (en) 1988-09-28
GR3004346T3 (ko) 1993-03-31
HU201094B (en) 1990-09-28
PT84157B (pt) 1989-07-31
JPS62178600A (ja) 1987-08-05
FI874123A (fi) 1987-09-22
JPH075630B2 (ja) 1995-01-25
PT84157A (en) 1987-02-01
IL81337A0 (en) 1987-08-31
AU568996B2 (en) 1988-01-14
FI874123A0 (fi) 1987-09-22
JPH06122698A (ja) 1994-05-06
JPH06122697A (ja) 1994-05-06

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Legal Events

Date Code Title Description
RH Patent void