IL78885A0 - Removal of the n-terminal methionine from methionyl proteins - Google Patents
Removal of the n-terminal methionine from methionyl proteinsInfo
- Publication number
- IL78885A0 IL78885A0 IL78885A IL7888586A IL78885A0 IL 78885 A0 IL78885 A0 IL 78885A0 IL 78885 A IL78885 A IL 78885A IL 7888586 A IL7888586 A IL 7888586A IL 78885 A0 IL78885 A0 IL 78885A0
- Authority
- IL
- Israel
- Prior art keywords
- methionyl
- proteins
- removal
- terminal methionine
- methionine
- Prior art date
Links
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 title 2
- 229930182817 methionine Natural products 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/11—Aminopeptidases (3.4.11)
- C12Y304/11002—Membrane alanyl aminopeptidase (3.4.11.2), i.e. aminopeptidase N
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1985/000308 WO1986007380A1 (en) | 1985-06-04 | 1985-06-04 | Process for preparing polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
IL78885A0 true IL78885A0 (en) | 1986-09-30 |
Family
ID=13846490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL78885A IL78885A0 (en) | 1985-06-04 | 1986-05-23 | Removal of the n-terminal methionine from methionyl proteins |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0204527A1 (xx) |
JP (1) | JPS62171699A (xx) |
KR (1) | KR870000356A (xx) |
CN (1) | CN86103730A (xx) |
DK (1) | DK260186A (xx) |
ES (1) | ES8708236A1 (xx) |
IE (1) | IE861463L (xx) |
IL (1) | IL78885A0 (xx) |
WO (1) | WO1986007380A1 (xx) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986001229A1 (en) * | 1984-08-16 | 1986-02-27 | Bio-Technology General Corp. | Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby |
US5013662A (en) * | 1985-09-20 | 1991-05-07 | Cetus Corporation | Bacterial methionine n-terminal peptidase |
PT83613B (en) * | 1985-10-28 | 1988-11-21 | Lilly Co Eli | Process for the selective chemical removal of a protein amino-terminal residue |
GB8703015D0 (en) * | 1987-02-10 | 1987-03-18 | Biogen Nv | Aminopeptidase |
DE3811921A1 (de) * | 1988-04-09 | 1989-10-19 | Hoechst Ag | Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen |
GB9225021D0 (en) * | 1992-11-30 | 1993-01-20 | Sandoz Ltd | Organic compounds |
KR970010135B1 (ko) * | 1993-06-17 | 1997-06-21 | 주식회사 엘지화학 | 신규 아미노펩티다제 |
KR100371864B1 (ko) * | 1995-07-31 | 2003-06-02 | 동아제약 주식회사 | 고정화아미노펩티다제엠반응기를이용한천연형인간성장호르몬의생산방법 |
KR100371865B1 (ko) * | 1995-07-31 | 2003-05-23 | 동아제약 주식회사 | 고정화아미노펩티다제엠을이용한천연형인간성장호르몬의제조방법 |
ES2136458T3 (es) | 1996-06-14 | 1999-11-16 | Takeda Chemical Industries Ltd | Metodo para separar la metionina n-terminal. |
KR100449125B1 (ko) * | 1997-04-03 | 2004-11-26 | 동아제약주식회사 | 돼지신장으로부터아미노펩티다제엠의정제방법 |
US6743600B1 (en) | 1999-04-30 | 2004-06-01 | Monsanto Technologies Llc | Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase |
US6794159B1 (en) | 1999-04-30 | 2004-09-21 | Pharmacia Corporation | Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase |
DK1432793T3 (da) * | 2001-09-13 | 2009-12-07 | Genentech Inc | Aminopeptidase b2324 |
KR101041986B1 (ko) | 2008-03-06 | 2011-06-16 | (주)한국비엠아이 | 인간 인터루킨-2의 대량 생산을 위한 신규한 균주 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2922496A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | Verfahren zur spezifischen abspaltung von proteinsequenzen aus proteinen |
IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
US4532207A (en) * | 1982-03-19 | 1985-07-30 | G. D. Searle & Co. | Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase |
DE3374070D1 (en) * | 1982-12-10 | 1987-11-19 | Nordisk Gentofte | A process for preparing ripe proteins from fusion proteins, synthetized in pro- or eukaryotic cells |
WO1986001229A1 (en) * | 1984-08-16 | 1986-02-27 | Bio-Technology General Corp. | Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby |
-
1985
- 1985-06-04 WO PCT/JP1985/000308 patent/WO1986007380A1/ja unknown
-
1986
- 1986-05-23 IL IL78885A patent/IL78885A0/xx unknown
- 1986-05-30 EP EP86304144A patent/EP0204527A1/en not_active Ceased
- 1986-06-03 JP JP61129730A patent/JPS62171699A/ja active Pending
- 1986-06-03 ES ES555649A patent/ES8708236A1/es not_active Expired
- 1986-06-03 DK DK260186A patent/DK260186A/da not_active Application Discontinuation
- 1986-06-03 KR KR1019860004408A patent/KR870000356A/ko not_active IP Right Cessation
- 1986-06-03 IE IE861463A patent/IE861463L/xx unknown
- 1986-06-03 CN CN198686103730A patent/CN86103730A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
DK260186A (da) | 1986-12-05 |
ES8708236A1 (es) | 1987-10-01 |
IE861463L (en) | 1986-12-04 |
DK260186D0 (da) | 1986-06-03 |
EP0204527A1 (en) | 1986-12-10 |
JPS62171699A (ja) | 1987-07-28 |
WO1986007380A1 (en) | 1986-12-18 |
KR870000356A (ko) | 1987-02-18 |
ES555649A0 (es) | 1987-10-01 |
CN86103730A (zh) | 1986-12-17 |
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