DK260186A - Fremgangsmaade til fjernelse af det n-terminale metionin fra metionylproteiner - Google Patents

Fremgangsmaade til fjernelse af det n-terminale metionin fra metionylproteiner Download PDF

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Publication number
DK260186A
DK260186A DK260186A DK260186A DK260186A DK 260186 A DK260186 A DK 260186A DK 260186 A DK260186 A DK 260186A DK 260186 A DK260186 A DK 260186A DK 260186 A DK260186 A DK 260186A
Authority
DK
Denmark
Prior art keywords
metionyl
metionin
proteins
removal
procedure
Prior art date
Application number
DK260186A
Other languages
English (en)
Other versions
DK260186D0 (da
Inventor
Shizue Nakagawa
Takao Yamada
Osamu Nishimura
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK260186D0 publication Critical patent/DK260186D0/da
Publication of DK260186A publication Critical patent/DK260186A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/11—Aminopeptidases (3.4.11)
    • C12Y304/11002—Membrane alanyl aminopeptidase (3.4.11.2), i.e. aminopeptidase N
DK260186A 1985-06-04 1986-06-03 Fremgangsmaade til fjernelse af det n-terminale metionin fra metionylproteiner DK260186A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1985/000308 WO1986007380A1 (en) 1985-06-04 1985-06-04 Process for preparing polypeptide

Publications (2)

Publication Number Publication Date
DK260186D0 DK260186D0 (da) 1986-06-03
DK260186A true DK260186A (da) 1986-12-05

Family

ID=13846490

Family Applications (1)

Application Number Title Priority Date Filing Date
DK260186A DK260186A (da) 1985-06-04 1986-06-03 Fremgangsmaade til fjernelse af det n-terminale metionin fra metionylproteiner

Country Status (9)

Country Link
EP (1) EP0204527A1 (da)
JP (1) JPS62171699A (da)
KR (1) KR870000356A (da)
CN (1) CN86103730A (da)
DK (1) DK260186A (da)
ES (1) ES8708236A1 (da)
IE (1) IE861463L (da)
IL (1) IL78885A0 (da)
WO (1) WO1986007380A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3586773T2 (de) * 1984-08-16 1993-03-18 Bio Technology General Corp Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
US5013662A (en) * 1985-09-20 1991-05-07 Cetus Corporation Bacterial methionine n-terminal peptidase
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
GB8703015D0 (en) * 1987-02-10 1987-03-18 Biogen Nv Aminopeptidase
DE3811921A1 (de) * 1988-04-09 1989-10-19 Hoechst Ag Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen
GB9225021D0 (en) * 1992-11-30 1993-01-20 Sandoz Ltd Organic compounds
KR970010135B1 (ko) * 1993-06-17 1997-06-21 주식회사 엘지화학 신규 아미노펩티다제
KR100371865B1 (ko) * 1995-07-31 2003-05-23 동아제약 주식회사 고정화아미노펩티다제엠을이용한천연형인간성장호르몬의제조방법
KR100371864B1 (ko) * 1995-07-31 2003-06-02 동아제약 주식회사 고정화아미노펩티다제엠반응기를이용한천연형인간성장호르몬의생산방법
ES2136458T3 (es) 1996-06-14 1999-11-16 Takeda Chemical Industries Ltd Metodo para separar la metionina n-terminal.
KR100449125B1 (ko) * 1997-04-03 2004-11-26 동아제약주식회사 돼지신장으로부터아미노펩티다제엠의정제방법
US6743600B1 (en) 1999-04-30 2004-06-01 Monsanto Technologies Llc Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
US6794159B1 (en) 1999-04-30 2004-09-21 Pharmacia Corporation Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
KR100956907B1 (ko) * 2001-09-13 2010-05-11 제넨테크, 인크. 아미노펩티다아제
KR101041986B1 (ko) 2008-03-06 2011-06-16 (주)한국비엠아이 인간 인터루킨-2의 대량 생산을 위한 신규한 균주

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2922496A1 (de) * 1979-05-31 1980-12-04 Schering Ag Verfahren zur spezifischen abspaltung von proteinsequenzen aus proteinen
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
WO1984002351A1 (en) * 1982-12-10 1984-06-21 Nordisk Insulinlab A process for preparing ripe proteins from fusion proteins, synthetized in pro- or eukaryotic cells
DE3586773T2 (de) * 1984-08-16 1993-03-18 Bio Technology General Corp Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.

Also Published As

Publication number Publication date
DK260186D0 (da) 1986-06-03
JPS62171699A (ja) 1987-07-28
IL78885A0 (en) 1986-09-30
EP0204527A1 (en) 1986-12-10
ES8708236A1 (es) 1987-10-01
IE861463L (en) 1986-12-04
CN86103730A (zh) 1986-12-17
WO1986007380A1 (en) 1986-12-18
KR870000356A (ko) 1987-02-18
ES555649A0 (es) 1987-10-01

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