IL77978A0 - Racemization of tomoxetine - Google Patents

Racemization of tomoxetine

Info

Publication number
IL77978A0
IL77978A0 IL77978A IL7797886A IL77978A0 IL 77978 A0 IL77978 A0 IL 77978A0 IL 77978 A IL77978 A IL 77978A IL 7797886 A IL7797886 A IL 7797886A IL 77978 A0 IL77978 A0 IL 77978A0
Authority
IL
Israel
Prior art keywords
tomoxetine
racemization
alkali metal
phenylpropylamine
epimerization
Prior art date
Application number
IL77978A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL77978A0 publication Critical patent/IL77978A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL77978A 1985-02-27 1986-02-25 Racemization of tomoxetine IL77978A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/706,373 US4777291A (en) 1985-02-27 1985-02-27 Racemization process

Publications (1)

Publication Number Publication Date
IL77978A0 true IL77978A0 (en) 1986-08-31

Family

ID=24837278

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77978A IL77978A0 (en) 1985-02-27 1986-02-25 Racemization of tomoxetine

Country Status (9)

Country Link
US (1) US4777291A (xx)
EP (1) EP0193405B1 (xx)
JP (1) JPS61210059A (xx)
KR (1) KR870002180B1 (xx)
AT (1) ATE41144T1 (xx)
CA (1) CA1269997A (xx)
DE (1) DE3662262D1 (xx)
HU (1) HU196586B (xx)
IL (1) IL77978A0 (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419683D0 (en) * 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane
US5320825A (en) * 1991-05-01 1994-06-14 Trustees Of The University Of Pennsylvania Serotonin reuptake inhibitors for S.P.E.C.T. imaging
AU3219800A (en) * 1999-03-29 2000-10-16 Eli Lilly And Company Stereospecific method for preparing tomoxetine and intermediates thereof
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
EP1708717B1 (en) * 2003-07-28 2011-10-05 Leslie Joe Dunaway Atomoxetine for treatment of allergic rhinitis and asthma
EP1715856B1 (en) * 2003-12-31 2012-07-11 Actavis Group PTC ehf. Atomoxetine formulations
EP1687254A2 (en) * 2004-06-28 2006-08-09 Teva Pharmaceutical Fine Chemicals S.R.L. Process for the optical resolution and recycling of tomoxetine
US7439399B2 (en) * 2004-06-28 2008-10-21 Teva Pharmaceutical Fine Chemicals Processes for the preparation of atomoxetine hydrochloride
CN1976894A (zh) 2004-07-22 2007-06-06 特瓦药物精化学品股份有限公司 阿托莫西汀盐酸盐的多形体
WO2006037055A1 (en) * 2004-09-27 2006-04-06 Dr. Reddy's Laboratories Ltd. Synthesis of atomoxetine hydrochloride
US7569729B2 (en) * 2005-04-05 2009-08-04 Teva Pharmaceutical Fine Chemicals S.R.L. Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US7485754B2 (en) * 2005-07-08 2009-02-03 Apotex Pharmachem Inc. Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
US20080146675A1 (en) * 2006-04-05 2008-06-19 Eugenio Castelli Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine
CN113336654B (zh) * 2020-02-18 2022-12-09 上海医药工业研究院 一种n-甲基-3-(2-甲基苯氧基)苯丙胺的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168566A (en) * 1961-09-01 1965-02-02 Nopco Chem Co Process for racemizing alpha-phenyl and alpha-naphthyl ethylamines
IT1020699B (it) * 1973-08-31 1977-12-30 Sumitomo Chemical Co Procedimento per la racemizzazione di ammine otticamente attive
US4158016A (en) * 1973-08-31 1979-06-12 Sumitomo Chemical Company, Limited Method for racemization of optically active amines
DE2348801A1 (de) * 1973-09-28 1975-04-10 Dynamit Nobel Ag Verfahren zur racemisierung von optisch aktivem 1-phenylaethylamin
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
FI77018C (fi) * 1980-11-14 1989-01-10 Lilly Co Eli Analogifoerfarande foer framstaellning av antidepressivt aktiv (-)-enantiomer av n-metyl-n-/3-(2-metylfenoxi) -3-fenylpropyl/amin och dess farmaceutiskt godtagbara salt.

Also Published As

Publication number Publication date
HUT42055A (en) 1987-06-29
KR870002180B1 (ko) 1987-12-28
KR860006433A (ko) 1986-09-11
EP0193405A1 (en) 1986-09-03
ATE41144T1 (de) 1989-03-15
EP0193405B1 (en) 1989-03-08
JPS61210059A (ja) 1986-09-18
HU196586B (en) 1988-12-28
DE3662262D1 (en) 1989-04-13
CA1269997A (en) 1990-06-05
US4777291A (en) 1988-10-11

Similar Documents

Publication Publication Date Title
IL77978A0 (en) Racemization of tomoxetine
PL306068A1 (en) Crystalline compounds, method of obtaining them and pharmaceutic agent containing such compounds
EP0624574A3 (en) Prostaglandin analog.
PT73442A (en) Process for preparing acid stabilised compositions of thieno-pyridine derived compounds
GB1492718A (en) Benzothiazine 1,1-dioxide derivatives
IL81318A0 (en) Method of working up the solution from the enzymatic resolution of a racemate of an n-acetyl-dl-amino carboxylic acid
HUT37444A (en) Process for preparing bestatin derivatives
EP0508133A3 (en) Method of preparation of l-carnitine from d,l-carnitine nitrile salts
DE3160752D1 (en) Compositions to be ingested by ruminants, method of producing them
MY126530A (en) Process for the production of r-(+)-6-carboxamido-3-n-methylamino-1,2,3,4-tetrahydrocarbazole
IE36577B1 (en) D-penicillamine
JPS5215891A (en) Method for preparing l-amino acids
HU9202806D0 (en) Method for separing enenthiomers of 5-hetaryl-1,3,4-thiadiazinone derivatives
EP0170148A3 (en) Process for the preparation of alfa-l-aspartyl-l-phenylalanine alkyl esters
IE800588L (en) Piperidinothiazolidines
JPS545957A (en) Racemization of optical active alpha-naphthylethylamine
JPS51125363A (en) Process for freparation of alkylidenebiscyclohexylamines
JPS5238788A (en) Manufacturing method of vaporized metal discharge lamp
ES502668A0 (es) Procedimiento para preparar una solucion hidrocarbonada de un compuesto de alquilsodio
EP0169725A3 (en) New method of treatment using prostaglandin analogues
EP0202736A3 (en) Synthesis of 3s, 4s-boc-statine
DE3366194D1 (en) L(+)-tartrate dehydrogenase, method for its prepartion, as well as a method and reagent for the determination of l(+)-tartrate and d(+)-malate
JPS51111082A (en) A point contact diode soldering jig
JPS549707A (en) Manufacturing method of yoke for crutched motor
JPS5257171A (en) Process for preparing 2-amino (2) thiazoline-4-carboxylic acid