IL73823A - Substituted spiro pyridine derivatives,pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions - Google Patents

Substituted spiro pyridine derivatives,pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions

Info

Publication number
IL73823A
IL73823A IL73823A IL7382384A IL73823A IL 73823 A IL73823 A IL 73823A IL 73823 A IL73823 A IL 73823A IL 7382384 A IL7382384 A IL 7382384A IL 73823 A IL73823 A IL 73823A
Authority
IL
Israel
Prior art keywords
compounds
processes
preparation
pyridine derivatives
substituted spiro
Prior art date
Application number
IL73823A
Other languages
English (en)
Other versions
IL73823A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/561,416 external-priority patent/US4652564A/en
Priority claimed from US06/641,076 external-priority patent/US4632923A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL73823A0 publication Critical patent/IL73823A0/xx
Publication of IL73823A publication Critical patent/IL73823A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL73823A 1983-12-14 1984-12-14 Substituted spiro pyridine derivatives,pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions IL73823A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/561,416 US4652564A (en) 1983-12-14 1983-12-14 Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents
US06/641,076 US4632923A (en) 1984-08-15 1984-08-15 Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents

Publications (2)

Publication Number Publication Date
IL73823A0 IL73823A0 (en) 1985-03-31
IL73823A true IL73823A (en) 1988-03-31

Family

ID=27072640

Family Applications (1)

Application Number Title Priority Date Filing Date
IL73823A IL73823A (en) 1983-12-14 1984-12-14 Substituted spiro pyridine derivatives,pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions

Country Status (18)

Country Link
EP (1) EP0144996B1 (xx)
JP (1) JPH066586B2 (xx)
KR (1) KR900004832B1 (xx)
AU (1) AU574749B2 (xx)
CA (1) CA1252786A (xx)
DE (1) DE3481418D1 (xx)
DK (1) DK169721B1 (xx)
FI (1) FI79539C (xx)
GB (1) GB2153348B (xx)
GR (1) GR82463B (xx)
HK (1) HK48890A (xx)
HU (1) HU193913B (xx)
IL (1) IL73823A (xx)
MY (1) MY100602A (xx)
NO (1) NO163896C (xx)
NZ (1) NZ210551A (xx)
OA (1) OA07899A (xx)
PT (1) PT79672A (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3669656D1 (de) * 1985-06-18 1990-04-26 Schering Corp Azanaphthalene enthaltende arzneimittelzusammensetzungen.
DE3786036T2 (de) * 1986-04-11 1993-09-09 Schering Corp Arylsubstituierte naphthyridin- und pyridopyrazin-derivate.
US5045542A (en) * 1986-10-20 1991-09-03 Schering Corporation Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives
CA1309658C (en) * 1986-12-05 1992-11-03 David J. Blythin Pharmaceutical compositions for treatment of hyperproliferate skin disease
US5350755A (en) * 1986-12-05 1994-09-27 Schering Corporation Compounds and methods for treating hyperproliferative skin disease
EP1202994B1 (en) 1999-07-21 2004-04-14 AstraZeneca AB New compounds
US7592457B2 (en) * 2004-10-20 2009-09-22 Korea Research Institute Of Chemical Technology 3-aryl-3-methyl-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB855022A (en) * 1957-08-06 1960-11-30 Geigy Ag J R Improvements in and relating to carbostyril derivatives
JPS5089376A (xx) * 1973-12-19 1975-07-17
US4215216A (en) * 1979-04-18 1980-07-29 American Home Products Corporation 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives
EP0092786B1 (en) * 1982-04-26 1987-01-07 Schering Corporation 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives

Also Published As

Publication number Publication date
DE3481418D1 (de) 1990-04-05
OA07899A (fr) 1986-11-20
DK597184D0 (da) 1984-12-13
DK597184A (da) 1985-06-15
NO163896B (no) 1990-04-30
NO845016L (no) 1985-06-17
FI844919A0 (fi) 1984-12-13
NO163896C (no) 1990-08-08
FI79539B (fi) 1989-09-29
JPH066586B2 (ja) 1994-01-26
KR850004487A (ko) 1985-07-15
EP0144996B1 (en) 1990-02-28
EP0144996A3 (en) 1986-06-11
MY100602A (en) 1990-12-15
EP0144996A2 (en) 1985-06-19
PT79672A (en) 1985-01-01
CA1252786A (en) 1989-04-18
NZ210551A (en) 1988-05-30
GB8431542D0 (en) 1985-01-23
FI79539C (fi) 1990-01-10
GB2153348B (en) 1987-08-12
HU193913B (en) 1987-12-28
GB2153348A (en) 1985-08-21
DK169721B1 (da) 1995-01-23
KR900004832B1 (ko) 1990-07-07
HUT36477A (en) 1985-09-30
IL73823A0 (en) 1985-03-31
GR82463B (en) 1985-04-16
HK48890A (en) 1990-06-29
FI844919L (fi) 1985-06-15
AU3662484A (en) 1985-06-20
AU574749B2 (en) 1988-07-14
JPS60156689A (ja) 1985-08-16

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Legal Events

Date Code Title Description
RH Patent void