IL72645A0 - Microbial expression of insulin-like growth factor - Google Patents
Microbial expression of insulin-like growth factorInfo
- Publication number
- IL72645A0 IL72645A0 IL72645A IL7264584A IL72645A0 IL 72645 A0 IL72645 A0 IL 72645A0 IL 72645 A IL72645 A IL 72645A IL 7264584 A IL7264584 A IL 7264584A IL 72645 A0 IL72645 A0 IL 72645A0
- Authority
- IL
- Israel
- Prior art keywords
- insulin
- growth factor
- microbial expression
- microbial
- expression
- Prior art date
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title 1
- 102000013275 Somatomedins Human genes 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52196683A | 1983-08-10 | 1983-08-10 | |
US63345184A | 1984-07-26 | 1984-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL72645A0 true IL72645A0 (en) | 1984-11-30 |
Family
ID=27060652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL72645A IL72645A0 (en) | 1983-08-10 | 1984-08-10 | Microbial expression of insulin-like growth factor |
Country Status (3)
Country | Link |
---|---|
EP (2) | EP0406913A1 (fr) |
IL (1) | IL72645A0 (fr) |
WO (1) | WO1985000831A1 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE95236T1 (de) * | 1983-04-25 | 1993-10-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren. |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
DK108685A (da) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | Vaekstfaktor i |
US4745179A (en) * | 1984-04-02 | 1988-05-17 | Fujisawa Pharmaceutical Co., Ltd. | 59 Valine insulin-like growth factor I and process for production thereof |
ATE64956T1 (de) * | 1984-06-14 | 1991-07-15 | Ciba Geigy Ag | Verfahren zur herstellung von thrombininhibitoren. |
EP0189481B1 (fr) * | 1984-07-13 | 1991-01-23 | Chiron Corporation | Facteur de Croissance II analogue à l'Insuline |
GB8431818D0 (en) * | 1984-12-17 | 1985-01-30 | Bujard H | Expression control sequence |
EP0193112A3 (fr) * | 1985-02-22 | 1987-02-25 | The Trustees Of Columbia University In The City Of New York | cADN codant un facteur mammifère de croissance du genre insuline type II |
ATE81779T1 (de) * | 1985-08-22 | 1992-11-15 | Gropep Pty Ltd | Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren. |
EP0219814B1 (fr) * | 1985-10-21 | 1991-09-11 | Fujisawa Pharmaceutical Co., Ltd. | Procédé de production de facteur I de croissance semblable à l'insuline (IGF-I) et plasmide pour sa production |
AU613876B2 (en) * | 1986-10-01 | 1991-08-15 | Merck & Co., Inc. | Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins |
EP0324789B1 (fr) * | 1986-10-02 | 2003-08-20 | Massachusetts Institute Of Technology | Procede de regulation de la stabilite metabolique de proteines |
US5104796A (en) * | 1987-04-06 | 1992-04-14 | International Minerals & Chemical Corp. | High titer production of human somatomedin c |
DE3805150A1 (de) * | 1987-04-11 | 1988-10-20 | Hoechst Ag | Gentechnologisches verfahren zur herstellung von polypeptiden |
EP0289314B1 (fr) * | 1987-04-28 | 1994-10-12 | Roche Diagnostics GmbH | Emploi de IGF-II pour le traitement de désordres des os |
US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
GB8723660D0 (en) * | 1987-10-08 | 1987-11-11 | British Bio Technology | Synthetic gene |
US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
JP2507106B2 (ja) * | 1987-12-24 | 1996-06-12 | グロペップ プロプライエタリー リミテッド | インスリン様成長因子1(igf―1)または因子2(igf―2)の類縁ペプチド |
GB8927008D0 (en) * | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
US5679771A (en) * | 1990-02-13 | 1997-10-21 | Gropep Pty. Ltd. | Method for treating intestinal diseases |
CA2058041A1 (fr) * | 1990-06-27 | 1991-12-28 | Katsuichi Sakano | Anticorps monoclonaux anti-igf-ii |
AU2368892A (en) * | 1991-07-29 | 1993-03-02 | British Bio-Technology Limited | Igf-ii analogues |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
AU3812993A (en) * | 1992-03-24 | 1993-10-21 | Synergen, Inc. | Refolding and purification of insulin-like growth factor I |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
US5712249A (en) * | 1994-09-08 | 1998-01-27 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
WO1996007744A1 (fr) * | 1994-09-08 | 1996-03-14 | Chiron Corporation | Procede de production amelioree des facteurs de croissance proches de l'insuline |
EP0854884A1 (fr) * | 1996-04-17 | 1998-07-29 | Neurocrine Biosciences, Inc. | Inhibiteurs de ligands inhibant les proteines de liaison du facteur de croissance du type insuline et leurs procedes d'utilisation |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
AU762351B2 (en) | 1999-01-06 | 2003-06-26 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
WO2001087323A2 (fr) | 2000-05-16 | 2001-11-22 | Genentech, Inc. | Procede de traitement des lesions du cartilage |
JP4335130B2 (ja) | 2002-04-30 | 2009-09-30 | 協和発酵キリン株式会社 | ヒトインスリン様成長因子に対する抗体 |
PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
UY32317A (es) | 2008-12-12 | 2010-07-30 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
WO2010089706A1 (fr) | 2009-02-04 | 2010-08-12 | Ecole Polytechnique Federale De Lausanne (Epfl) | Utilisation de igf-1 et de nt-3 dans le traitement d'une adrénoleucodystrophie à liaison x |
BR112012000865A2 (pt) | 2009-07-17 | 2019-09-24 | T Tabor Aaron | "composição e método para a modificação genética cosmética de células substancialmente intactas" |
JP5571186B2 (ja) * | 2009-07-22 | 2014-08-13 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | 59位にアミノ酸置換を有するインスリン様増殖因子−1(igf−1)の類似体 |
US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
US10821155B2 (en) * | 2018-06-27 | 2020-11-03 | Juvena Therapeutics, Inc. | Heparin-associated polypeptides and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4366246A (en) * | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
US4356270A (en) * | 1977-11-08 | 1982-10-26 | Genentech, Inc. | Recombinant DNA cloning vehicle |
IE52122B1 (en) * | 1980-08-25 | 1987-06-24 | Univ California | Somatostatin or somatostatin precursors |
US4414150A (en) * | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
EP0068375A3 (fr) * | 1981-06-22 | 1983-04-13 | G.D. Searle & Co. | Techniques d'ADN recombinant pour la production de relaxine |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
ATE95236T1 (de) * | 1983-04-25 | 1993-10-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren. |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
SE8303626D0 (sv) * | 1983-06-23 | 1983-06-23 | Kabigen Ab | A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced |
NL8302324A (nl) * | 1983-06-30 | 1985-01-16 | Rijksuniversiteit Utrecht De | Escherichia coli stam, een voor deze stam karakteristiek plasmide, een werkwijze ter bereiding van dit plasmide, een precursor van een somatomedine, alsmede een groeibevorderend preparaat. |
US4710473A (en) * | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
-
1984
- 1984-08-01 WO PCT/US1984/001218 patent/WO1985000831A1/fr unknown
- 1984-08-03 EP EP90115259A patent/EP0406913A1/fr not_active Withdrawn
- 1984-08-03 EP EP84109218A patent/EP0135094A1/fr not_active Withdrawn
- 1984-08-10 IL IL72645A patent/IL72645A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0406913A1 (fr) | 1991-01-09 |
EP0135094A1 (fr) | 1985-03-27 |
WO1985000831A1 (fr) | 1985-02-28 |
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