IL71744A - Pharmaceutical parenteral formulation of nimodipine and its preparation - Google Patents

Pharmaceutical parenteral formulation of nimodipine and its preparation

Info

Publication number
IL71744A
IL71744A IL71744A IL7174484A IL71744A IL 71744 A IL71744 A IL 71744A IL 71744 A IL71744 A IL 71744A IL 7174484 A IL7174484 A IL 7174484A IL 71744 A IL71744 A IL 71744A
Authority
IL
Israel
Prior art keywords
weight
nimodipine
per cent
parenteral formulation
preparation
Prior art date
Application number
IL71744A
Other languages
English (en)
Other versions
IL71744A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL71744A0 publication Critical patent/IL71744A0/xx
Publication of IL71744A publication Critical patent/IL71744A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
IL71744A 1983-05-06 1984-05-03 Pharmaceutical parenteral formulation of nimodipine and its preparation IL71744A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833316510 DE3316510A1 (de) 1983-05-06 1983-05-06 Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen

Publications (2)

Publication Number Publication Date
IL71744A0 IL71744A0 (en) 1984-09-30
IL71744A true IL71744A (en) 1988-04-29

Family

ID=6198265

Family Applications (1)

Application Number Title Priority Date Filing Date
IL71744A IL71744A (en) 1983-05-06 1984-05-03 Pharmaceutical parenteral formulation of nimodipine and its preparation

Country Status (19)

Country Link
US (1) US5114956A (el)
EP (1) EP0126315B1 (el)
JP (1) JPS59206305A (el)
KR (1) KR920000306B1 (el)
AT (1) ATE24835T1 (el)
AU (1) AU562293B2 (el)
BE (1) BE899564A (el)
CA (1) CA1220424A (el)
DE (2) DE3316510A1 (el)
DK (1) DK164148C (el)
ES (1) ES531995A0 (el)
FR (1) FR2545354B1 (el)
GR (1) GR81609B (el)
HK (1) HK75889A (el)
IL (1) IL71744A (el)
IT (1) IT1181804B (el)
PT (1) PT78542B (el)
SG (1) SG44489G (el)
ZA (1) ZA843352B (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246313A (ja) * 1984-05-22 1985-12-06 Yamanouchi Pharmaceut Co Ltd 塩酸ニカルジピンの注射剤およびその製法
FR2585574B1 (fr) * 1985-07-31 1988-09-09 Corbiere Jerome Nouvelles compositions pharmaceutiques anti-glaucomateuses a base de 1,4-dihydropyridines et leur procede d'obtention
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
AT387518B (de) * 1985-12-18 1989-02-10 Bayer Ag Verfahren zur herstellung von fluessigen spruehpraeparaten von dihydropyridinen
DE3702105A1 (de) * 1987-01-24 1988-08-04 Bayer Ag Parenterale loesung
CA2011063C (en) * 1989-02-28 1999-07-06 Calum B. Macfarlane Nicardipine pharmaceutical composition for parenteral administration
RU1804845C (ru) * 1991-02-15 1993-03-30 Институт Органического Синтеза Латвийской Ан Ноотропное вещество
EP1609477B1 (en) * 1994-12-12 2011-11-09 Omeros Corporation Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
KR100517210B1 (ko) * 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
JPH10510540A (ja) * 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
US8034762B2 (en) * 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
CA2625862A1 (en) * 2005-10-14 2007-04-26 Transform Pharmaceuticals, Inc. Liquid pharmaceutical compositions of nimodipine
WO2007125028A1 (de) * 2006-04-28 2007-11-08 Basf Se Verfahren zur solubilisierung von hydrophoben wirkstoffen in wässrigem medium
US8728504B2 (en) 2010-02-05 2014-05-20 Basf Se Process for solubilizing hydrophobic active ingredients in aqueous medium
WO2011095449A1 (de) 2010-02-05 2011-08-11 Basf Se Verfahren zur solubilisierung von hydrophoben wirkstoffen in wässrigem medium
DK3238709T3 (da) 2011-04-28 2020-09-28 Platform Brightworks Two Ltd Forbedrede parenterale formuleringer af lipofile farmaceutiske midler og fremgangsmåder til fremstilling og anvendelse af samme
US10092553B2 (en) 2016-04-13 2018-10-09 Nortic Holdings Inc. Stable nimodipine parenteral formulation
WO2017180718A1 (en) * 2016-04-13 2017-10-19 Grace Therapeutics Llc Stable nimopidine parenteral formulation
EP3755326A4 (en) 2018-02-22 2021-11-03 Nortic Holdings Inc. STABLE PARENTERAL NIMOPIDIN FORMULATION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DK224184A (da) 1984-11-07
DK164148B (da) 1992-05-18
CA1220424A (en) 1987-04-14
SG44489G (en) 1989-11-17
EP0126315A1 (de) 1984-11-28
JPH0422888B2 (el) 1992-04-20
KR840009031A (ko) 1984-12-24
JPS59206305A (ja) 1984-11-22
IL71744A0 (en) 1984-09-30
PT78542A (en) 1984-06-01
ES8505542A1 (es) 1985-06-01
FR2545354B1 (fr) 1986-09-26
GR81609B (el) 1984-12-11
DE3316510A1 (de) 1984-11-08
FR2545354A1 (fr) 1984-11-09
ES531995A0 (es) 1985-06-01
IT8448139A0 (it) 1984-05-04
PT78542B (en) 1986-07-14
ZA843352B (en) 1984-12-24
AU562293B2 (en) 1987-06-04
KR920000306B1 (ko) 1992-01-11
DK224184D0 (da) 1984-05-04
BE899564A (fr) 1984-11-05
DE3461988D1 (en) 1987-02-19
US5114956A (en) 1992-05-19
ATE24835T1 (de) 1987-01-15
HK75889A (en) 1989-09-29
DK164148C (da) 1992-10-26
EP0126315B1 (de) 1987-01-14
IT1181804B (it) 1987-09-30
AU2758384A (en) 1984-11-08

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Legal Events

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