IL70539A - 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)-quinoline-3-carboxylic acids and their derivatives,their preparation and antibacterial agents containing them - Google Patents

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)-quinoline-3-carboxylic acids and their derivatives,their preparation and antibacterial agents containing them

Info

Publication number
IL70539A
IL70539A IL70539A IL7053983A IL70539A IL 70539 A IL70539 A IL 70539A IL 70539 A IL70539 A IL 70539A IL 7053983 A IL7053983 A IL 7053983A IL 70539 A IL70539 A IL 70539A
Authority
IL
Israel
Prior art keywords
piperazinyl
cyclopropyl
dihydro
oxo
fluoro
Prior art date
Application number
IL70539A
Other languages
English (en)
Other versions
IL70539A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6182078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL70539(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL70539A0 publication Critical patent/IL70539A0/xx
Publication of IL70539A publication Critical patent/IL70539A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL70539A 1982-12-29 1983-12-26 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)-quinoline-3-carboxylic acids and their derivatives,their preparation and antibacterial agents containing them IL70539A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823248506 DE3248506A1 (de) 1982-12-29 1982-12-29 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
IL70539A0 IL70539A0 (en) 1984-03-30
IL70539A true IL70539A (en) 1987-08-31

Family

ID=6182078

Family Applications (1)

Application Number Title Priority Date Filing Date
IL70539A IL70539A (en) 1982-12-29 1983-12-26 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)-quinoline-3-carboxylic acids and their derivatives,their preparation and antibacterial agents containing them

Country Status (20)

Country Link
US (1) US4544658A (fr)
EP (1) EP0113093B1 (fr)
JP (1) JPS59130880A (fr)
KR (2) KR870000901B1 (fr)
AT (1) ATE19877T1 (fr)
AU (1) AU560153B2 (fr)
CA (1) CA1218070A (fr)
DD (1) DD216016A5 (fr)
DE (2) DE3248506A1 (fr)
DK (1) DK160989C (fr)
ES (1) ES528495A0 (fr)
FI (1) FI79102C (fr)
GR (1) GR79445B (fr)
HU (1) HU191392B (fr)
IE (1) IE56460B1 (fr)
IL (1) IL70539A (fr)
NO (1) NO162236C (fr)
NZ (1) NZ206705A (fr)
PH (3) PH20545A (fr)
ZA (1) ZA839646B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420770A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3426483A1 (de) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von halogenierten chinoloncarbonsaeuren
DE3435392A1 (de) * 1984-09-27 1986-04-03 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoesaeure
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones
EP0191185B1 (fr) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Dérivés de l'acide quinoléine-carboxylique
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU594983B2 (en) 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3617803A1 (de) * 1985-11-07 1987-11-19 Bayer Ag Verwendung von gyrasehemmern zur dekontamination von mycoplasma-infizierten zellkulturen
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US4940710A (en) * 1986-01-17 1990-07-10 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
MX9700497A (es) * 1994-07-18 1997-04-30 Ube Industries Derivado de acido trifluorometilquinolinocarboxilico.
JP3449658B2 (ja) * 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
JP4669607B2 (ja) 1997-09-15 2011-04-13 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン類、その組成物およびその使用
KR100821894B1 (ko) * 2004-07-02 2008-04-16 주식회사 코오롱 항균 염료 및 그를 이용한 항균 섬유
WO2007110835A2 (fr) * 2006-03-28 2007-10-04 The Procter & Gamble Company Procede de couplage pour preparer des intermediaires quinolone
CA2647457C (fr) * 2006-03-28 2011-05-24 The Procter & Gamble Company Procede de reduction par un hydrure servant a preparer des intermediaires de quinolones
DK2001862T3 (da) * 2006-03-28 2011-08-08 Warner Chilcott Co Llc Malatsalte og polymorfe af (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyklopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolincarboxylsyre

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
GR79445B (fr) 1984-10-30
ATE19877T1 (de) 1986-06-15
CA1218070A (fr) 1987-02-17
ES8406846A1 (es) 1984-09-01
EP0113093B1 (fr) 1986-05-21
DK604083D0 (da) 1983-12-28
DE3363608D1 (en) 1986-06-26
FI79102C (fi) 1989-11-10
FI834806A (fi) 1984-06-30
PH20545A (en) 1987-02-09
NZ206705A (en) 1986-01-24
AU560153B2 (en) 1987-04-02
KR840006990A (ko) 1984-12-04
ES528495A0 (es) 1984-09-01
DD216016A5 (de) 1984-11-28
DE3248506A1 (de) 1984-07-05
FI834806A0 (fi) 1983-12-27
IE56460B1 (en) 1991-08-14
JPS59130880A (ja) 1984-07-27
NO162236B (no) 1989-08-21
HU191392B (en) 1987-02-27
US4544658A (en) 1985-10-01
KR870000901B1 (ko) 1987-05-04
FI79102B (fi) 1989-07-31
KR870001003B1 (ko) 1987-05-18
ZA839646B (en) 1984-08-29
IE833034L (en) 1984-06-29
EP0113093A1 (fr) 1984-07-11
PH21478A (en) 1987-10-28
JPH0323549B2 (fr) 1991-03-29
PH22453A (en) 1988-09-12
DK604083A (da) 1984-06-30
IL70539A0 (en) 1984-03-30
NO834632L (no) 1984-07-02
DK160989B (da) 1991-05-13
DK160989C (da) 1991-10-28
AU2251083A (en) 1984-07-05
NO162236C (no) 1989-11-29

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ES484578A1 (es) Procedimiento para la obtencion de derivados de carboxi-qui-nolinas sustituidos
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Legal Events

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