IL70519A0 - Cephalosporin derivatives and a process for their preparation - Google Patents
Cephalosporin derivatives and a process for their preparationInfo
- Publication number
- IL70519A0 IL70519A0 IL70519A IL7051983A IL70519A0 IL 70519 A0 IL70519 A0 IL 70519A0 IL 70519 A IL70519 A IL 70519A IL 7051983 A IL7051983 A IL 7051983A IL 70519 A0 IL70519 A0 IL 70519A0
- Authority
- IL
- Israel
- Prior art keywords
- denotes
- general formula
- group
- acid addition
- see diagramm
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001782 cephems Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 abstract 1
- 150000002537 isoquinolines Chemical class 0.000 abstract 1
- 150000003248 quinolines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Rigid Pipes And Flexible Pipes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823247614 DE3247614A1 (de) | 1982-12-23 | 1982-12-23 | Cephalosporinderivate und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL70519A0 true IL70519A0 (en) | 1984-03-30 |
Family
ID=6181485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL70519A IL70519A0 (en) | 1982-12-23 | 1983-12-21 | Cephalosporin derivatives and a process for their preparation |
Country Status (19)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK500285A (da) * | 1984-11-02 | 1986-05-03 | Glaxo Group Ltd | Cephalosporinantibiotika |
| CA1267647A (en) * | 1984-12-27 | 1990-04-10 | Ryosuke Ushijima | Cephalosporin derivatives |
| NO166283C (no) * | 1985-03-01 | 1991-06-26 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater. |
| GB2183630A (en) * | 1985-10-31 | 1987-06-10 | Glaxo Group Ltd | Cephalosporin antibiotics |
| EP0238060B1 (en) * | 1986-03-19 | 1992-01-08 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, processes for their preparation and antibacterial agents |
| JPH0645631B2 (ja) * | 1986-03-19 | 1994-06-15 | 萬有製薬株式会社 | 新規セフアロスポリン誘導体 |
| US4814328A (en) * | 1986-03-19 | 1989-03-21 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, and antibacterial agents |
| WO1988005776A1 (en) * | 1987-02-02 | 1988-08-11 | Teijin Limited | Cephalosporin compounds or their salts, process for their preparation, and parmaceutical compositions |
| AU1228988A (en) * | 1987-02-03 | 1988-08-24 | Teijin Limited | Cephalosporin compounds or their salts, process for their preparation, and pharmaceutical compositions |
| DE3910421A1 (de) * | 1989-03-31 | 1990-10-04 | Hoechst Ag | Polare cephalosporinderivate und verfahren zu ihrer herstellung |
| TW200305422A (en) | 2002-03-18 | 2003-11-01 | Shionogi & Co | Broad spectrum cefem compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2715385A1 (de) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| US4396619A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
| US4396620A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin quinolinium betaines |
| US4450270A (en) * | 1981-10-02 | 1984-05-22 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
| US4402955A (en) * | 1981-10-02 | 1983-09-06 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
-
1982
- 1982-12-23 DE DE19823247614 patent/DE3247614A1/de not_active Withdrawn
-
1983
- 1983-12-19 HU HU834332A patent/HU189792B/hu unknown
- 1983-12-21 KR KR1019830006058A patent/KR840007015A/ko not_active Withdrawn
- 1983-12-21 PH PH30016A patent/PH20088A/en unknown
- 1983-12-21 AT AT83112860T patent/ATE37881T1/de not_active IP Right Cessation
- 1983-12-21 NZ NZ206659A patent/NZ206659A/en unknown
- 1983-12-21 EP EP83112860A patent/EP0111935B1/de not_active Expired
- 1983-12-21 DD DD83258350A patent/DD216026A5/de unknown
- 1983-12-21 DE DE8383112860T patent/DE3378212D1/de not_active Expired
- 1983-12-21 IL IL70519A patent/IL70519A0/xx unknown
- 1983-12-21 ES ES528247A patent/ES528247A0/es active Granted
- 1983-12-21 FI FI834710A patent/FI834710A7/fi not_active Application Discontinuation
- 1983-12-21 GR GR73316A patent/GR81360B/el unknown
- 1983-12-22 DK DK594383A patent/DK594383A/da not_active Application Discontinuation
- 1983-12-22 PT PT77877A patent/PT77877B/pt unknown
- 1983-12-22 JP JP58243058A patent/JPS59130294A/ja active Pending
- 1983-12-22 ZA ZA839526A patent/ZA839526B/xx unknown
- 1983-12-22 AU AU22809/83A patent/AU2280983A/en not_active Abandoned
- 1983-12-22 CS CS839807A patent/CS249132B2/cs unknown
- 1983-12-22 NO NO834775A patent/NO834775L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3378212D1 (en) | 1988-11-17 |
| ES8406494A1 (es) | 1984-08-01 |
| GR81360B (enrdf_load_html_response) | 1984-12-11 |
| NO834775L (no) | 1984-06-25 |
| EP0111935B1 (de) | 1988-10-12 |
| AU2280983A (en) | 1984-06-28 |
| DE3247614A1 (de) | 1984-07-05 |
| PT77877A (de) | 1984-01-01 |
| HU189792B (en) | 1986-07-28 |
| DK594383A (da) | 1984-06-24 |
| ATE37881T1 (de) | 1988-10-15 |
| PH20088A (en) | 1986-09-24 |
| FI834710A7 (fi) | 1984-06-24 |
| JPS59130294A (ja) | 1984-07-26 |
| CS249132B2 (en) | 1987-03-12 |
| HUT34036A (en) | 1985-01-28 |
| PT77877B (de) | 1986-04-21 |
| ES528247A0 (es) | 1984-08-01 |
| KR840007015A (ko) | 1984-12-04 |
| DD216026A5 (de) | 1984-11-28 |
| DK594383D0 (da) | 1983-12-22 |
| ZA839526B (en) | 1984-08-29 |
| EP0111935A2 (de) | 1984-06-27 |
| NZ206659A (en) | 1986-11-12 |
| EP0111935A3 (en) | 1985-07-03 |
| FI834710A0 (fi) | 1983-12-21 |
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