PH20088A - Cephalosporin derivatives,composition containing same and method of use thereof - Google Patents
Cephalosporin derivatives,composition containing same and method of use thereofInfo
- Publication number
- PH20088A PH20088A PH30016A PH30016A PH20088A PH 20088 A PH20088 A PH 20088A PH 30016 A PH30016 A PH 30016A PH 30016 A PH30016 A PH 30016A PH 20088 A PH20088 A PH 20088A
- Authority
- PH
- Philippines
- Prior art keywords
- denotes
- general formula
- group
- acid addition
- see diagramm
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001782 cephems Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 abstract 1
- 150000002537 isoquinolines Chemical class 0.000 abstract 1
- 150000003248 quinolines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Rigid Pipes And Flexible Pipes (AREA)
Abstract
For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. Cephem derivatives of the general formula see diagramm : EP0111935,P10,F1 and physiologically acceptable acid addition salts thereof in which R**1 denotes hydrogen, R**2 denotes hydrogen, R**3 denotes C1 -C4 -alkyl optionally substituted by fluorine, A denotes a quinolinium or an isoquinolinium radical, each of which can also be substituted once or twice by C1 -C4 -alkyl and in which the R**3O group is in the syn position. For the Contracting State : AT A process for the preparation of cephem derivatives of the general formula I see diagramm : EP0111935,P11,F1 and physiologically acceptable acid addition salts thereof in which R**1 denotes hydrogen, R**2 denotes hydrogen, R**3 denotes C1 -C4 -alkyl optionally substituted by fluorine, A denotes a quinolinium or an isoquinolinium radical, each of which can also be substituted once or twice by C1 -C4 -alkyl and in which the R**3O group is in the syn position, which comprises a) reacting a compound of the general formula II see diagramm : EP0111935,P11,F2 or salts thereof or a reactive derivative of the compound II in which R**1, R**2 and R**3 have the abovementioned meaning and R**8 denotes an amino group or a protected amino group and R**9 denotes a group which can be replaced by quinoline, isoquinoline or substituted quinolines or isoquinolines corresponding to the radicals A of the formula I, with quinoline, isoquinoline or one of their derivatives, and alpha) splitting off a protective group which is present where appropriate and beta) if necessary, converting the resulting product into a physiologically acceptable acid addition salt, or b) reacting a 7-aminocephen compound of the general formula III see diagramm : EP0111935,P12,F3 or acid addition salts thereof in which R**2 and A have the abovementioned meaning, it also being possible for the amino group to be present in the form of a reactive derivative, with a 2-(2-aminothiazol-4-yl)-2-syn-oximinoacetic acid of the general formula IV see diagramm : EP0111935,P12,F4 in which R**1, R**3 and R**8 have the above meaning, or with an activated derivative of this compound, and alpha) splitting off a protective group which is present where appropriate and beta) if necessary, converting the resulting product into a physiologically acceptable acid addition salt
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823247614 DE3247614A1 (en) | 1982-12-23 | 1982-12-23 | CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH20088A true PH20088A (en) | 1986-09-24 |
Family
ID=6181485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH30016A PH20088A (en) | 1982-12-23 | 1983-12-21 | Cephalosporin derivatives,composition containing same and method of use thereof |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0111935B1 (en) |
| JP (1) | JPS59130294A (en) |
| KR (1) | KR840007015A (en) |
| AT (1) | ATE37881T1 (en) |
| AU (1) | AU2280983A (en) |
| CS (1) | CS249132B2 (en) |
| DD (1) | DD216026A5 (en) |
| DE (2) | DE3247614A1 (en) |
| DK (1) | DK594383A (en) |
| ES (1) | ES528247A0 (en) |
| FI (1) | FI834710A7 (en) |
| GR (1) | GR81360B (en) |
| HU (1) | HU189792B (en) |
| IL (1) | IL70519A0 (en) |
| NO (1) | NO834775L (en) |
| NZ (1) | NZ206659A (en) |
| PH (1) | PH20088A (en) |
| PT (1) | PT77877B (en) |
| ZA (1) | ZA839526B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK500285A (en) * | 1984-11-02 | 1986-05-03 | Glaxo Group Ltd | cephalosporin antibiotics |
| DE3587997D1 (en) * | 1984-12-27 | 1995-04-06 | Banyu Pharma Co Ltd | Isoindoline derivatives. |
| EP0203271B1 (en) * | 1985-03-01 | 1993-05-26 | Takeda Chemical Industries, Ltd. | Antibacterial compounds, their production and use |
| GB2183630A (en) * | 1985-10-31 | 1987-06-10 | Glaxo Group Ltd | Cephalosporin antibiotics |
| JPH0645631B2 (en) * | 1986-03-19 | 1994-06-15 | 萬有製薬株式会社 | New cefalosporin derivative |
| US4814328A (en) * | 1986-03-19 | 1989-03-21 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, and antibacterial agents |
| EP0238060B1 (en) * | 1986-03-19 | 1992-01-08 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, processes for their preparation and antibacterial agents |
| EP0373216A4 (en) * | 1987-02-02 | 1992-08-12 | Teijin Limited | Cephalosporin compounds or their salts, process for their preparation, and parmaceutical compositions |
| EP0347459A4 (en) * | 1987-02-03 | 1990-04-10 | Teijin Ltd | Cephalosporin compounds or their salts, process for their preparation, and pharmaceutical compositions. |
| DE3910421A1 (en) * | 1989-03-31 | 1990-10-04 | Hoechst Ag | POLAR CEPHALOSPORINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| TW200305422A (en) | 2002-03-18 | 2003-11-01 | Shionogi & Co | Broad spectrum cefem compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2715385A1 (en) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
| DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
| US4396620A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin quinolinium betaines |
| US4396619A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
| US4402955A (en) * | 1981-10-02 | 1983-09-06 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
| US4450270A (en) * | 1981-10-02 | 1984-05-22 | Eli Lilly And Company | Dioximino cephalosporin antibiotics |
-
1982
- 1982-12-23 DE DE19823247614 patent/DE3247614A1/en not_active Withdrawn
-
1983
- 1983-12-19 HU HU834332A patent/HU189792B/en unknown
- 1983-12-21 DE DE8383112860T patent/DE3378212D1/en not_active Expired
- 1983-12-21 GR GR73316A patent/GR81360B/el unknown
- 1983-12-21 EP EP83112860A patent/EP0111935B1/en not_active Expired
- 1983-12-21 KR KR1019830006058A patent/KR840007015A/en not_active Withdrawn
- 1983-12-21 IL IL70519A patent/IL70519A0/en unknown
- 1983-12-21 DD DD83258350A patent/DD216026A5/en unknown
- 1983-12-21 NZ NZ206659A patent/NZ206659A/en unknown
- 1983-12-21 AT AT83112860T patent/ATE37881T1/en not_active IP Right Cessation
- 1983-12-21 PH PH30016A patent/PH20088A/en unknown
- 1983-12-21 ES ES528247A patent/ES528247A0/en active Granted
- 1983-12-21 FI FI834710A patent/FI834710A7/en not_active Application Discontinuation
- 1983-12-22 DK DK594383A patent/DK594383A/en not_active Application Discontinuation
- 1983-12-22 CS CS839807A patent/CS249132B2/en unknown
- 1983-12-22 AU AU22809/83A patent/AU2280983A/en not_active Abandoned
- 1983-12-22 ZA ZA839526A patent/ZA839526B/en unknown
- 1983-12-22 NO NO834775A patent/NO834775L/en unknown
- 1983-12-22 PT PT77877A patent/PT77877B/en unknown
- 1983-12-22 JP JP58243058A patent/JPS59130294A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES8406494A1 (en) | 1984-08-01 |
| DK594383D0 (en) | 1983-12-22 |
| ZA839526B (en) | 1984-08-29 |
| DE3247614A1 (en) | 1984-07-05 |
| JPS59130294A (en) | 1984-07-26 |
| ES528247A0 (en) | 1984-08-01 |
| HU189792B (en) | 1986-07-28 |
| DE3378212D1 (en) | 1988-11-17 |
| NZ206659A (en) | 1986-11-12 |
| FI834710A0 (en) | 1983-12-21 |
| CS249132B2 (en) | 1987-03-12 |
| DD216026A5 (en) | 1984-11-28 |
| HUT34036A (en) | 1985-01-28 |
| PT77877A (en) | 1984-01-01 |
| AU2280983A (en) | 1984-06-28 |
| EP0111935B1 (en) | 1988-10-12 |
| FI834710A7 (en) | 1984-06-24 |
| NO834775L (en) | 1984-06-25 |
| ATE37881T1 (en) | 1988-10-15 |
| PT77877B (en) | 1986-04-21 |
| IL70519A0 (en) | 1984-03-30 |
| KR840007015A (en) | 1984-12-04 |
| EP0111935A2 (en) | 1984-06-27 |
| DK594383A (en) | 1984-06-24 |
| EP0111935A3 (en) | 1985-07-03 |
| GR81360B (en) | 1984-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE802347L (en) | 7-acylamino-3-vinylcephalosporanic acid derivatives | |
| DE3273892D1 (en) | 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing them | |
| DE3279103D1 (en) | New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them | |
| PH20088A (en) | Cephalosporin derivatives,composition containing same and method of use thereof | |
| PH21007A (en) | Quinoline carboxylic acid derivatives and a process for the preparation thereof | |
| PH21026A (en) | Cephalosporin derivatives, its pharmaceutical formulation and method of use thereof | |
| DE3474148D1 (en) | Cephalosporin derivatives and process for their preparation | |
| DE3071497D1 (en) | 2-penem compounds; a method for their preparation and pharmaceutical compositions comprising them |