IL68964A - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments

Info

Publication number
IL68964A
IL68964A IL68964A IL6896483A IL68964A IL 68964 A IL68964 A IL 68964A IL 68964 A IL68964 A IL 68964A IL 6896483 A IL6896483 A IL 6896483A IL 68964 A IL68964 A IL 68964A
Authority
IL
Israel
Prior art keywords
sub
hydrogen
lower alkyl
same
benzazepines
Prior art date
Application number
IL68964A
Other languages
English (en)
Other versions
IL68964A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL68964A0 publication Critical patent/IL68964A0/xx
Publication of IL68964A publication Critical patent/IL68964A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL68964A 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments IL68964A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof

Publications (2)

Publication Number Publication Date
IL68964A0 IL68964A0 (en) 1983-10-31
IL68964A true IL68964A (en) 1988-03-31

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
IL68964A IL68964A (en) 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines,a process for preparing the same and their use as medicaments

Country Status (17)

Country Link
US (1) US4988690A (ko)
EP (1) EP0096838B1 (ko)
JP (1) JPS595165A (ko)
KR (1) KR900001214B1 (ko)
AT (1) ATE26263T1 (ko)
AU (1) AU570920B2 (ko)
CA (1) CA1214460A (ko)
DE (1) DE3370621D1 (ko)
DK (1) DK270983A (ko)
ES (1) ES8503666A1 (ko)
FI (1) FI78473C (ko)
GR (1) GR78291B (ko)
HU (1) HU190902B (ko)
IE (1) IE55404B1 (ko)
IL (1) IL68964A (ko)
PT (1) PT76864B (ko)
ZA (1) ZA834309B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27337A (en) * 1987-03-27 1993-06-08 Schering Corp Substituted benzazepines their preparation and pharmaceutical compositions containing them
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA885824B (en) * 1987-08-14 1989-04-26 Merrell Dow Pharma Novel antidepressants
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
US7115766B2 (en) * 2000-11-30 2006-10-03 Indiana University Research & Technology Corp. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
WO2005003096A1 (en) * 2003-06-17 2005-01-13 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
ES2571220T3 (es) 2003-06-17 2016-05-24 Arena Pharm Inc Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
US8168624B2 (en) 2004-12-21 2012-05-01 Arena Pharmaceuticals, Inc. Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
CN102627607A (zh) * 2004-12-23 2012-08-08 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
CA2646044A1 (en) 2006-04-03 2007-10-25 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
SG177128A1 (en) * 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
BRPI0811200A8 (pt) 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidrobenzapinas arilóxi- e heteroarilóxi-substituídas e uso das mesmas para bloquear percepção de norepinefrina, dopamina, e serotonina
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
MX2013002418A (es) 2010-09-01 2013-08-01 Arena Pharm Inc Administracion de lorcaserina a individuos con daño renal.
WO2012030957A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
US4988690A (en) 1991-01-29
DK270983A (da) 1983-12-15
AU1576483A (en) 1983-12-22
ES523191A0 (es) 1985-03-01
FI78473B (fi) 1989-04-28
GR78291B (ko) 1984-09-26
FI78473C (fi) 1989-08-10
HU190902B (en) 1986-12-28
EP0096838A1 (en) 1983-12-28
IE55404B1 (en) 1990-09-12
EP0096838B1 (en) 1987-04-01
KR900001214B1 (ko) 1990-02-28
ES8503666A1 (es) 1985-03-01
IE831384L (en) 1983-12-14
FI832092A0 (fi) 1983-06-10
PT76864A (en) 1983-07-01
IL68964A0 (en) 1983-10-31
JPS595165A (ja) 1984-01-12
DK270983D0 (da) 1983-06-13
AU570920B2 (en) 1988-03-31
PT76864B (en) 1986-02-27
ATE26263T1 (de) 1987-04-15
CA1214460A (en) 1986-11-25
ZA834309B (en) 1984-03-28
JPH0365342B2 (ko) 1991-10-11
DE3370621D1 (en) 1987-05-07
FI832092L (fi) 1983-12-15
KR840005103A (ko) 1984-11-03

Similar Documents

Publication Publication Date Title
DE3370621D1 (en) 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments
MY109937A (en) Substituted azoles, processes for the preparation thereof, agents containing these, and the use thereof.
EP0163599A3 (en) Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
ES8506677A1 (es) Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina.
CA1262357A (en) N-HYDROXYL PROTECTIVE GROUPS AND METHOD FOR THE PREPARATION OF 3-ACYLAMINO-1-HYDROXY-2-AZETIDINONES
PT82854A (en) Process for the preparation of pyridonocarboxylic acid derivatives
MY100095A (en) 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
ES8401961A1 (es) Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas.
HUT43570A (en) Process for preparing novel decahydroquinoline derivatives and their salts, as well as pharmaceutics comprising the derivatives
HUT40101A (en) Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
ES8601201A1 (es) Procedimiento para preparar derivados de imidazolina
YU217181A (en) Process for preparing 2-(1,4-benzodioxane-2-ylalkyl)-imidazoles
ES8308543A1 (es) "procedimiento para la preparacion de nuevas 2-fenil-2-(piridiloxi)-etilaminas sustituidas".
ES8502122A1 (es) Procedimiento para la preparacion de nuevos compuestos carboxamidicos de pirrol ortocondensado.
DE3160909D1 (en) 5,6,8,9-tetrahydro-7h-dibenz(d,f)azonine derivatives, the production thereof and compositions containing them
HUT43568A (en) Process for preparing novel 2-pyridiyl-acetic acid derivatives and pharmaceutics comprising the same
EP0103357A3 (en) Substituted phenylpiperazine compounds suitable as antihypertensive agents, and processes for their production
ES8405020A1 (es) Un procedimiento para la preparacion de derivados de fosfolipidos.
HUT34185A (en) Process for preparing isoquinoline derivatives
ES8703457A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiacetona.
ZA862348B (en) Diamine derivatives
JPS5636414A (en) Anticonvulsant agent containing omega-aminoalkoxystilbene or its acid addition salt as active constituent
MY101746A (en) 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.
ES472897A1 (es) Metodo de preparar derivados de antraquinona
KR840002374A (ko) 디옥산 진통제의 합성방법