IL68497A0 - Benzoazacycloalkyl-spiro-imidazolidines,their preparation and pharmaceutical compositions containing them - Google Patents
Benzoazacycloalkyl-spiro-imidazolidines,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL68497A0 IL68497A0 IL68497A IL6849783A IL68497A0 IL 68497 A0 IL68497 A0 IL 68497A0 IL 68497 A IL68497 A IL 68497A IL 6849783 A IL6849783 A IL 6849783A IL 68497 A0 IL68497 A0 IL 68497A0
- Authority
- IL
- Israel
- Prior art keywords
- benzoazacycloalkyl
- imidazolidines
- spiro
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL68497A0 true IL68497A0 (en) | 1983-07-31 |
Family
ID=9273425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL68497A IL68497A0 (en) | 1982-04-27 | 1983-04-26 | Benzoazacycloalkyl-spiro-imidazolidines,their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5910584A (enExample) |
| KR (1) | KR840004428A (enExample) |
| AT (1) | ATA125383A (enExample) |
| AU (1) | AU1395383A (enExample) |
| BE (1) | BE896572A (enExample) |
| DD (1) | DD209833A5 (enExample) |
| DE (1) | DE3315106A1 (enExample) |
| DK (1) | DK183583A (enExample) |
| ES (1) | ES8405796A1 (enExample) |
| FR (1) | FR2525603A1 (enExample) |
| GB (1) | GB2133401B (enExample) |
| GR (1) | GR78481B (enExample) |
| IL (1) | IL68497A0 (enExample) |
| IT (1) | IT1167123B (enExample) |
| LU (1) | LU84770A1 (enExample) |
| MA (1) | MA19783A1 (enExample) |
| NL (1) | NL8301476A (enExample) |
| NO (1) | NO831473L (enExample) |
| OA (1) | OA07412A (enExample) |
| PT (1) | PT76595B (enExample) |
| SE (1) | SE8302347L (enExample) |
| ZA (1) | ZA832927B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| BRPI0411470A (pt) | 2003-06-17 | 2006-07-11 | Arena Pharm Inc | derivados de benzazepina úteis para o tratamento de doenças associadas com o receptor de 5ht2c |
| US8367657B2 (en) | 2003-06-17 | 2013-02-05 | Arena Pharmaceuticals, Inc. | Processes for preparing 3-benzazepines |
| ME01090B (me) | 2004-12-21 | 2012-12-20 | Arena Pharm Inc | Kristalni oblici (r)-8-hloro-metil-2,3,4,5-tetrahidr0-1h-3-benzazepin hlorhidrat |
| PT1833473E (pt) | 2004-12-23 | 2009-12-17 | Arena Pharm Inc | Composições de modulador de receptor 5ht2c e métodos de utilização |
| EP2518053A1 (en) | 2006-04-03 | 2012-10-31 | Arena Pharmaceuticals, Inc. | Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
| WO2008070111A2 (en) | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
| US8822727B2 (en) | 2008-03-04 | 2014-09-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| CN102648170A (zh) | 2009-06-18 | 2012-08-22 | 艾尼纳制药公司 | 制备5-ht2c受体激动剂的方法 |
| KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법 |
| CA2808912C (en) | 2010-09-01 | 2019-09-17 | Zezhi Jesse Shao | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
| WO2012030957A2 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
| JP2013540719A (ja) | 2010-09-01 | 2013-11-07 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 腎欠陥を有する個体へのロルカセリンの投与 |
| KR20130138770A (ko) | 2010-09-01 | 2013-12-19 | 아레나 파마슈티칼스, 인크. | 광학적으로 활성 산을 갖는 로르카세린의 염 |
| KR20190128001A (ko) | 2012-10-09 | 2019-11-13 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리 방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 PT PT76595A patent/PT76595B/pt unknown
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Withdrawn
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 SE SE8302347A patent/SE8302347L/xx not_active Application Discontinuation
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 OA OA57984A patent/OA07412A/xx unknown
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 ES ES521895A patent/ES8405796A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL8301476A (nl) | 1983-11-16 |
| DK183583D0 (da) | 1983-04-26 |
| FR2525603B1 (enExample) | 1984-09-14 |
| BE896572A (fr) | 1983-10-26 |
| ATA125383A (de) | 1986-05-15 |
| GR78481B (enExample) | 1984-09-27 |
| ES521895A0 (es) | 1984-06-16 |
| PT76595B (fr) | 1986-01-21 |
| SE8302347L (sv) | 1983-10-28 |
| IT8348155A0 (it) | 1983-04-26 |
| LU84770A1 (fr) | 1984-11-28 |
| DK183583A (da) | 1983-10-28 |
| OA07412A (fr) | 1984-11-30 |
| DD209833A5 (de) | 1984-05-23 |
| GB2133401B (en) | 1985-10-23 |
| NO831473L (no) | 1983-10-28 |
| MA19783A1 (fr) | 1983-12-31 |
| PT76595A (fr) | 1983-05-01 |
| SE8302347D0 (sv) | 1983-04-26 |
| ES8405796A1 (es) | 1984-06-16 |
| DE3315106A1 (de) | 1983-11-03 |
| GB2133401A (en) | 1984-07-25 |
| AU1395383A (en) | 1983-11-03 |
| JPS5910584A (ja) | 1984-01-20 |
| KR840004428A (ko) | 1984-10-15 |
| FR2525603A1 (fr) | 1983-10-28 |
| GB8311508D0 (en) | 1983-06-02 |
| ZA832927B (en) | 1984-06-27 |
| IT1167123B (it) | 1987-05-13 |
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