IL65247A - Derivatives of n-acyltetra-hydroquinoline,isoquinoline,benzazepine and benzazocine carboxylic acids,process for their preparation and pharmaceutical compositions containing them - Google Patents

Derivatives of n-acyltetra-hydroquinoline,isoquinoline,benzazepine and benzazocine carboxylic acids,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL65247A
IL65247A IL65247A IL6524782A IL65247A IL 65247 A IL65247 A IL 65247A IL 65247 A IL65247 A IL 65247A IL 6524782 A IL6524782 A IL 6524782A IL 65247 A IL65247 A IL 65247A
Authority
IL
Israel
Prior art keywords
acyltetra
benzazocine
hydroquinoline
benzazepine
isoquinoline
Prior art date
Application number
IL65247A
Other languages
English (en)
Other versions
IL65247A0 (en
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of IL65247A0 publication Critical patent/IL65247A0/xx
Publication of IL65247A publication Critical patent/IL65247A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
IL65247A 1981-03-19 1982-03-15 Derivatives of n-acyltetra-hydroquinoline,isoquinoline,benzazepine and benzazocine carboxylic acids,process for their preparation and pharmaceutical compositions containing them IL65247A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24540781A 1981-03-19 1981-03-19

Publications (2)

Publication Number Publication Date
IL65247A0 IL65247A0 (en) 1982-05-31
IL65247A true IL65247A (en) 1987-07-31

Family

ID=22926526

Family Applications (1)

Application Number Title Priority Date Filing Date
IL65247A IL65247A (en) 1981-03-19 1982-03-15 Derivatives of n-acyltetra-hydroquinoline,isoquinoline,benzazepine and benzazocine carboxylic acids,process for their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
JP (1) JPS57165355A (fr)
KR (1) KR890001146B1 (fr)
AU (1) AU558451B2 (fr)
BE (1) BE892552A (fr)
CH (1) CH658455A5 (fr)
DE (1) DE3209708A1 (fr)
DK (1) DK120982A (fr)
ES (3) ES510498A0 (fr)
FI (1) FI820974L (fr)
FR (1) FR2502149A1 (fr)
GB (1) GB2095252B (fr)
IE (1) IE53076B1 (fr)
IL (1) IL65247A (fr)
IN (1) IN156096B (fr)
IT (1) IT1150697B (fr)
NL (1) NL8201066A (fr)
NO (1) NO820903L (fr)
NZ (1) NZ200047A (fr)
PH (1) PH18657A (fr)
SE (1) SE8201654L (fr)
ZA (1) ZA821833B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3622297A1 (de) * 1986-07-03 1988-01-07 Basf Ag Disazothiophenfarbstoffe
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
ES2122941B1 (es) * 1997-05-29 1999-07-01 Esteve Quimica Sa Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
ES2289060T3 (es) 2002-01-30 2008-02-01 Les Laboratoires Servier Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis.
US7482361B2 (en) 2002-12-16 2009-01-27 Lupin Limited Crystalline form for quinapril hydrochloride and process for preparing the same
DK1603558T3 (da) * 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
IE53076B1 (en) 1988-06-08
DE3209708A1 (de) 1982-10-21
ES8307718A1 (es) 1983-08-01
GB2095252A (en) 1982-09-29
NZ200047A (en) 1985-07-12
NL8201066A (nl) 1982-10-18
NO820903L (no) 1982-09-20
ES8501363A1 (es) 1984-12-01
AU8158482A (en) 1982-09-23
CH658455A5 (de) 1986-11-14
BE892552A (fr) 1982-09-20
SE8201654L (sv) 1982-09-20
IL65247A0 (en) 1982-05-31
KR830009065A (ko) 1983-12-17
JPS57165355A (en) 1982-10-12
AU558451B2 (en) 1987-01-29
ES521030A0 (es) 1984-05-16
IT1150697B (it) 1986-12-17
IN156096B (fr) 1985-05-11
FR2502149A1 (fr) 1982-09-24
IE820635L (en) 1982-09-19
GB2095252B (en) 1985-04-17
PH18657A (en) 1985-08-29
ZA821833B (en) 1983-01-26
ES8404317A1 (es) 1984-05-16
IT8220259A0 (it) 1982-03-18
ES510498A0 (es) 1983-08-01
FR2502149B1 (fr) 1985-01-18
FI820974L (fi) 1982-09-20
KR890001146B1 (ko) 1989-04-25
ES521031A0 (es) 1984-12-01
DK120982A (da) 1982-09-20

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