IL57324A - 3-substituted-6-alkanoylamino-1,3,5-triazine-2,4-diones,process for their preparation and pharmaceutical compositions containing them - Google Patents
3-substituted-6-alkanoylamino-1,3,5-triazine-2,4-diones,process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL57324A IL57324A IL57324A IL5732479A IL57324A IL 57324 A IL57324 A IL 57324A IL 57324 A IL57324 A IL 57324A IL 5732479 A IL5732479 A IL 5732479A IL 57324 A IL57324 A IL 57324A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- radical
- pharmaceutical compositions
- phenyl
- diones
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 alkyl radical Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000166 1,3-dioxalanyl group Chemical group 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2293878 | 1978-05-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL57324A0 IL57324A0 (en) | 1979-09-30 |
| IL57324A true IL57324A (en) | 1983-10-31 |
Family
ID=10187501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL57324A IL57324A (en) | 1978-05-26 | 1979-05-17 | 3-substituted-6-alkanoylamino-1,3,5-triazine-2,4-diones,process for their preparation and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4254122A (cs) |
| EP (1) | EP0005911B1 (cs) |
| JP (1) | JPS54154779A (cs) |
| AT (1) | ATE698T1 (cs) |
| AU (1) | AU529948B2 (cs) |
| CA (1) | CA1108138A (cs) |
| CS (1) | CS213377B2 (cs) |
| DD (1) | DD143906A5 (cs) |
| DE (1) | DE2962124D1 (cs) |
| DK (1) | DK213179A (cs) |
| ES (1) | ES480932A1 (cs) |
| FI (1) | FI66180C (cs) |
| GR (1) | GR68185B (cs) |
| HU (1) | HU180252B (cs) |
| IE (1) | IE49170B1 (cs) |
| IL (1) | IL57324A (cs) |
| MW (1) | MW1379A1 (cs) |
| NO (1) | NO791722L (cs) |
| NZ (1) | NZ190402A (cs) |
| PH (1) | PH14793A (cs) |
| PT (1) | PT69650A (cs) |
| ZA (1) | ZA792247B (cs) |
| ZM (1) | ZM4579A1 (cs) |
| ZW (1) | ZW9179A1 (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8629567D0 (en) * | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| WO1998049150A1 (en) * | 1997-04-25 | 1998-11-05 | Takeda Chemical Industries, Ltd. | Triazine derivatives, their production and agrochemical composition |
| US6335339B1 (en) | 1998-01-13 | 2002-01-01 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
| US20060166872A1 (en) * | 2002-04-17 | 2006-07-27 | Jabbour Henry N | Fp receptor antagonists or pgf2 alpha antagonists for treating menorrhagia |
| US20080152640A1 (en) * | 2003-07-29 | 2008-06-26 | Peter Prehm | Means and Methods For Treating a Disease Which is Associated With an Excess Transport of Hyaluronan Across a Lipid Bilayer |
| US7199156B2 (en) * | 2003-10-10 | 2007-04-03 | Milos Chvapil | Composition and method to treat solid tumors |
| TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| MX2008014828A (es) * | 2006-05-22 | 2009-02-06 | Combinatorx Inc | Metodos y composiciones para el tratamiento de enfermedades o condiciones asociadas con niveles incrementados de proteina c-reactiva, interleucina-6 o interferon-gamma. |
| CA2737131A1 (en) * | 2007-09-19 | 2009-03-26 | Zalicus Inc. | Therapeutic regimens for the treatment of immunoinflammatory disorders |
| CA2709561A1 (en) * | 2007-12-17 | 2009-06-25 | Combinatorx, Incorporated | Therapeutic regimens for the treatment of immunoinflammatory disorders |
| SG173647A1 (en) * | 2009-02-13 | 2011-10-28 | Shionogi & Co | Novel triazine derivative and pharmaceutical composition containing same |
| WO2012020742A1 (ja) | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| US9718790B2 (en) | 2010-08-10 | 2017-08-01 | Shionogi & Co., Ltd. | Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same |
| JP6124351B2 (ja) | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| WO2022162689A1 (en) * | 2021-01-26 | 2022-08-04 | Council Of Scientific And Industrial Research | Triazine-based self-assembling system |
| TW202302541A (zh) * | 2021-03-17 | 2023-01-16 | 美商翰森生物有限責任公司 | 含氮雜環酮、其製備方法和醫藥用途 |
| CN120574183B (zh) * | 2025-07-31 | 2025-11-21 | 潍坊鑫洋化工有限公司 | 一种溴代三嗪的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983116A (en) * | 1973-04-05 | 1976-09-28 | E. I. Du Pont De Nemours And Company | Herbicidal triazines |
| US4035365A (en) * | 1973-11-01 | 1977-07-12 | Imperial Chemical Industries Limited | Triazinediones |
| GB1464248A (en) | 1973-11-01 | 1977-02-09 | Ici Ltd | Substituted triazinediones their preparation and use as herbicides |
| GB1543037A (en) * | 1975-02-05 | 1979-03-28 | Ici Ltd | Selective herbicidal triazine-diones |
| US4082536A (en) * | 1973-11-01 | 1978-04-04 | Imperial Chemical Industries Limited | Heterocyclic compounds and their use as pesticides |
| GB1504304A (en) * | 1974-02-15 | 1978-03-15 | Ici Ltd | Process of combating fungal and bacterial infections of plants with triazine dione derivatives |
| GB1599518A (en) * | 1977-02-21 | 1981-10-07 | Ici Ltd | 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof |
-
1979
- 1979-05-02 DE DE7979300756T patent/DE2962124D1/de not_active Expired
- 1979-05-02 AT AT79300756T patent/ATE698T1/de not_active IP Right Cessation
- 1979-05-02 EP EP79300756A patent/EP0005911B1/en not_active Expired
- 1979-05-07 CA CA327,103A patent/CA1108138A/en not_active Expired
- 1979-05-07 US US06/036,508 patent/US4254122A/en not_active Expired - Lifetime
- 1979-05-09 NZ NZ190402A patent/NZ190402A/xx unknown
- 1979-05-09 ZA ZA792247A patent/ZA792247B/xx unknown
- 1979-05-10 AU AU46949/79A patent/AU529948B2/en not_active Ceased
- 1979-05-15 ZW ZW91/79A patent/ZW9179A1/xx unknown
- 1979-05-17 MW MW13/79A patent/MW1379A1/xx unknown
- 1979-05-17 IL IL57324A patent/IL57324A/xx unknown
- 1979-05-19 GR GR59133A patent/GR68185B/el unknown
- 1979-05-21 PH PH22523A patent/PH14793A/en unknown
- 1979-05-22 HU HU79IE875A patent/HU180252B/hu unknown
- 1979-05-22 PT PT69650A patent/PT69650A/pt unknown
- 1979-05-23 ZM ZM45/79A patent/ZM4579A1/xx unknown
- 1979-05-23 DK DK213179A patent/DK213179A/da not_active Application Discontinuation
- 1979-05-25 DD DD79213155A patent/DD143906A5/de unknown
- 1979-05-25 FI FI791670A patent/FI66180C/fi not_active IP Right Cessation
- 1979-05-25 CS CS793623A patent/CS213377B2/cs unknown
- 1979-05-25 ES ES480932A patent/ES480932A1/es not_active Expired
- 1979-05-25 JP JP6407279A patent/JPS54154779A/ja active Pending
- 1979-05-25 NO NO791722A patent/NO791722L/no unknown
- 1979-08-08 IE IE889/79A patent/IE49170B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0005911B1 (en) | 1982-02-17 |
| IE49170B1 (en) | 1985-08-21 |
| ATE698T1 (de) | 1982-03-15 |
| ZA792247B (en) | 1980-05-28 |
| JPS54154779A (en) | 1979-12-06 |
| AU529948B2 (en) | 1983-06-30 |
| DD143906A5 (de) | 1980-09-17 |
| DK213179A (da) | 1979-11-27 |
| CS213377B2 (en) | 1982-04-09 |
| NZ190402A (en) | 1982-05-31 |
| FI791670A7 (fi) | 1979-11-27 |
| GR68185B (cs) | 1981-11-09 |
| CA1108138A (en) | 1981-09-01 |
| ES480932A1 (es) | 1980-02-01 |
| ZM4579A1 (en) | 1981-05-21 |
| ZW9179A1 (en) | 1981-01-21 |
| US4254122A (en) | 1981-03-03 |
| FI66180C (fi) | 1984-09-10 |
| IL57324A0 (en) | 1979-09-30 |
| IE790889L (en) | 1979-11-26 |
| PH14793A (en) | 1981-12-09 |
| EP0005911A1 (en) | 1979-12-12 |
| NO791722L (no) | 1979-11-27 |
| FI66180B (fi) | 1984-05-31 |
| HU180252B (en) | 1983-02-28 |
| AU4694979A (en) | 1979-11-29 |
| PT69650A (en) | 1979-06-01 |
| DE2962124D1 (en) | 1982-03-25 |
| MW1379A1 (en) | 1981-04-08 |
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