ATE698T1 - Analgetische 6-acylaminot etrahydro-1,3,5-triazin-2,4-dion-derivate, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung. - Google Patents
Analgetische 6-acylaminot etrahydro-1,3,5-triazin-2,4-dion-derivate, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung.Info
- Publication number
- ATE698T1 ATE698T1 AT79300756T AT79300756T ATE698T1 AT E698 T1 ATE698 T1 AT E698T1 AT 79300756 T AT79300756 T AT 79300756T AT 79300756 T AT79300756 T AT 79300756T AT E698 T1 ATE698 T1 AT E698T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- manufacture
- pharmaceutical compositions
- radical
- acylaminot
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 alkyl radical Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000166 1,3-dioxalanyl group Chemical group 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2293878 | 1978-05-26 | ||
| EP79300756A EP0005911B1 (en) | 1978-05-26 | 1979-05-02 | Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE698T1 true ATE698T1 (de) | 1982-03-15 |
Family
ID=10187501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79300756T ATE698T1 (de) | 1978-05-26 | 1979-05-02 | Analgetische 6-acylaminot etrahydro-1,3,5-triazin-2,4-dion-derivate, sie enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4254122A (cs) |
| EP (1) | EP0005911B1 (cs) |
| JP (1) | JPS54154779A (cs) |
| AT (1) | ATE698T1 (cs) |
| AU (1) | AU529948B2 (cs) |
| CA (1) | CA1108138A (cs) |
| CS (1) | CS213377B2 (cs) |
| DD (1) | DD143906A5 (cs) |
| DE (1) | DE2962124D1 (cs) |
| DK (1) | DK213179A (cs) |
| ES (1) | ES480932A1 (cs) |
| FI (1) | FI66180C (cs) |
| GR (1) | GR68185B (cs) |
| HU (1) | HU180252B (cs) |
| IE (1) | IE49170B1 (cs) |
| IL (1) | IL57324A (cs) |
| MW (1) | MW1379A1 (cs) |
| NO (1) | NO791722L (cs) |
| NZ (1) | NZ190402A (cs) |
| PH (1) | PH14793A (cs) |
| PT (1) | PT69650A (cs) |
| ZA (1) | ZA792247B (cs) |
| ZM (1) | ZM4579A1 (cs) |
| ZW (1) | ZW9179A1 (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8629567D0 (en) * | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| AU7080298A (en) * | 1997-04-25 | 1998-11-24 | Takeda Chemical Industries Ltd. | Triazine derivatives, their production and agrochemical composition |
| US6335339B1 (en) | 1998-01-13 | 2002-01-01 | Scriptgen Pharmaceuticals, Inc. | Triazine antiviral compounds |
| JP2005532295A (ja) * | 2002-04-17 | 2005-10-27 | メディカル リサーチ カウンシル | 月経過多を治療するためのＦＰレセプターアンタゴニスト又はＰＧＦ２αアンタゴニスト |
| WO2005013947A2 (en) * | 2003-07-29 | 2005-02-17 | Universitätsklinikum Münster | Means and methods for treating a disease which is associated with an excess transport of hyaluronan across a lipid bilayer |
| US7199156B2 (en) * | 2003-10-10 | 2007-04-03 | Milos Chvapil | Composition and method to treat solid tumors |
| TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| CA2652773A1 (en) * | 2006-05-22 | 2007-12-06 | Combinatorx, Incorporated | Methods and compositions for the treatment of diseases or conditions associated with increased c-reactive protein, interleukin-6, or interferon-gamma levels |
| WO2009038708A1 (en) * | 2007-09-19 | 2009-03-26 | Combinatorx, Incorporated | Therapeutic regimens for the treatment of immunoinflammatory disorders |
| EP2231129A4 (en) * | 2007-12-17 | 2013-01-30 | Zalicus Inc | THERAPEUTIC REGIMES FOR THE TREATMENT OF IMMUNO-INFLAMMATORY DISORDERS |
| EP2399910B1 (en) * | 2009-02-13 | 2014-04-02 | Shionogi&Co., Ltd. | Triazine derivatives as p2x3 and/or p2x2/3 receptor antagonists and pharmaceutical composition containing them |
| EP2604260B1 (en) | 2010-08-10 | 2017-05-10 | Shionogi&Co., Ltd. | Novel heterocyclic derivatives and pharmaceutical composition containing same |
| JP5594706B2 (ja) * | 2010-08-10 | 2014-09-24 | 塩野義製薬株式会社 | トリアジン誘導体およびそれを含有する鎮痛作用を有する医薬組成物 |
| JP6124351B2 (ja) | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| EP4284869A4 (en) * | 2021-01-26 | 2024-12-25 | Council of Scientific and Industrial Research | Triazine-based self-assembling system |
| MX2023010673A (es) * | 2021-03-17 | 2023-09-22 | Hansoh Bio Llc | Cetonas heterociclicas que contienen nitrogeno, metodos de preparacion y usos medicinales de las mismas. |
| CN120574183B (zh) * | 2025-07-31 | 2025-11-21 | 潍坊鑫洋化工有限公司 | 一种溴代三嗪的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983116A (en) * | 1973-04-05 | 1976-09-28 | E. I. Du Pont De Nemours And Company | Herbicidal triazines |
| GB1543037A (en) * | 1975-02-05 | 1979-03-28 | Ici Ltd | Selective herbicidal triazine-diones |
| GB1464248A (en) | 1973-11-01 | 1977-02-09 | Ici Ltd | Substituted triazinediones their preparation and use as herbicides |
| US4082536A (en) * | 1973-11-01 | 1978-04-04 | Imperial Chemical Industries Limited | Heterocyclic compounds and their use as pesticides |
| US4035365A (en) * | 1973-11-01 | 1977-07-12 | Imperial Chemical Industries Limited | Triazinediones |
| GB1504304A (en) * | 1974-02-15 | 1978-03-15 | Ici Ltd | Process of combating fungal and bacterial infections of plants with triazine dione derivatives |
| GB1599518A (en) * | 1977-02-21 | 1981-10-07 | Ici Ltd | 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof |
-
1979
- 1979-05-02 DE DE7979300756T patent/DE2962124D1/de not_active Expired
- 1979-05-02 AT AT79300756T patent/ATE698T1/de not_active IP Right Cessation
- 1979-05-02 EP EP79300756A patent/EP0005911B1/en not_active Expired
- 1979-05-07 CA CA327,103A patent/CA1108138A/en not_active Expired
- 1979-05-07 US US06/036,508 patent/US4254122A/en not_active Expired - Lifetime
- 1979-05-09 NZ NZ190402A patent/NZ190402A/xx unknown
- 1979-05-09 ZA ZA792247A patent/ZA792247B/xx unknown
- 1979-05-10 AU AU46949/79A patent/AU529948B2/en not_active Ceased
- 1979-05-15 ZW ZW91/79A patent/ZW9179A1/xx unknown
- 1979-05-17 MW MW13/79A patent/MW1379A1/xx unknown
- 1979-05-17 IL IL57324A patent/IL57324A/xx unknown
- 1979-05-19 GR GR59133A patent/GR68185B/el unknown
- 1979-05-21 PH PH22523A patent/PH14793A/en unknown
- 1979-05-22 HU HU79IE875A patent/HU180252B/hu unknown
- 1979-05-22 PT PT69650A patent/PT69650A/pt unknown
- 1979-05-23 DK DK213179A patent/DK213179A/da not_active Application Discontinuation
- 1979-05-23 ZM ZM45/79A patent/ZM4579A1/xx unknown
- 1979-05-25 DD DD79213155A patent/DD143906A5/de unknown
- 1979-05-25 ES ES480932A patent/ES480932A1/es not_active Expired
- 1979-05-25 FI FI791670A patent/FI66180C/fi not_active IP Right Cessation
- 1979-05-25 CS CS793623A patent/CS213377B2/cs unknown
- 1979-05-25 NO NO791722A patent/NO791722L/no unknown
- 1979-05-25 JP JP6407279A patent/JPS54154779A/ja active Pending
- 1979-08-08 IE IE889/79A patent/IE49170B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0005911B1 (en) | 1982-02-17 |
| CA1108138A (en) | 1981-09-01 |
| GR68185B (cs) | 1981-11-09 |
| DK213179A (da) | 1979-11-27 |
| FI791670A7 (fi) | 1979-11-27 |
| AU529948B2 (en) | 1983-06-30 |
| DD143906A5 (de) | 1980-09-17 |
| US4254122A (en) | 1981-03-03 |
| DE2962124D1 (en) | 1982-03-25 |
| EP0005911A1 (en) | 1979-12-12 |
| CS213377B2 (en) | 1982-04-09 |
| IE790889L (en) | 1979-11-26 |
| FI66180B (fi) | 1984-05-31 |
| PT69650A (en) | 1979-06-01 |
| IL57324A0 (en) | 1979-09-30 |
| JPS54154779A (en) | 1979-12-06 |
| HU180252B (en) | 1983-02-28 |
| NO791722L (no) | 1979-11-27 |
| FI66180C (fi) | 1984-09-10 |
| ES480932A1 (es) | 1980-02-01 |
| IL57324A (en) | 1983-10-31 |
| IE49170B1 (en) | 1985-08-21 |
| ZW9179A1 (en) | 1981-01-21 |
| ZM4579A1 (en) | 1981-05-21 |
| MW1379A1 (en) | 1981-04-08 |
| AU4694979A (en) | 1979-11-29 |
| NZ190402A (en) | 1982-05-31 |
| ZA792247B (en) | 1980-05-28 |
| PH14793A (en) | 1981-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |