IL55664A - 1,3,4,14b-tetrahydro-2h,10h-pyrazino(1,2-a)pyrrolo-(2,1-c)(1,4)-benzodiazepines,their manufacture and pharmaceutical compositions containing them - Google Patents

1,3,4,14b-tetrahydro-2h,10h-pyrazino(1,2-a)pyrrolo-(2,1-c)(1,4)-benzodiazepines,their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL55664A
IL55664A IL55664A IL5566478A IL55664A IL 55664 A IL55664 A IL 55664A IL 55664 A IL55664 A IL 55664A IL 5566478 A IL5566478 A IL 5566478A IL 55664 A IL55664 A IL 55664A
Authority
IL
Israel
Prior art keywords
pyrazino
benzodiazepines
pyrrolo
tetrahydro
manufacture
Prior art date
Application number
IL55664A
Other languages
English (en)
Other versions
IL55664A0 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL55664A0 publication Critical patent/IL55664A0/xx
Publication of IL55664A publication Critical patent/IL55664A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL55664A 1977-10-05 1978-09-29 1,3,4,14b-tetrahydro-2h,10h-pyrazino(1,2-a)pyrrolo-(2,1-c)(1,4)-benzodiazepines,their manufacture and pharmaceutical compositions containing them IL55664A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83969677A 1977-10-05 1977-10-05

Publications (2)

Publication Number Publication Date
IL55664A0 IL55664A0 (en) 1978-12-17
IL55664A true IL55664A (en) 1982-02-28

Family

ID=25280422

Family Applications (1)

Application Number Title Priority Date Filing Date
IL55664A IL55664A (en) 1977-10-05 1978-09-29 1,3,4,14b-tetrahydro-2h,10h-pyrazino(1,2-a)pyrrolo-(2,1-c)(1,4)-benzodiazepines,their manufacture and pharmaceutical compositions containing them

Country Status (18)

Country Link
EP (1) EP0001585B1 (xx)
JP (1) JPS5461199A (xx)
AT (1) AT368157B (xx)
AU (1) AU521335B2 (xx)
CA (1) CA1113934A (xx)
DD (1) DD138774A5 (xx)
DE (1) DE2860861D1 (xx)
DK (1) DK441278A (xx)
ES (1) ES473900A1 (xx)
FI (1) FI63578C (xx)
HK (1) HK2185A (xx)
HU (1) HU179948B (xx)
IE (1) IE47390B1 (xx)
IL (1) IL55664A (xx)
NO (1) NO150159C (xx)
NZ (1) NZ188580A (xx)
SG (1) SG38684G (xx)
ZA (2) ZA784475B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737496A (en) * 1986-10-01 1988-04-12 Ciba-Geigy Corporation 1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists
PT95522B (pt) * 1989-10-05 1997-08-29 Sankyo Co Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem
EP0539164A1 (en) * 1991-10-23 1993-04-28 Sankyo Company Limited Nitrogen-containing tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
AUPP433398A0 (en) * 1998-06-25 1998-07-16 Australian National University, The Compounds and processes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3763183A (en) * 1972-07-10 1973-10-02 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US3985732A (en) * 1974-04-26 1976-10-12 American Cyanamid Company 1,2,3,11A-Tetrahydro-10-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5,11(10H)-diones
US3984562A (en) * 1975-02-24 1976-10-05 American Cyanamid Company Substituted benzodiazepines and method of use
US4017492A (en) * 1976-04-02 1977-04-12 The Upjohn Company As-triazinobenzodiazepin-1-ones
US4073784A (en) * 1977-03-09 1978-02-14 The Upjohn Company Certain as-triazino 4,3-a! 1,4!benzodiazepine-1,2-dione compounds

Also Published As

Publication number Publication date
JPS5461199A (en) 1979-05-17
AT368157B (de) 1982-09-27
NZ188580A (en) 1981-12-15
IE781985L (en) 1979-04-05
AU4040178A (en) 1980-04-17
HK2185A (en) 1985-01-18
ZA785599B (en) 1979-09-26
FI63578B (fi) 1983-03-31
FI63578C (fi) 1983-07-11
IE47390B1 (en) 1984-03-07
HU179948B (en) 1983-01-28
FI782994A (fi) 1979-04-06
IL55664A0 (en) 1978-12-17
NO150159B (no) 1984-05-21
NO783360L (no) 1979-04-06
EP0001585B1 (de) 1981-07-22
ES473900A1 (es) 1979-04-16
DK441278A (da) 1979-04-06
CA1113934A (en) 1981-12-08
DD138774A5 (de) 1979-11-21
ATA715178A (de) 1982-01-15
NO150159C (no) 1984-08-29
ZA784475B (en) 1979-07-25
AU521335B2 (en) 1982-03-25
DE2860861D1 (en) 1981-10-29
SG38684G (en) 1985-03-29
EP0001585A1 (de) 1979-05-02

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