IL47394A - ((imidazolyl or thiazolyl)alkyl(thio)alkyl) guanidine derivatives process for their preparation and pharmaceutical compositions containing them - Google Patents

((imidazolyl or thiazolyl)alkyl(thio)alkyl) guanidine derivatives process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL47394A
IL47394A IL47394A IL4739475A IL47394A IL 47394 A IL47394 A IL 47394A IL 47394 A IL47394 A IL 47394A IL 4739475 A IL4739475 A IL 4739475A IL 47394 A IL47394 A IL 47394A
Authority
IL
Israel
Prior art keywords
alkyl
thiazolyl
imidazolyl
thio
preparation
Prior art date
Application number
IL47394A
Other languages
English (en)
Other versions
IL47394A0 (en
Inventor
C Ganellin
G Durant
G Owen
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of IL47394A0 publication Critical patent/IL47394A0/xx
Publication of IL47394A publication Critical patent/IL47394A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL47394A 1974-06-28 1975-05-30 ((imidazolyl or thiazolyl)alkyl(thio)alkyl) guanidine derivatives process for their preparation and pharmaceutical compositions containing them IL47394A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28722/74A GB1497260A (en) 1974-06-28 1974-06-28 Guanidine derivatives

Publications (2)

Publication Number Publication Date
IL47394A0 IL47394A0 (en) 1975-07-28
IL47394A true IL47394A (en) 1980-01-31

Family

ID=10280055

Family Applications (1)

Application Number Title Priority Date Filing Date
IL47394A IL47394A (en) 1974-06-28 1975-05-30 ((imidazolyl or thiazolyl)alkyl(thio)alkyl) guanidine derivatives process for their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4034101A (sv)
JP (1) JPS5946221B2 (sv)
AU (1) AU503858B2 (sv)
BE (1) BE830272A (sv)
CA (1) CA1076579A (sv)
CH (1) CH615669A5 (sv)
DE (1) DE2528639A1 (sv)
DK (1) DK268975A (sv)
ES (1) ES438944A1 (sv)
FR (1) FR2276042A1 (sv)
GB (1) GB1497260A (sv)
IE (1) IE41625B1 (sv)
IL (1) IL47394A (sv)
LU (1) LU72835A1 (sv)
NL (1) NL7506951A (sv)
NO (1) NO143942C (sv)
PH (1) PH14275A (sv)
PL (1) PL98616B1 (sv)
SE (1) SE417961B (sv)
ZA (1) ZA753455B (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5014808U (sv) * 1973-06-06 1975-02-17
JPS55822B2 (sv) * 1973-07-09 1980-01-10
GB1493931A (en) * 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas
US4197305A (en) * 1974-02-07 1980-04-08 Smith Kline & French Laboratories Limited Thiazole, isothiazole, oxazole and isoxazole compounds
US4137319A (en) * 1974-02-07 1979-01-30 Smith Kline & French Laboratories Limited Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
US4170652A (en) * 1974-03-12 1979-10-09 Smith Kline & French Laboratories Limited Heterocyclic-methylthioalkyl-guanidines
GB1496787A (en) * 1974-03-12 1978-01-05 Smith Kline French Lab Heteroalkylthioalkyl amidine derivatives
JPS5912767Y2 (ja) * 1974-03-28 1984-04-17 アイワ カブシキガイシヤ 回転機器の作動切換装置
US4093729A (en) * 1974-06-28 1978-06-06 Smith Kline & French Laboratories Limited N-Oxy and N-amino guanidines
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4192879A (en) * 1975-05-21 1980-03-11 Smith Kline & French Laboratories Limited Imidazolyl alkylamino nitroethylene compounds
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
US4108859A (en) * 1977-06-06 1978-08-22 The Dow Chemical Company Microbicidal (pyridinylamino) alkyl guanidines
US4233302A (en) 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
EP0006679B1 (en) 1978-05-24 1982-07-21 Imperial Chemical Industries Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
CA1140925A (en) * 1978-10-16 1983-02-08 Derrick F. Jones Antisecretory branched chain heterocyclic derivatives, processes for their manufacture and pharmaceutical compositions containing them
JPS56124143A (en) * 1980-02-29 1981-09-29 Sanyo Electric Co Ltd Control mechanism of tape recorder
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
JPS6156012U (sv) * 1984-09-19 1986-04-15
JPS61228914A (ja) * 1985-04-04 1986-10-13 Sumitomo Heavy Ind Ltd 成形用金型
JPH0347862Y2 (sv) * 1985-12-14 1991-10-14
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines

Also Published As

Publication number Publication date
DK268975A (da) 1975-12-29
NO143942C (no) 1981-05-13
NO752330L (sv) 1975-12-30
ZA753455B (en) 1976-04-28
SE417961B (sv) 1981-04-27
NO143942B (no) 1981-02-02
GB1497260A (en) 1978-01-05
DE2528639A1 (de) 1976-01-15
IE41625L (en) 1975-12-28
PL98616B1 (pl) 1978-05-31
CA1076579A (en) 1980-04-29
IL47394A0 (en) 1975-07-28
SE7507364L (sv) 1975-12-29
CH615669A5 (sv) 1980-02-15
NL7506951A (nl) 1975-12-30
PH14275A (en) 1981-04-29
AU8230475A (en) 1976-12-23
LU72835A1 (sv) 1975-10-08
JPS5119766A (sv) 1976-02-17
US4034101A (en) 1977-07-05
IE41625B1 (en) 1980-02-13
FR2276042B1 (sv) 1980-04-25
FR2276042A1 (fr) 1976-01-23
BE830272A (fr) 1975-12-16
ES438944A1 (es) 1977-02-16
AU503858B2 (en) 1979-09-27
JPS5946221B2 (ja) 1984-11-10

Similar Documents

Publication Publication Date Title
IL47394A (en) ((imidazolyl or thiazolyl)alkyl(thio)alkyl) guanidine derivatives process for their preparation and pharmaceutical compositions containing them
IL44752A (en) 1-imidazolyl (pyridyl,thiazolyl or isoxazolyl) alkyl (thio) alkylamino ethylene derivatives,their preparation and pharmaceutical compositions containing them
IL49528A0 (en) Heterocyclic guanidine and thiourea derivatives and pharmaceutical compositions containing them
GB1518444A (en) N-phenyl-imidazolidine derivatives processes for preparing them and pharmaceutical compositions containing them
GB1556919A (en) Piperidylindole derivatives processes for preparing them and pharmaceutical compositions containing them
GB2001624B (en) Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them
IL50005A (en) Alkoxypyridyl derivatives of urea,thiourea,guanidine and 1,1-diamino-2-nitroethylene,their preparation and pharmaceutical compositions containing them
IL50869A0 (en) Novel imidazole derivatives their preparation and pharmaceutical compositions containing them
ZA79315B (en) Guanidine derivatives,processes for their production and pharmaceutical compositions containing them
IL48508A (en) Pharmaceutical compositions comprising piperidylindole derivatives
IL58777A0 (en) Aminothiazole derivatives of 3-cephem-4-carboxylic acid,their preparation and pharmaceutical compositions containing them
IL51530A (en) Imidazolyl (thiazolyl) methyl-thioalkyl amidinoformic (sulfinic) acid derivatives,process for their preparation and pharmalceutical compositions containing them
GB1543004A (en) 7-aminothiazolylacetamido-cephalosporanic acid derivatives processes for preparing them and pharmaceutical compositions containing them
IL50230A0 (en) Novel imidazole derivatives their preparation and pharmaceutical compositions containing them
IL47015A (en) Derivatives of phenthylamino-ketones and phenthylamino-dioxolanes,their preparation and pharmaceutical compositions containing them
IL51850A (en) Pharmaceutical compositions containing 3-phenyl-1-aminothyl thiourea isothiourea or guanidine derivatives some novelcompounds of this type and their preparation
ZA791053B (en) 1-oxo-1hpyrimido benzthiazole derivatives processes for thheir preparation and pharmaceutical compositions containinning these compounds
IL51955A0 (en) Novel thiazole derivatives their preparation and pharmaceutical compositions containing them
IL54603A (en) Imidazolylalkyl(alkylthioalkyl)thiourea and guanidine derivatives,process for their preparation and pharmaceutical compositions containing them
IL60468A (en) 4-sulfamoylphenyl-2-phenyl-imino-1,3-thiazole derivatives,process for their preparation and pharmaceutical compositions containing them
NZ179599A (en) Xanthine derivatives, and pharmaceutical compositions containing such
GB1545939A (en) Derivatives of imidazole processes for their preparation and pharmaceutical compositions containing them
IL50874A (en) S-(6-(n'-methylthioureido)alkyl)and s(5-(n'-cyano-n"-methylguanidino)alkyl)isothiourea derivatives,process for their preparation and pharmaceutical compositions containing them
GB1552460A (en) Diphenylacetamide derivatives processes for their preparation and pharmaceutical compositions containing them
IL57533A (en) 17alpha-acetylene derivatives of androst-4-ene,process for preparing them and pharmaceutical compositions containing them