IL46707A - 3-phenylbutane-1,3-diol and 3-phenyl-3-hydroxybutyric acid derivatives, processes for their preparation, and compositions containing them - Google Patents
3-phenylbutane-1,3-diol and 3-phenyl-3-hydroxybutyric acid derivatives, processes for their preparation, and compositions containing themInfo
- Publication number
- IL46707A IL46707A IL46707A IL4670775A IL46707A IL 46707 A IL46707 A IL 46707A IL 46707 A IL46707 A IL 46707A IL 4670775 A IL4670775 A IL 4670775A IL 46707 A IL46707 A IL 46707A
- Authority
- IL
- Israel
- Prior art keywords
- group
- compound
- final product
- desired final
- substituted
- Prior art date
Links
- ZCLPSJAOEAKMPO-UHFFFAOYSA-N 3-hydroxy-3-phenylbutanoic acid Chemical class OC(=O)CC(O)(C)C1=CC=CC=C1 ZCLPSJAOEAKMPO-UHFFFAOYSA-N 0.000 title 1
- BQNJVHGCZBNKBG-UHFFFAOYSA-N 3-phenylbutane-1,3-diol Chemical compound OCCC(O)(C)C1=CC=CC=C1 BQNJVHGCZBNKBG-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000012467 final product Substances 0.000 abstract 5
- -1 4-phenoxyphenyl Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- HQRWWHIETAKIMO-UHFFFAOYSA-N 1-phenylbutan-1-ol Chemical class CCCC(O)C1=CC=CC=C1 HQRWWHIETAKIMO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000012954 diazonium Substances 0.000 abstract 1
- 150000001989 diazonium salts Chemical class 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/03—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by addition of hydroxy groups to unsaturated carbon-to-carbon bonds, e.g. with the aid of H2O2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/095—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of organic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
- C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2409761A DE2409761A1 (de) | 1974-03-01 | 1974-03-01 | Hydroxybuttersaeure-derivate und verfahren zu ihrer herstellung |
| DE2428686A DE2428686A1 (de) | 1974-06-14 | 1974-06-14 | 3-p-biphenylyl-butandiol-(1,3) und verfahren zu seiner herstellung |
| DE2431951A DE2431951A1 (de) | 1974-07-03 | 1974-07-03 | Phenylbutandiolderivate und verfahren zu ihrer herstellung |
| DE2436012A DE2436012A1 (de) | 1974-07-26 | 1974-07-26 | 3-p-phenoxyphenyl-3-hydroxybuttersaeure-derivate und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL46707A0 IL46707A0 (en) | 1975-04-25 |
| IL46707A true IL46707A (en) | 1978-09-29 |
Family
ID=27431815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL46707A IL46707A (en) | 1974-03-01 | 1975-02-25 | 3-phenylbutane-1,3-diol and 3-phenyl-3-hydroxybutyric acid derivatives, processes for their preparation, and compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4049823A (cs) |
| JP (1) | JPS50121241A (cs) |
| AT (1) | AT342033B (cs) |
| BE (1) | BE826062A (cs) |
| CA (1) | CA1054626A (cs) |
| CH (1) | CH614920A5 (cs) |
| CS (1) | CS187460B2 (cs) |
| DD (1) | DD118076A5 (cs) |
| DK (1) | DK82575A (cs) |
| ES (1) | ES435153A1 (cs) |
| FR (1) | FR2262515B1 (cs) |
| GB (1) | GB1445320A (cs) |
| HU (1) | HU170471B (cs) |
| IL (1) | IL46707A (cs) |
| NL (1) | NL7502401A (cs) |
| SE (1) | SE7502152L (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188491A (en) * | 1975-04-04 | 1980-02-12 | The Boots Company Limited | Preparation of therapeutic compounds |
| US4196215A (en) * | 1975-06-19 | 1980-04-01 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Alkyne compounds and method of use |
| IL115995A0 (en) * | 1994-11-15 | 1996-01-31 | Bayer Ag | Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1040735A (en) * | 1964-07-23 | 1966-09-01 | British Drug Houses Ltd | 4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof |
-
1975
- 1975-02-05 CS CS75753A patent/CS187460B2/cs unknown
- 1975-02-24 GB GB768275A patent/GB1445320A/en not_active Expired
- 1975-02-25 US US05/552,959 patent/US4049823A/en not_active Expired - Lifetime
- 1975-02-25 FR FR7505769A patent/FR2262515B1/fr not_active Expired
- 1975-02-25 IL IL46707A patent/IL46707A/xx unknown
- 1975-02-26 SE SE7502152A patent/SE7502152L/xx unknown
- 1975-02-27 DD DD184467A patent/DD118076A5/xx unknown
- 1975-02-27 CA CA220906A patent/CA1054626A/en not_active Expired
- 1975-02-27 ES ES435153A patent/ES435153A1/es not_active Expired
- 1975-02-27 BE BE153812A patent/BE826062A/xx unknown
- 1975-02-27 HU HUME1841A patent/HU170471B/hu unknown
- 1975-02-27 JP JP50024936A patent/JPS50121241A/ja active Pending
- 1975-02-28 NL NL7502401A patent/NL7502401A/ not_active Application Discontinuation
- 1975-02-28 AT AT155975A patent/AT342033B/de not_active IP Right Cessation
- 1975-02-28 DK DK82575*#A patent/DK82575A/da unknown
- 1975-02-28 CH CH1283678A patent/CH614920A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE7502152L (cs) | 1975-09-02 |
| DK82575A (cs) | 1975-09-02 |
| DD118076A5 (cs) | 1976-02-12 |
| BE826062A (fr) | 1975-08-27 |
| AT342033B (de) | 1978-03-10 |
| CS187460B2 (en) | 1979-01-31 |
| ES435153A1 (es) | 1977-03-16 |
| CH614920A5 (cs) | 1979-12-28 |
| US4049823A (en) | 1977-09-20 |
| AU7860875A (en) | 1976-08-26 |
| FR2262515A1 (cs) | 1975-09-26 |
| HU170471B (cs) | 1977-06-28 |
| JPS50121241A (cs) | 1975-09-23 |
| ATA155975A (de) | 1977-07-15 |
| IL46707A0 (en) | 1975-04-25 |
| CA1054626A (en) | 1979-05-15 |
| FR2262515B1 (cs) | 1978-12-08 |
| GB1445320A (en) | 1976-08-11 |
| NL7502401A (nl) | 1975-09-03 |
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