IL45589A - Live influenza virus vaccines and preparation thereof - Google Patents
Live influenza virus vaccines and preparation thereofInfo
- Publication number
- IL45589A IL45589A IL45589A IL4558974A IL45589A IL 45589 A IL45589 A IL 45589A IL 45589 A IL45589 A IL 45589A IL 4558974 A IL4558974 A IL 4558974A IL 45589 A IL45589 A IL 45589A
- Authority
- IL
- Israel
- Prior art keywords
- strain
- serum
- influenza virus
- virus
- process according
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title claims description 33
- 229960005486 vaccine Drugs 0.000 title description 16
- 238000002360 preparation method Methods 0.000 title description 6
- 210000002966 serum Anatomy 0.000 claims description 50
- 241000700605 Viruses Species 0.000 claims description 34
- 239000003112 inhibitor Substances 0.000 claims description 26
- 235000013601 eggs Nutrition 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 238000010790 dilution Methods 0.000 claims description 20
- 239000012895 dilution Substances 0.000 claims description 20
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
- 230000002238 attenuated effect Effects 0.000 claims description 9
- 241000287828 Gallus gallus Species 0.000 claims description 8
- 241000700199 Cavia porcellus Species 0.000 claims description 7
- 206010022000 influenza Diseases 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 229940124873 Influenza virus vaccine Drugs 0.000 claims description 4
- 238000011534 incubation Methods 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000003306 harvesting Methods 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 241000282339 Mustela Species 0.000 description 7
- 238000011081 inoculation Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 239000012297 crystallization seed Substances 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 229960003971 influenza vaccine Drugs 0.000 description 4
- 239000001888 Peptone Substances 0.000 description 3
- 108010080698 Peptones Proteins 0.000 description 3
- 244000309464 bull Species 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000019319 peptone Nutrition 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000353621 Eilat virus Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 101100270435 Mus musculus Arhgef12 gene Proteins 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 206010062106 Respiratory tract infection viral Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000003067 hemagglutinative effect Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL52222A IL52222A (en) | 1974-09-04 | 1977-06-01 | Live influenza virus vaccine and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/401,335 US3953592A (en) | 1973-09-27 | 1973-09-27 | Live influenza virus vaccines and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL45589A0 IL45589A0 (en) | 1974-11-29 |
| IL45589A true IL45589A (en) | 1977-05-31 |
Family
ID=23587327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL45589A IL45589A (en) | 1973-09-27 | 1974-09-04 | Live influenza virus vaccines and preparation thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3953592A (xx) |
| JP (1) | JPS5058223A (xx) |
| AT (1) | AT331978B (xx) |
| BE (1) | BE819865A (xx) |
| CA (1) | CA1030450A (xx) |
| CH (1) | CH595447A5 (xx) |
| CS (1) | CS203080B2 (xx) |
| DD (1) | DD114966A5 (xx) |
| DE (1) | DE2445819A1 (xx) |
| DK (1) | DK508274A (xx) |
| ES (1) | ES430415A1 (xx) |
| FI (1) | FI278774A (xx) |
| FR (1) | FR2245376B1 (xx) |
| GB (1) | GB1461188A (xx) |
| HU (1) | HU169383B (xx) |
| IE (1) | IE40180B1 (xx) |
| IL (1) | IL45589A (xx) |
| LU (1) | LU70998A1 (xx) |
| NL (1) | NL7411746A (xx) |
| NO (1) | NO743433L (xx) |
| SE (1) | SE429405B (xx) |
| ZA (1) | ZA745571B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6042209B2 (ja) * | 1974-05-31 | 1985-09-20 | 北里研究所（社団法人） | インフルエンザウイルスの新鮮分離株を発育鶏卵へ短期間で順化させる方法 |
| US4318903A (en) * | 1978-07-12 | 1982-03-09 | Smithkline-Rit | Live influenza virus vaccine and the preparation thereof |
| US4278662A (en) * | 1979-10-16 | 1981-07-14 | Smith Kline - Rit | Attenuated influenza type A virus vaccine |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| NZ224422A (en) * | 1987-05-05 | 1990-11-27 | Molecular Eng Ass | Composition adapted for intranasal immunisation against viral infection comprising a glycoprotein complexed with a lipid |
| US6398774B1 (en) | 1999-09-29 | 2002-06-04 | Heska Corporation | Intranasal delivery system |
| US7678087B2 (en) * | 1999-09-29 | 2010-03-16 | Heska Corporation | Equine intranasal delivery system |
| CA2756206A1 (en) | 2009-03-27 | 2010-09-30 | Academia Sinica | Methods and compositions for immunization against virus |
| TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
-
1973
- 1973-09-27 US US05/401,335 patent/US3953592A/en not_active Expired - Lifetime
-
1974
- 1974-08-28 CH CH1173374A patent/CH595447A5/xx not_active IP Right Cessation
- 1974-08-29 CA CA208,125A patent/CA1030450A/en not_active Expired
- 1974-08-30 ZA ZA00745571A patent/ZA745571B/xx unknown
- 1974-09-04 IL IL45589A patent/IL45589A/en unknown
- 1974-09-04 NL NL7411746A patent/NL7411746A/xx not_active Application Discontinuation
- 1974-09-13 FR FR7431029A patent/FR2245376B1/fr not_active Expired
- 1974-09-13 BE BE148474A patent/BE819865A/xx not_active IP Right Cessation
- 1974-09-21 JP JP49109440A patent/JPS5058223A/ja active Pending
- 1974-09-24 NO NO743433A patent/NO743433L/no unknown
- 1974-09-24 CS CS746552A patent/CS203080B2/cs unknown
- 1974-09-25 FI FI2787/74A patent/FI278774A/fi unknown
- 1974-09-25 LU LU70998A patent/LU70998A1/xx unknown
- 1974-09-25 DE DE19742445819 patent/DE2445819A1/de not_active Ceased
- 1974-09-26 HU HURE565A patent/HU169383B/hu unknown
- 1974-09-26 IE IE1994/74A patent/IE40180B1/xx unknown
- 1974-09-26 DD DD181344A patent/DD114966A5/xx unknown
- 1974-09-26 SE SE7412113A patent/SE429405B/sv unknown
- 1974-09-26 AT AT776074A patent/AT331978B/de active
- 1974-09-26 ES ES430415A patent/ES430415A1/es not_active Expired
- 1974-09-26 GB GB4184974A patent/GB1461188A/en not_active Expired
- 1974-09-26 DK DK508274A patent/DK508274A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5058223A (xx) | 1975-05-21 |
| US3953592A (en) | 1976-04-27 |
| ZA745571B (en) | 1975-09-24 |
| CS203080B2 (en) | 1981-02-27 |
| GB1461188A (en) | 1977-01-13 |
| CH595447A5 (xx) | 1978-02-15 |
| SE429405B (sv) | 1983-09-05 |
| IE40180B1 (en) | 1979-03-28 |
| IE40180L (en) | 1975-03-27 |
| CA1030450A (en) | 1978-05-02 |
| FI278774A (xx) | 1975-03-28 |
| HU169383B (xx) | 1976-11-28 |
| FR2245376A1 (xx) | 1975-04-25 |
| DE2445819A1 (de) | 1975-04-10 |
| DK508274A (xx) | 1975-06-02 |
| NL7411746A (nl) | 1975-04-02 |
| ATA776074A (de) | 1975-12-15 |
| AU7330674A (en) | 1976-03-18 |
| NO743433L (xx) | 1975-04-28 |
| BE819865A (fr) | 1975-03-13 |
| DD114966A5 (xx) | 1975-09-05 |
| FR2245376B1 (xx) | 1978-07-28 |
| IL45589A0 (en) | 1974-11-29 |
| AT331978B (de) | 1976-09-10 |
| LU70998A1 (xx) | 1975-03-06 |
| SE7412113L (xx) | 1975-04-01 |
| ES430415A1 (es) | 1977-02-01 |
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