IL45006A - Imidazolyl, pyridyl and thiazolyl ureas, thioureas and guanidines and process for their preparation - Google Patents
Imidazolyl, pyridyl and thiazolyl ureas, thioureas and guanidines and process for their preparationInfo
- Publication number
- IL45006A IL45006A IL45006A IL4500674A IL45006A IL 45006 A IL45006 A IL 45006A IL 45006 A IL45006 A IL 45006A IL 4500674 A IL4500674 A IL 4500674A IL 45006 A IL45006 A IL 45006A
- Authority
- IL
- Israel
- Prior art keywords
- thioureas
- guanidines
- imidazolyl
- pyridyl
- preparation
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title 1
- 150000002357 guanidines Chemical class 0.000 title 1
- 125000002883 imidazolyl group Chemical group 0.000 title 1
- 125000004076 pyridyl group Chemical group 0.000 title 1
- -1 thiazolyl ureas Chemical class 0.000 title 1
- 150000003585 thioureas Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3342873A GB1431589A (en) | 1973-07-13 | 1973-07-13 | Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL45006A0 IL45006A0 (en) | 1974-09-10 |
| IL45006A true IL45006A (en) | 1978-07-31 |
Family
ID=10352834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL45006A IL45006A (en) | 1973-07-13 | 1974-06-11 | Imidazolyl, pyridyl and thiazolyl ureas, thioureas and guanidines and process for their preparation |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4499101A (sv) |
| JP (1) | JPS5830314B2 (sv) |
| AR (3) | AR204928A1 (sv) |
| AT (1) | AT346855B (sv) |
| BE (1) | BE816850A (sv) |
| BG (1) | BG25792A3 (sv) |
| CA (1) | CA1049524A (sv) |
| CH (1) | CH601252A5 (sv) |
| CS (1) | CS199255B2 (sv) |
| DD (1) | DD112449A5 (sv) |
| DE (1) | DE2433625A1 (sv) |
| DK (1) | DK334674A (sv) |
| EG (1) | EG11259A (sv) |
| ES (3) | ES428246A1 (sv) |
| FI (1) | FI213274A (sv) |
| FR (1) | FR2274298A1 (sv) |
| GB (1) | GB1431589A (sv) |
| HU (1) | HU169394B (sv) |
| IE (1) | IE39607B1 (sv) |
| IL (1) | IL45006A (sv) |
| IN (1) | IN140943B (sv) |
| LU (1) | LU70507A1 (sv) |
| MW (1) | MW2674A1 (sv) |
| NL (1) | NL7408942A (sv) |
| NO (1) | NO143063C (sv) |
| OA (1) | OA04814A (sv) |
| PH (1) | PH11618A (sv) |
| PL (3) | PL98609B1 (sv) |
| SE (1) | SE416202B (sv) |
| SU (3) | SU559647A3 (sv) |
| ZM (1) | ZM10374A1 (sv) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215125A (en) | 1973-07-13 | 1980-07-29 | Smith Kline & French Laboratories Limited | Pyridyl ureas, thioureas and guanidines |
| US4070472A (en) * | 1974-02-07 | 1978-01-24 | Smith Kline & French Laboratories Limited | Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine |
| US4151289A (en) | 1975-01-22 | 1979-04-24 | Smith Kline & French Laboratories Limited | Nitromethylene amidino derivatives containing imidazole groups |
| GB1542840A (en) * | 1975-02-03 | 1979-03-28 | Smith Kline French Lab | Heterocyclic dithiocarbamates and isothioureas |
| US4120966A (en) | 1975-02-03 | 1978-10-17 | Smith Kline & French Laboratories Limited | Heterocyclic-methylthioethyl-dithiocarbamates and isothioureas |
| IL49528A (en) | 1975-05-21 | 1980-11-30 | Smith Kline French Lab | Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them |
| IE47044B1 (en) | 1977-04-20 | 1983-12-14 | Ici Ltd | Guanidine derivatives |
| US4165378A (en) | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| US4233302A (en) | 1977-12-23 | 1980-11-11 | Glaxo Group Limited | Amine derivatives and pharmaceutical compositions containing them |
| US4309435A (en) | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
| JPS5610175A (en) * | 1979-07-06 | 1981-02-02 | Fujisawa Pharmaceut Co Ltd | Preparation of imidazole derivative |
| JPS5775975A (en) * | 1980-08-27 | 1982-05-12 | Glaxo Group Ltd | Heterocyclic derivative, manufacture and medicinal composition containing same |
| DE3366369D1 (en) * | 1982-03-17 | 1986-10-30 | Smith Kline French Lab | Pyridine derivatives |
| EP0199845B1 (de) * | 1985-04-02 | 1990-08-01 | HEUMANN PHARMA GMBH & CO | Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3512084A1 (de) * | 1985-04-02 | 1986-10-09 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | Guanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3631334A1 (de) * | 1986-09-15 | 1988-03-17 | Heumann Pharma Gmbh & Co | Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| NL9100365A (nl) * | 1991-02-27 | 1992-09-16 | Seed Capital Investments | Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor. |
| ES2108107T3 (es) * | 1991-02-27 | 1997-12-16 | Seed Capital Investments | Derivados de imidazol que tienen actividad antagonista en el receptor h3 de histamina. |
| DK1032556T3 (da) * | 1997-10-21 | 2008-03-25 | Wyeth Corp | Farmaceutisk aktive forbindelser og anvendelsesfremgangsmåder |
| US7041702B1 (en) | 1997-10-21 | 2006-05-09 | Scion Pharmaceuticals, Inc. | Pharmaceutically active compounds and methods of use |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL292485A (sv) * | 1962-05-09 | |||
| CH484918A (de) * | 1965-10-28 | 1970-01-31 | Ciba Geigy | Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen |
| US3770755A (en) * | 1967-09-26 | 1973-11-06 | Ici Ltd | 4-(4-bromophenyl)-2-(2-hydroxysopropyl) thiazole |
| BE758146A (fr) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | Derives de l'amidine |
| US3868457A (en) * | 1969-10-29 | 1975-02-25 | Smith Kline French Lab | Method of inhibiting histamine activity with guanidine compounds |
| US3749728A (en) * | 1972-02-15 | 1973-07-31 | Smith Kline French Lab | N-cycloalkyl and n-cycloalkane-alkylthioamides |
| US3821229A (en) * | 1972-12-07 | 1974-06-28 | American Cyanamid Co | Diquaternary salts of di-4-pyridyl ketone |
| US4013659A (en) * | 1973-07-13 | 1977-03-22 | Smith Kline & French Laboratories Limited | Certain n,n'-disubstituted guanidine compounds and their use |
| US4154838A (en) * | 1975-07-31 | 1979-05-15 | Smith Kline & French Laboratories Limited | Alkoxy pyridine |
-
1973
- 1973-07-13 GB GB3342873A patent/GB1431589A/en not_active Expired
-
1974
- 1974-01-01 AR AR254698A patent/AR204928A1/es active
- 1974-06-11 IL IL45006A patent/IL45006A/xx unknown
- 1974-06-19 MW MW26/74*UA patent/MW2674A1/xx unknown
- 1974-06-21 DK DK334674A patent/DK334674A/da not_active Application Discontinuation
- 1974-06-21 PH PH15964A patent/PH11618A/en unknown
- 1974-06-25 BE BE145878A patent/BE816850A/xx not_active IP Right Cessation
- 1974-06-25 ZM ZM103/74A patent/ZM10374A1/xx unknown
- 1974-06-28 FR FR7422670A patent/FR2274298A1/fr active Granted
- 1974-07-02 NL NL7408942A patent/NL7408942A/xx not_active Application Discontinuation
- 1974-07-04 AT AT552674A patent/AT346855B/de not_active IP Right Cessation
- 1974-07-05 JP JP49077751A patent/JPS5830314B2/ja not_active Expired
- 1974-07-06 EG EG260/74A patent/EG11259A/xx active
- 1974-07-09 CH CH943074A patent/CH601252A5/xx not_active IP Right Cessation
- 1974-07-11 FI FI2132/74A patent/FI213274A/fi unknown
- 1974-07-11 CA CA204,550A patent/CA1049524A/en not_active Expired
- 1974-07-11 LU LU70507A patent/LU70507A1/xx unknown
- 1974-07-12 DD DD179888A patent/DD112449A5/xx unknown
- 1974-07-12 PL PL1974183273A patent/PL98609B1/pl unknown
- 1974-07-12 CS CS744991A patent/CS199255B2/cs unknown
- 1974-07-12 SE SE7409188A patent/SE416202B/sv not_active IP Right Cessation
- 1974-07-12 PL PL1974172671A patent/PL96460B1/pl unknown
- 1974-07-12 HU HUSI1421A patent/HU169394B/hu unknown
- 1974-07-12 NO NO742563A patent/NO143063C/no unknown
- 1974-07-12 SU SU2043788A patent/SU559647A3/ru active
- 1974-07-12 OA OA55247A patent/OA04814A/xx unknown
- 1974-07-12 PL PL1974183272A patent/PL98705B1/pl unknown
- 1974-07-12 DE DE2433625A patent/DE2433625A1/de not_active Withdrawn
- 1974-07-12 IE IE1480/74A patent/IE39607B1/xx unknown
- 1974-07-13 ES ES428246A patent/ES428246A1/es not_active Expired
- 1974-07-13 BG BG027239A patent/BG25792A3/xx unknown
- 1974-07-18 IN IN1600/CAL/1974A patent/IN140943B/en unknown
-
1975
- 1975-05-13 AR AR258761A patent/AR202617A1/es active
- 1975-05-13 AR AR258762A patent/AR202618A1/es active
- 1975-05-19 ES ES437770A patent/ES437770A1/es not_active Expired
- 1975-05-19 ES ES437769A patent/ES437769A1/es not_active Expired
- 1975-09-04 SU SU7502168215A patent/SU571193A3/ru active
- 1975-09-05 SU SU7502169007A patent/SU567405A3/ru active
-
1983
- 1983-02-04 US US06/463,768 patent/US4499101A/en not_active Expired - Lifetime
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