IL43865A - 4-phenyl-1,6,7,8-tetrahydro-1,3-dialkyl-pyrazolo(3,4-e)(1,4)diazepines and their production - Google Patents
4-phenyl-1,6,7,8-tetrahydro-1,3-dialkyl-pyrazolo(3,4-e)(1,4)diazepines and their productionInfo
- Publication number
- IL43865A IL43865A IL43865A IL4386573A IL43865A IL 43865 A IL43865 A IL 43865A IL 43865 A IL43865 A IL 43865A IL 4386573 A IL4386573 A IL 4386573A IL 43865 A IL43865 A IL 43865A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- tetrahydro
- methyl
- compound
- compounds
- Prior art date
Links
- 150000004908 diazepines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 4
- XYEVREOOMFVLLS-UHFFFAOYSA-N pyrazolo[4,3-c]diazepine Chemical class C1=CC=NN=C2C=NN=C21 XYEVREOOMFVLLS-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000000935 antidepressant agent Substances 0.000 claims abstract 2
- 229940005513 antidepressants Drugs 0.000 claims abstract 2
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- -1 chloro, bromo, fluoro, methyl Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- POXWDTQUDZUOGP-UHFFFAOYSA-N 1h-1,4-diazepine Chemical compound N1C=CC=NC=C1 POXWDTQUDZUOGP-UHFFFAOYSA-N 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 101100536354 Drosophila melanogaster tant gene Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001430 anti-depressive effect Effects 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- HFGQSURQDZNRIJ-UHFFFAOYSA-N chembl174832 Chemical compound C1=2C(C)=NN(C)C=2NCCN=C1C1=CC=CC(Br)=C1 HFGQSURQDZNRIJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 239000012954 diazonium Substances 0.000 claims 1
- 150000001989 diazonium salts Chemical class 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 1
- 238000006396 nitration reaction Methods 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- BVTVORSLKKSZEI-UHFFFAOYSA-N 1,2,3,3a,4,5-hexahydropyrazolo[4,3-c]diazepine Chemical compound N1NCC2C1=CC=CNN2 BVTVORSLKKSZEI-UHFFFAOYSA-N 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00315631A US3823157A (en) | 1972-12-15 | 1972-12-15 | Pyrazolodiazepine compounds and methods for their production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43865A0 IL43865A0 (en) | 1974-03-14 |
| IL43865A true IL43865A (en) | 1976-11-30 |
Family
ID=23225332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43865A IL43865A (en) | 1972-12-15 | 1973-12-20 | 4-phenyl-1,6,7,8-tetrahydro-1,3-dialkyl-pyrazolo(3,4-e)(1,4)diazepines and their production |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3823157A (is") |
| JP (1) | JPS5732072B2 (is") |
| AR (2) | AR200295A1 (is") |
| AT (1) | AT338794B (is") |
| AU (1) | AU472275B2 (is") |
| BE (1) | BE808599A (is") |
| CA (1) | CA1023356A (is") |
| CH (2) | CH590284A5 (is") |
| DE (1) | DE2362034A1 (is") |
| DK (1) | DK138020B (is") |
| ES (2) | ES421427A1 (is") |
| FI (1) | FI54803C (is") |
| FR (1) | FR2210403B1 (is") |
| GB (1) | GB1399230A (is") |
| HU (1) | HU166758B (is") |
| IE (1) | IE38641B1 (is") |
| IL (1) | IL43865A (is") |
| NL (1) | NL165743C (is") |
| NO (1) | NO140670C (is") |
| PH (1) | PH12257A (is") |
| SE (2) | SE410604B (is") |
| ZA (1) | ZA737696B (is") |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2290213A1 (fr) * | 1974-11-06 | 1976-06-04 | Parke Davis & Co | Nouveaux derives de diazepine et procedes pour leur production |
| DE2609486A1 (de) * | 1975-08-07 | 1977-05-12 | Hoffmann La Roche | Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung |
| US4075408A (en) * | 1975-09-08 | 1978-02-21 | Parke, Davis & Company | Imidazopyrazolodiazepine compounds |
| US4349476A (en) * | 1978-05-15 | 1982-09-14 | Hoffmann-La Roche Inc. | Process for producing imidazodiazepines |
| US4349477A (en) * | 1978-05-15 | 1982-09-14 | Hoffmann-La Roche Inc. | Process for producing imidazodiazepines |
| US4349475A (en) * | 1978-05-15 | 1982-09-14 | Hoffmann-La Roche Inc. | Process for producing imidazodiazepines |
| US4376075A (en) * | 1978-05-15 | 1983-03-08 | Hoffmann-La Roche Inc. | Process for producing imidazodiazepines |
| US4377523A (en) * | 1978-05-15 | 1983-03-22 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| JPS5961073U (ja) * | 1982-10-18 | 1984-04-21 | 株式会社タカラ | 盤ゲ−ム具 |
| JPH0394280U (is") * | 1990-01-12 | 1991-09-26 | ||
| RU2186772C2 (ru) * | 1999-11-11 | 2002-08-10 | Иркутский институт химии СО РАН | Производные 1-метил-5-хлорпиразола и способ их получения |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558605A (en) * | 1969-05-14 | 1971-01-26 | Parke Davis & Co | Pyrazolo(3,4-e)(1,4)diazepin-7-(1h)-one compounds |
-
1972
- 1972-12-15 US US00315631A patent/US3823157A/en not_active Expired - Lifetime
-
1973
- 1973-10-01 ZA ZA00737696A patent/ZA737696B/xx unknown
- 1973-12-10 PH PH15310A patent/PH12257A/en unknown
- 1973-12-13 BE BE138836A patent/BE808599A/xx unknown
- 1973-12-13 HU HUPA1180A patent/HU166758B/hu unknown
- 1973-12-13 CH CH1747173A patent/CH590284A5/xx not_active IP Right Cessation
- 1973-12-13 GB GB5792673A patent/GB1399230A/en not_active Expired
- 1973-12-13 NO NO4758/73A patent/NO140670C/no unknown
- 1973-12-13 NL NL7317113.A patent/NL165743C/xx not_active IP Right Cessation
- 1973-12-13 DE DE2362034A patent/DE2362034A1/de not_active Withdrawn
- 1973-12-13 AR AR251494A patent/AR200295A1/es active
- 1973-12-13 SE SE7316843A patent/SE410604B/xx unknown
- 1973-12-13 CH CH1391376A patent/CH591489A5/xx not_active IP Right Cessation
- 1973-12-13 FR FR7344548A patent/FR2210403B1/fr not_active Expired
- 1973-12-13 ES ES421427A patent/ES421427A1/es not_active Expired
- 1973-12-13 FI FI3833/73A patent/FI54803C/fi active
- 1973-12-13 AT AT1043473A patent/AT338794B/de not_active IP Right Cessation
- 1973-12-13 CA CA188,152A patent/CA1023356A/en not_active Expired
- 1973-12-13 AU AU63584/73A patent/AU472275B2/en not_active Expired
- 1973-12-13 JP JP13825273A patent/JPS5732072B2/ja not_active Expired
- 1973-12-13 DK DK676673AA patent/DK138020B/da unknown
- 1973-12-13 IE IE2260/73A patent/IE38641B1/xx unknown
- 1973-12-20 IL IL43865A patent/IL43865A/en unknown
-
1974
- 1974-01-01 AR AR256062A patent/AR204106A1/es active
- 1974-10-15 ES ES431015A patent/ES431015A1/es not_active Expired
-
1976
- 1976-10-08 SE SE7611202A patent/SE410605B/xx unknown
Also Published As
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