IL43751A - Des-lys29-ala30-insulins and their preparation - Google Patents
Des-lys29-ala30-insulins and their preparationInfo
- Publication number
- IL43751A IL43751A IL43751A IL4375173A IL43751A IL 43751 A IL43751 A IL 43751A IL 43751 A IL43751 A IL 43751A IL 4375173 A IL4375173 A IL 4375173A IL 43751 A IL43751 A IL 43751A
- Authority
- IL
- Israel
- Prior art keywords
- insulin
- des
- lys
- enzyme
- porcine
- Prior art date
Links
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- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940066758 endopeptidases Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- -1 oligopeptides Chemical compound 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5974272 | 1972-12-28 | ||
| GB438773*[A GB1426061A (en) | 1972-12-28 | 1973-01-29 | Polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43751A0 IL43751A0 (en) | 1974-03-14 |
| IL43751A true IL43751A (en) | 1977-01-31 |
Family
ID=26239087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43751A IL43751A (en) | 1972-12-28 | 1973-12-04 | Des-lys29-ala30-insulins and their preparation |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3903069A (ar) |
| JP (1) | JPS5726760B2 (ar) |
| AT (1) | AT348152B (ar) |
| AU (1) | AU474971B2 (ar) |
| CA (1) | CA1009974A (ar) |
| CH (1) | CH599927A5 (ar) |
| DD (1) | DD110490A5 (ar) |
| DE (1) | DE2364883C2 (ar) |
| ES (1) | ES421864A1 (ar) |
| FR (1) | FR2212136B1 (ar) |
| GB (1) | GB1426061A (ar) |
| HU (1) | HU170437B (ar) |
| IE (1) | IE38539B1 (ar) |
| IL (1) | IL43751A (ar) |
| LU (1) | LU69075A1 (ar) |
| NL (1) | NL7317159A (ar) |
| PL (1) | PL91158B1 (ar) |
| SE (1) | SE404600B (ar) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55138391A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
| NO153061C (no) * | 1979-04-13 | 1986-01-08 | Shionogi & Co | Fremgangsmaate for fremstilling av et b30-threonininsulin |
| WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
| DE3209184A1 (de) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen |
| US6673347B1 (en) | 1986-04-30 | 2004-01-06 | Gryphon Therapeutics | Polypeptide and protein derivatives and process for their preparation |
| GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| AU641631B2 (en) * | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH471220A (de) * | 1964-05-09 | 1969-04-15 | Roehm & Haas Gmbh | Verfahren zur Herstellung einer L-Leucinamid, Hypertensin und Oxytocin spaltenden Aminopeptidase |
-
1973
- 1973-01-29 GB GB438773*[A patent/GB1426061A/en not_active Expired
- 1973-11-22 IE IE2122/73A patent/IE38539B1/xx unknown
- 1973-11-23 CA CA186,556A patent/CA1009974A/en not_active Expired
- 1973-11-28 AU AU62979/73A patent/AU474971B2/en not_active Expired
- 1973-11-30 US US420573A patent/US3903069A/en not_active Expired - Lifetime
- 1973-12-04 IL IL43751A patent/IL43751A/en unknown
- 1973-12-14 NL NL7317159A patent/NL7317159A/xx unknown
- 1973-12-14 CH CH1759373A patent/CH599927A5/xx not_active IP Right Cessation
- 1973-12-15 PL PL1973167350A patent/PL91158B1/pl unknown
- 1973-12-20 SE SE7317256A patent/SE404600B/xx unknown
- 1973-12-21 DD DD175618A patent/DD110490A5/xx unknown
- 1973-12-26 JP JP744631A patent/JPS5726760B2/ja not_active Expired
- 1973-12-27 LU LU69075A patent/LU69075A1/xx unknown
- 1973-12-27 AT AT1084473A patent/AT348152B/de not_active IP Right Cessation
- 1973-12-27 FR FR7346550A patent/FR2212136B1/fr not_active Expired
- 1973-12-28 HU HUIE605A patent/HU170437B/hu unknown
- 1973-12-28 ES ES421864A patent/ES421864A1/es not_active Expired
- 1973-12-28 DE DE2364883A patent/DE2364883C2/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH599927A5 (ar) | 1978-06-15 |
| GB1426061A (en) | 1976-02-25 |
| DD110490A5 (ar) | 1974-12-20 |
| DE2364883C2 (de) | 1984-07-19 |
| FR2212136A1 (ar) | 1974-07-26 |
| DE2364883A1 (de) | 1974-07-04 |
| ES421864A1 (es) | 1976-08-01 |
| AU6297973A (en) | 1975-05-29 |
| PL91158B1 (ar) | 1977-02-28 |
| LU69075A1 (ar) | 1974-03-07 |
| AT348152B (de) | 1979-02-12 |
| IL43751A0 (en) | 1974-03-14 |
| ATA1084473A (de) | 1978-06-15 |
| JPS5726760B2 (ar) | 1982-06-07 |
| NL7317159A (ar) | 1974-07-02 |
| US3903069A (en) | 1975-09-02 |
| HU170437B (ar) | 1977-06-28 |
| SE404600B (sv) | 1978-10-16 |
| IE38539B1 (en) | 1978-04-12 |
| IE38539L (en) | 1974-06-28 |
| JPS4994698A (ar) | 1974-09-09 |
| CA1009974A (en) | 1977-05-10 |
| AU474971B2 (en) | 1976-08-05 |
| FR2212136B1 (ar) | 1978-01-06 |
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